Engineering mitochondrial lipoate metabolism through lpl A expression improves alpha-lipoic acid production in Pichia pastoris [0.03%]
通过lplA表达工程化线粒体硫胺基代谢以提高毕赤酵母中α-硫辛酸的产量
Fernando David Montalvo-Sandoval,Ana Sofía Salas Montantes,Ana Silvia Pérez-Martínez et al.
Fernando David Montalvo-Sandoval et al.
α-Lipoic acid (ALA) is an essential metabolic cofactor involved in oxidative metabolism and redox regulation, with increasing interest for its biotechnological production due to the limitations of chemical synthesis. In this study, we eval...
Sustainable biotransformation of acanthopanax senticosus to isofraxidin using deep eutectic solvents: decoding metabolic crosstalk through transcriptomic and metabolomic Integration [0.03%]
基于深度吴特溶剂的刺五加子座异荭草素生物转化及其转录组和代谢组分析
Shuang Jin,Huayong Zhao,Xiuhong Wu et al.
Shuang Jin et al.
A DES-assisted microbial transformation strategy integrating choline chloride/ethylene glycol-based deep eutectic solvent (DES) with Lactobacillus plantarum fermentation was developed to optimize isofraxidin yield from Acanthopanax senticos...
Harnessing iron nanoparticles for scalable cordycepin and adenosine production in Cordyceps militaris [0.03%]
利用铁纳米颗粒在塔宾曲霉中规模化生产cordycepin和腺苷
Shubhranshu Vardhan,Aruna Parihar,Deepesh Bhatt et al.
Shubhranshu Vardhan et al.
Cordyceps militaris (CM) is one of the most valuable edible mushrooms, treasured for its health promoting properties, largely due to cordycepin and adenosine. In the present experiments CM was cultivated on four different substrates (brown ...
Statistical optimization of ultrasound-microwave-assisted extraction for enhanced recovery of bacoside A3 from Bacopa monnieri [0.03%]
超声波-微波辅助提取巴戟天中巴卡苷A3的统计优化研究
Vennilavan Thirumavalavan,Nandhini Devi Ganesan
Vennilavan Thirumavalavan
Bacopa monnieri is a medicinal herb rich in triterpenoid saponins, particularly bacoside A3, which contribute to its neuropharmacological activity. In the present study, a combined ultrasound-microwave-assisted extraction (UMAE) strategy wa...
Controlled vs. non-controlled culture systems for SARS-CoV-2 VLP production using the baculovirus/SF9 platform [0.03%]
利用杆状病毒/Sf9平台生产SARS-CoV-2病毒样颗粒的受控与非受控培养系统比较研究
Luis Giovani de Oliveira Guardalini,Felipe Moura Dias,Thaissa Consoni Bernardino et al.
Luis Giovani de Oliveira Guardalini et al.
COVID-19 is an infectious disease resulting from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged as a global pandemic in 2020. Virus-like particles (VLP) are artificially generated nanoparticles composed of a...
Sustainable production of 2-phenylethanol by flower-isolated yeasts using agro-industrial wastes as feedstock [0.03%]
利用农业废弃物作为原料可持续生产苯乙醇
Stefany Kell Bressan,Anderson Giehl,Aline Perin Dresch et al.
Stefany Kell Bressan et al.
2-Phenylethanol (2-PE) is a commercially valuable aromatic alcohol, yet its sustainable bioproduction remains challenging due to low yields and high costs. This study initially analyzed the volatile organic compounds (VOCs) of eleven yeasts...
Antimicrobial and antioxidant activity of green synthesized copper nanoparticles [0.03%]
绿色合成铜纳米粒子的抗菌和抗氧化活性
Suresh Chand Mali,Anita Dhaka,Sheetal Sharma et al.
Suresh Chand Mali et al.
Copper nanoparticles (CuNPs) synthesized by crude extract of Enicostemma axillare and Celastrus paniculatus plants were evaluated for their antifungal and reactive oxygen species scavenging enzyme activities under in vitro and in vivo condi...
Profiling functional metabolites and minerals of fortified food black gram Vigna mungo (L.) hepper [0.03%]
强化食品黑偃麦草（L。）_hepper的功能代谢物和矿物质的特征分析
Smruti B Bhatt,Jaspreet Singh,Nagasathiya K et al.
Smruti B Bhatt et al.
This study is focused on analyzing and profiling the compounds from the fortified food of black gram and its ingredients. The metabolites and minerals with its oxides were studied using GC-MS, HPLC, LC-MS/MS, XRD, FTIR and ICP-OES. This stu...
Litsea cubeba essential oil: phytochemistry, bioactivity-driven applications and extraction [0.03%]
Litsea cubeba精油：植物化学、活性导向应用与提取方法
Xiaodong Guo,Xiaojie Yan,Qingshan Shi et al.
Xiaodong Guo et al.
This review provides a comprehensive overview of Litsea cubeba essential oil (EO), covering its extraction methods, compositional variation, bioactivities, and applications. It systematically examines both traditional (e.g., hydrodistillati...
Reduction and denaturation before affinity chromatography for host cell protein removal in aggregate-rich monoclonal antibody [0.03%]
用于富集聚集物的单克隆抗体生产过程中亲和层析前的宿主细胞蛋白去除方法研究——兼论还原和变性试验
Tianwei Huang,Changrui Zou,Guiping Qi et al.
Tianwei Huang et al.
Host cell proteins (HCPs) are important process-related safety concern factors during drug development, clinical trials and manufacturing, and their removal becomes particularly challenging when associated with antibody aggregates. Residual...