Nilay A Shah
Nilay A Shah
Donor lymphocyte infusion (DLI) is an important treatment modality in the management of relapsed hematological malignancies after allogeneic hematopoietic cell transplantation (allo-HCT). Donor T lymphocytes can be used in a therapeutic, pr...
Ariane Boumendil,Myriam Labopin
Ariane Boumendil
Blood-related diseases are complex diseases with diverse origins, treatments and prognosis. In haematology studies, investigators are interested in multiple outcomes and multiple prognostic variables that may change value over the course of...
Targeted cellular therapy for treatment of relapsed or refractory leukemia [0.03%]
靶向细胞疗法治疗复发或难治性白血病
Lauren D Scherer,Rayne H Rouce
Lauren D Scherer
While the mainstay of treatment for high-risk or relapsed, refractory leukemia has historically revolved around allogeneic hematopoietic stem cell transplant (allo-HSCT), targeted immunotherapies have emerged as a promising therapeutic opti...
The current landscape: Allogeneic hematopoietic stem cell transplant for acute lymphoblastic leukemia [0.03%]
当前allo-HSCT治疗急性淋巴细胞白血病的状况
Susan Prockop,Franziska Wachter
Susan Prockop
One of the consistent features in development of hematopoietic stem cell transplant (HCT) for Acute Lymphoblastic Leukemia (ALL) is the rapidity with which discoveries in the laboratory are translated into innovations in clinical care. Just...
Michael Grunwald,Belinda Avalos,Edward Copelan
Michael Grunwald
Ruta Brazauskas,Mary Eapen,Tao Wang
Ruta Brazauskas
Observational studies and clinical trials in hematology aim to examine treatments for blood disorders. The outcomes being studied must address the goals of the study and provide meaningful information about treatment course, disease progres...
The analysis of multiple outcomes, multiple variables and variables selection in hematopoietic cell transplantation studies [0.03%]
造血细胞移植研究中多结果、多因素和变量选择的分析
Soyoung Kim,Xi Fang,Kwang Woo Ahn
Soyoung Kim
It is common to study time-to-event data in cancer research such as hematopoietic cell transplantation (HCT) for leukemia. The extensive work has been done for the univariate survival outcome, that is, one event type. However, in practice a...
Zane Chiad,Aleksander Chojecki
Zane Chiad
Allogeneic hematopoietic stem cell transplantation (HSCT) is commonly utilized in the management of leukemia across multiple subtypes. Graft versus leukemia (GVL) is a critical component of successful transplantation and involves donor cell...
Diagnosis and management of mature B-cell lymphomas in children, adolescents, and young adults [0.03%]
儿童、青少年和年轻成人成熟B细胞淋巴瘤的诊断与治疗
Stanton Goldman,Mitchell S Cairo
Stanton Goldman
Mature B-cell lymphoma in children, adolescents and young adults comprises three major histological subtypes including in order of frequency Burkitt, germinal center diffuse large B-cell lymphoma and primary mediastinal B-cell lymphoma. The...
Maja Pohar Perme,Liesbeth C de Wreede,Damjan Manevski
Maja Pohar Perme
In many haematological diseases, the survival probability is the key outcome. However, when the population of patients is rather old and the follow-up long, a significant proportion of deaths cannot be attributed to the studied disease. Thi...