Haematopoietic transplants combining a single unrelated cord blood unit and mobilized haematopoietic stem cells from an adult HLA-mismatched third party donor. Comparable results to transplants from HLA-identical related donors in adults with acute leukaemia and myelodysplastic syndromes [0.03%]
单份无关脐带血加成年HLA半相合供者的动员造血干细胞的移植效果可媲美HLA全相合同胞 donor 的移植：成人急性白血病和骨髓增生异常综合征患者的治疗
Ana Sebrango,Isabel Vicuña,Almudena de Laiglesia et al.
Ana Sebrango et al.
We describe results of the strategy, developed by our group, of co-infusion of mobilized haematopoietic stem cells as a support for single-unit unrelated cord blood transplant (dual CB/TPD-MHSC transplants) for treatment of haematological m...
S S Tung,S Parmar,S N Robinson et al.
S S Tung et al.
Umbilical cord blood (UCB) has become an important source of hematopoietic stem cell transplant (HSCT) for hematologic malignancies in adults. Its ready availability, allowance of higher HLA disparity and lower incidence of graft-versus-hos...
The intra-bone marrow injection of cord blood cells extends the possibility of transplantation to the majority of patients with malignant hematopoietic diseases [0.03%]
脐血细胞骨髓内移植可使恶性血液病患者几乎人人适合移植
Francesco Frassoni,Riccardo Varaldo,Francesca Gualandi et al.
Francesco Frassoni et al.
Cord blood transplant (CBT) in adult patients is scarcely utilized because of the risk of graft failure or very delayed platelet recovery. To improve the capacity and the speed to engraft, we have developed an intra-bone (IB) cord blood tra...
Mitchell E Horwitz,Nelson Chao
Mitchell E Horwitz
Allogeneic umbilical cord blood (UCB) transplantation is an established alternative to unrelated bone marrow or peripheral blood transplantation for treatment of high-risk hematologic disorders. There is growing evidence that non-myeloablat...
Double cord blood transplantation: extending the use of unrelated umbilical cord blood cells for patients with hematological diseases [0.03%]
双份脐血移植治疗血液系统疾病的研究进展
Vanderson Rocha,Alessandro Crotta,Annalisa Ruggeri et al.
Vanderson Rocha et al.
Unrelated umbilical cord blood (UCB) has been widely used to treat patients lacking a well-matched HLA donor. Cell dose is a critical determinant of outcomes in cord blood transplantation, limiting the use of this strategy for low body weig...
Umbilical cord blood transplantation from unrelated donors in adult patients with chronic myeloid leukaemia [0.03%]
无关供者的脐带血移植治疗慢性粒细胞性白血病成人患者
Jaime Sanz,Guillermo F Sanz
Jaime Sanz
Allogeneic haematopoietic stem cell transplantation (HSCT) remains an important treatment option for patients with chronic myeloid leukaemia (CML) failing tyrosine-kinase inhibitors or progressing to an advanced phase. In this setting, umbi...
Alternative donors hematopoietic stem cells transplantation for adults with acute myeloid leukemia: Umbilical cord blood or haploidentical donors? [0.03%]
成人急性髓系白血病替代供者造血干细胞移植：脐带血或半相合供者？
Annalisa Ruggeri,Fabio Ciceri,Eliane Gluckman et al.
Annalisa Ruggeri et al.
Use of allogeneic transplantation for patients with acute myeloid leukemia (AML) depends mainly on the risk of the disease, and HLA matched donor availability. In patients with high-risk leukemia, in the absence of a HLA (human leukocyte an...
William Arcese,Francesco Buccisano,Raffaella Cerretti et al.
William Arcese et al.
Allogeneic haematopoietic stem cell transplantation represents a potential life-saving procedure for many patients affected by acute myeloid leukaemia. However, in the past its application has been limited by the availability of a HLA match...
Cord blood transplantation in children with haematological malignancies [0.03%]
儿童血液系统恶性肿瘤患者的脐带血移植治疗
Alice Bertaina,Maria Ester Bernardo,Maurizio Caniglia et al.
Alice Bertaina et al.
Umbilical cord blood transplantation (UCBT) is largely used to treat children affected by haematological malignant disorders. In comparison to bone marrow transplantation (BMT), advantages of UCBT include lower incidence and severity of gra...
Meghan Delaney,Karen K Ballen
Meghan Delaney
Transplantation with umbilical cord blood for haematological malignancy and other diseases has increased over the last two decades. The parameters that affect clinical outcome have been intensely studied in this relatively new clinical sett...