Thrombotic complications after haematopoietic stem cell transplantation: early and late effects [0.03%]
造血干细胞移植后的血栓并发症：早期和晚期效应
Dimitrios A Tsakiris,André Tichelli
Dimitrios A Tsakiris
Haematopoietic stem cell transplantation is currently the only curative option for many haematological malignancies, but is characterized by a wide spectrum of complications, including haemostatic changes. Bleeding and thrombotic events occ...
Marcel Levi
Marcel Levi
Disseminated intravascular coagulation (DIC) is a syndrome that may complicate a variety of diseases, including malignant disease. DIC is characterized by widespread, intravascular activation of coagulation (leading to intravascular fibrin ...
Francesca Elice,Francesco Rodeghiero,Anna Falanga et al.
Francesca Elice et al.
Recent advances in the understanding of the pathogenesis of cancer have led to the introduction of a variety of biological agents with novel mechanisms of action into clinical trials and even into clinical practice. In particular, tumour-as...
Thrombosis in childhood acute lymphoblastic leukaemia: epidemiology, aetiology, diagnosis, prevention and treatment [0.03%]
儿童急性淋巴细胞白血病的血栓形成：流行病学、病因、诊断、预防及治疗
Ulrike Nowak-Göttl,Gili Kenet,Lesley G Mitchell
Ulrike Nowak-Göttl
Acute lymphoblastic leukaemia (ALL) is the most common malignancy associated with venous thromboembolism (VTE) in children. The prevalence of symptomatic VTE ranges from 0% to 36%, and the variation can be explained, at least in part, by di...
Agnes Y Y Lee
Agnes Y Y Lee
Venous thromboembolism (VTE) is a major cause of morbidity and mortality in patients with cancer. Monotherapy with low-molecular-weight heparin is the recommended first-line approach in cancer patients with newly diagnosed VTE, and is usual...
Yona Nadir,Benjamin Brenner
Yona Nadir
Heparanase is an endo-beta-D-glucuronidase capable of cleaving heparan sulphate (HS) side chains of heparan sulphate proteoglycans on cell surfaces and the extracellular matrix; activity that is strongly implicated in tumour metastasis and ...
Janusz Rak,Chloe Milsom,Nathalie Magnus et al.
Janusz Rak et al.
The linkage between activation of the coagulation system and cancer is well established, as is deregulation of tissue factor (TF) by cancer cells, their vascular stroma and cancer-associated inflammatory cells. TF is no longer perceived as ...
Anat Aharon,Benjamin Brenner
Anat Aharon
Microvesicles comprised of exosomes and microparticles are shed from both normal and malignant cells upon cell activation or apoptosis. Microvesicles promote clot formation, mediate pro-inflammatory processes, facilitate cell-to-cell intera...
Anna Falanga,Marina Panova-Noeva,Laura Russo
Anna Falanga
Pathogenesis of the prothrombotic state of cancer patients is due, at least in part, to the ability of cancer cells to activate the coagulation system. Several complex and not fully recognized interactions between the malignant cell and the...
Gregory C Connolly,Alok A Khorana
Gregory C Connolly
The risk of venous thromboembolism (VTE) is elevated in cancer, and thrombosis is the second leading cause of death in patients with malignancy. Many risk factors for cancer-associated thrombosis have been identified. These include patient-...