Jack M Lionberger,Derek L Stirewalt
Jack M Lionberger
The complexity of the healthy haematopoietic system is immense, and as such, one must understand the biology driving normal haematopoietic expression profiles when designing experiments and interpreting expression data that involve normal c...
MicroRNA expression profiling in acute myeloid and chronic lymphocytic leukaemias [0.03%]
急性髓系白血病和慢性淋巴细胞白血病的微小核糖核酸表达谱分析
Guido Marcucci,Krzysztof Mrózek,Michael D Radmacher et al.
Guido Marcucci et al.
Altered expression of microRNAs, a new class of noncoding RNAs that regulate messenger RNA and protein expression of target genes, has been recently demonstrated to have an essential role in the process of leukaemogenesis. Distinctive patte...
Clinical implications of gene expression profiling in myelodysplastic syndromes: recognition of ribosomal and translational gene dysregulation and development of predictive assays [0.03%]
基因表达谱分析在骨髓增生异常综合征的临床意义：识别核糖体和翻译相关基因调控异常及预测性检测的发展
Naomi Galili,Azra Raza
Naomi Galili
Myelodysplastic syndromes (MDS) are a group of haematopoietic stem cell disorders that pose a unique challenge for gene expression profiling by virtue of their inherent heterogeneity. Despite monoclonality of MDS, the marrow picture is comp...
Carles Codony,Marta Crespo,Pau Abrisqueta et al.
Carles Codony et al.
The proliferation of new techniques that allow a multiparametric study of gene expression, the mutational state of genomic DNA, DNA methylation and the phosphorylation of receptor and adaptor proteins has led to an increased understanding o...
Javeed Iqbal,Zhongfeng Liu,Karen Deffenbacher et al.
Javeed Iqbal et al.
The classification of lymphoid malignancies has evolved from a purely morphological scheme to the current WHO (World Health Organization) classification, which takes into consideration histological, immunophenotypic, genetic and clinical in...
Agnes S M Yong,Junia V Melo
Agnes S M Yong
The use of microarray technology in chronic myeloid leukaemia (CML) has increased our understanding of the biology of this disease. From early studies of gene expression profiling in BCR-ABL-positive cell lines to samples from patients in d...
Ulrike Bacher,Alexander Kohlmann,Claudia Haferlach et al.
Ulrike Bacher et al.
In view of the genetic heterogeneity of acute myeloid leukaemia (AML), gene expression profiling (GEP) with the possibility of investigating the expression of tens of thousands of genes in parallel represents a promising approach to facilit...
Jerald Radich
Jerald Radich
Eytan Stein,Brandon McMahon,Hau Kwaan et al.
Eytan Stein et al.
Since the initial description of the disease, the life-threatening coagulopathy associated with acute promyelocytic leukaemia (APL) has been the defining clinical characteristic. Historically, this uncommon subtype of acute myeloid leukaemi...
A K Kakkar
A K Kakkar
Venous thromboembolism is a common complication in patients with malignant disease. The development of symptomatic thromboembolism is associated with a poor prognosis for patients with cancer. Retrospective analysis of studies comparing unf...