Sudhamsh Reddy Desai,Samarpana Chakraborty,Aditi Shastri
Sudhamsh Reddy Desai
Myeloid malignancies such as myelodysplastic syndrome (MDS) & acute myeloid leukemia (AML) are clonal diseases that emerge and progress due to the expansion of disease-initiating aberrant hematopoietic stem cells, that are not eliminated by...
Daniel Weisdorf,Najla El Jurdi,Shernan G Holtan
Daniel Weisdorf
Options for GVHD prophylaxis after allogeneic hematopoietic cell transplantation can best be chosen by understanding the pathophysiology of GVHD. Interventions to limit T cell activation, expansion and subsequent tissue injury can each be u...
Asparaginase dosing for obese patients with acute lymphoblastic leukemia and factors that contribute to outcomes [0.03%]
急性淋巴细胞白血病肥胖患者的天冬酰胺酶剂量以及影响预后的因素分析
Ryan D Cassaday
Ryan D Cassaday
Asparaginase in various forms is a standard part of the treatment of acute lymphoblastic leukemia (ALL) in children and adolescents. However, its use is more selective in adults. One of the key reasons is the toxicity observed from this cla...
The Australian Aplastic Anaemia and other Bone Marrow Failure Syndromes Registry [0.03%]
澳大利亚再生障碍性贫血和其他骨髓衰竭综合征注册中心
Lucy C Fox,Zoe K McQuilten,Frank Firkin et al.
Lucy C Fox et al.
The bone marrow failure syndromes (BMFS) are a diverse group of acquired and inherited diseases which may manifest in cytopenias, haematological malignancy and/or syndromic multisystem disease. Patients with BMFS frequently experience poor ...
Cardiac surgery for radiation associated heart disease in Hodgkin lymphoma patients [0.03%]
霍奇金淋巴瘤放射治疗后合并心脏病的外科治疗
Daniel Shell
Daniel Shell
Much of the modern focus of Hodgkin's Lymphoma (HL) treatment involves the prevention of secondary organ injury. Despite rationalisations of radiotherapy fields, many patients still develop late radiation-related cardiotoxicity that is seve...
Hodgkin Lymphoma: A disease shaped by the tumor micro- and macroenvironment [0.03%]
霍奇金淋巴瘤：由肿瘤微环境和宏环境造就的疾病
Rebecca Masel,Megan E Roche,Ubaldo Martinez-Outschoorn
Rebecca Masel
The tumor microenvironment (TMicroE) and tumor macroenvironment (TMacroE) are defining features of classical Hodgkin lymphoma (cHL). They are of critical importance to clinicians since they explain the common signs and symptoms, allow us to...
Yi Ning,Yanming Zhang,Michael A Kallen et al.
Yi Ning et al.
According to the 2022 World Health Organization (WHO) Classification (5th edition), the term myelodysplastic neoplasms (abbreviated MDS) has been introduced to replace myelodysplastic syndromes. MDS are a group of clonal hematopoietic stem ...
WHO, what, when, where, and why: New classification systems for acute myeloid leukemia and their impact on clinical practice [0.03%]
谁、什么、何时、何地和为什么：急性髓系白血病的新分类系统及其对临床实践的影响
Frederick R Appelbaum
Frederick R Appelbaum
The goal of a disease classification system is (or should be) to provide a tool for researchers and clinicians to study and treat the disease. The last decade has seen a markedly improved understanding of the pathophysiology of acute myeloi...
Joseph L Roswarski,Dan L Longo
Joseph L Roswarski
Hodgkin lymphoma (HL) is a highly curable B-cell malignancy of germinal center origin. Biologically it is a hematologic malignancy that is highly dependent on the immune microenvironment and utilizes immune escape through upregulation of th...
Myriam Labopin,Ariane Boumendil
Myriam Labopin