Moving from prognostic to predictive factors in chronic lymphocytic leukaemia (CLL) [0.03%]
慢性淋巴细胞白血病（CLL）从预后因素到预测因素的发展
Thorsten Zenz,Stefan Fröhling,Daniel Mertens et al.
Thorsten Zenz et al.
Many prognostic factors have been identified in chronic lymphocytic leukaemia (CLL). Based on the assessment of B cell receptor (BCR) structure and function, a subdivision into subtypes is possible (e.g., immunoglobulin heavy chain variable...
Clinical and diagnostic implications of monoclonal B-cell lymphocytosis [0.03%]
单克隆B细胞淋巴细胞增多症的临床和诊断意义
Andy C Rawstron,Peter Hillmen
Andy C Rawstron
Monoclonal B-lymphocytosis (MBL) is defined as the presence of a population of monoclonal B-cells, usually with a chronic lymphocytic leukaemia (CLL) phenotype, which comprise fewer than 5000 cells per microl with no evidence of tissue invo...
Clive S Zent,Neil E Kay
Clive S Zent
Patients with B-chronic lymphocytic leukaemia /small lymphocytic lymphoma (CLL) have a 5-10% risk of developing autoimmune complications, which primarily cause cytopaenia. These autoimmune cytopaenias can occur at any stage of CLL and do no...
Chronic lymphocytic leukaemia: a disease of activated monoclonal B cells [0.03%]
慢性淋巴细胞性白血病是一种单克隆B细胞活化疾病
Rajendra N Damle,Carlo Calissano,Nicholas Chiorazzi
Rajendra N Damle
B cell-type chronic lymphocytic leukaemia (CLL) has long been considered a disease of resting lymphocytes. However, cell surface and intracellular phenotypes suggest that most CLL cells are activated cells, although only a small subset prog...
M T S Bertilaccio,C Scielzo,M Muzio et al.
M T S Bertilaccio et al.
Chronic lymphocytic leukaemia (CLL) is characterised by accumulation of CD5(+) monoclonal B cells in primary and secondary lymphoid tissues. Genetic defects and stimuli originating from the microenvironment concur to the selection and expan...
Estella Matutes,Ayoma Attygalle,Andrew Wotherspoon et al.
Estella Matutes et al.
The diagnosis of chronic lymphocytic leukaemia (CLL) is based on clinical and laboratory features. Morphology and immunophenotype are the initial diagnostic investigations. In atypical cases, these tests should be complemented with molecula...
Advances in biology and therapy of chronic lymphocytic leukemia. Preface [0.03%]
慢性淋巴细胞性白血病生物学和治疗进展的序言
Emili Montserrat
Emili Montserrat
Joseph R Bertino
Joseph R Bertino
The antifolates aminopterin and methotrexate have two firsts in the treatment of malignancy. Aminopterin was the first drug reported to cause remissions in children with acute lymphocytic leukaemia, and methotrexate (MTX), the antifolate th...
Thrombotic thrombocytopenia purpura (TTP) and other thrombotic microangiopathies [0.03%]
血小板减少性紫癜（TTP）和其他微血管病性溶血性贫血
Joel Moake
Joel Moake
Thrombotoic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy characterised by systemic platelet aggregation, organ ischaemia, profound thrombocytopenia (with increased marrow megakaryocytes) and fragmentation of erythrocytes. ...
Role of reduced intensity transplant in adult patients with acute lymphoblastic leukemia: If and when? [0.03%]
成人急性淋巴细胞白血病减强度移植的作用：何时及用于谁？
Stephen J Forman
Stephen J Forman
Although allogeneic transplantation is a potentially curative therapy for adults with acute lymphoblastic leukemia (ALL), the high risk of the ablative regimen limits its use, especially in older patients where the need for better therapy i...