The contribution of hypothalamic neuropeptide Y to age-dependent body weight changes [0.03%]
下丘脑神经肽Y对年龄依赖性体重变化的贡献
Fanni Pólai,Blanka Kárász,Márta Balaskó et al.
Fanni Pólai et al.
Middle-aged obesity and age-related anorexia leading to sarcopenia present a major public health burden. Similar age-associated patterns are observed across mammalian species, suggesting the involvement of conserved regulatory mechanisms. A...
TREM1 inhibition via LP17 alleviates secondary spinal cord injury by activating AMPKα-PINK1-parkin-dependent microglial mitophagy [0.03%]
通过LP17抑制TREM1激活AMPKα-PINK1-parkin依赖性的小胶质细胞线粒体自噬缓解继发性脊髓损伤
Bin Xia,Yuanfang Sun,Jin Liu et al.
Bin Xia et al.
Spinal cord injury (SCI) is characterized by primary mechanical trauma and subsequent secondary pathogenic cascades, with chronic neuroinflammation impeding neurological functional recovery. Microglial activation, mitochondrial dysfunction,...
Edina Szabo,Dorottya Molitor,Balazs Meresz et al.
Edina Szabo et al.
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a highly conserved neuropeptide with well-established neuroprotective actions in the central and peripheral nervous system. Owing to the developmental and functional relationship...
J U Silva,I Brito
J U Silva
Oxytocin plays an important and well-known role in promoting social interaction in maternal, sexual and interpersonal behaviors. In addition, it has been increasingly linked to the modulation of pain, fear and cognitive processes such as at...
Central neuropeptide Y differentially regulates body temperature between heat-exposed and non-heat-exposed chicks [0.03%]
中央神经肽Y调节热暴露与非热暴露鸡体核温度差异性作用
Maria Chatziioannidi,Haruka Nishimura,Mohamed Z Elhussiny et al.
Maria Chatziioannidi et al.
Heat stress due to exposure to high environmental temperatures influences thermoregulation and metabolic balance in poultry, and central neuropeptidergic pathways play a critical role in these responses. Central administration of neuropepti...
The influence of galanin receptor agonist during the seasonal recrudescence and nonbreeding phases of the ovarian cycle in the gekkonid lizard Hemidactylus frenatus [0.03%]
蛙眼守宫半指壁蜥卵巢周期季节性复发期和非繁殖期胰高血糖素样肽1受体激动剂的影响研究
Ananya Ganeyan,C B Ganesh
Ananya Ganeyan
Galanin (GAL), a neuropeptide produced in both the central and peripheral nervous systems, is implicated in various physiological processes, including reproduction in vertebrates. Yet, the role of GAL is not understood in reptilian reproduc...
Kisspeptin-10 attenuates pulmonary arterial hypertension via restoration of mitochondrial function in pulmonary artery smooth muscle cells [0.03%]
亲吻肽-10通过恢复肺动脉平滑肌细胞的线粒体功能来缓解肺动脉高压
Sijia Huang,Zixuan Chen,Wanwei Gong et al.
Sijia Huang et al.
Mitochondrial dysfunction and dysregulated mitophagy in pulmonary artery smooth muscle cells (PASMCs) critically drive pulmonary arterial hypertension (PAH). Here we show that Kisspeptin-10, acting via its receptor GPR54, markedly attenuate...
Microglial activation in diabetic neuropathic pain: Molecular trigger mechanisms, neuroimmune crosstalk, and emerging therapeutic targets [0.03%]
糖尿病性神经病理性疼痛中的小胶质细胞活化：分子触发机制、神经免疫信号转导和新兴治疗靶点
Jilin Wang,Huamao Zhou
Jilin Wang
Diabetic neuropathic pain (DNP) is a common and debilitating complication of diabetes that profoundly reduces patient quality of life. Despite extensive research, current treatments remain largely symptomatic, with limited efficacy and sign...
Systemic irisin treatment modulates cognitive function through VEGF-associated hippocampal vascular signaling in chronic cerebral hypoperfusion [0.03%]
系统性irisin治疗通过慢性脑低灌注下VEGF相关海马血管信号传导调节认知功能
Aslı Karakılıç,Özgür Bulmuş,Emrah Özcan et al.
Aslı Karakılıç et al.
Vascular dementia (VaD), primarily caused by chronic cerebral hypoperfusion (CCH), is characterized by progressive cognitive decline associated with neurovascular dysfunction. The present study aimed to investigate whether systemic administ...
A novel synthetic peptide impairs spatial working memory in mice: A promising tool for dementia-related neurotoxicity animal models studies [0.03%]
一种新型合成肽可损害小鼠空间工作记忆：痴呆相关神经毒性动物模型研究的有力工具
José Mauro Moraes Dos Santos,Airam Barbosa de Moura,Eduarda Behenck Medeiros et al.
José Mauro Moraes Dos Santos et al.
The rapid aging of the global population is contributing to a sharp increase in dementia cases, with Alzheimer's disease (AD) accounting for the majority of diagnoses. The most widely accepted theory explaining AD pathogenesis is the amyloi...