Richard M Stone
Richard M Stone
The choice of post-remission therapy for patients with acute myeloid leukemia (AML) depends on age, response to initial therapy, and on disease-related biology. High-dose ara-C (HIDAC) is the standard chemotherapy-based post-remission treat...
Alan D D&#x;Andrea
Alan D D&#x;Andrea
Cancer cells often have DNA repair pathway deficiencies, which render cancer more sensitive to treatment but can also cause resistance if the DNA repair pathway is restored. By using DNA repair pathway inhibitors, cancers can be resensitize...
Ari M Melnick
Ari M Melnick
Epigenetic regulation is known to affect gene expression, and recent research shows that aberrant DNA methylation patterning may play a role in leukemogenesis. All leukemias display aberrant distribution of cytosine methylation, which is mo...
Benjamin L Ebert
Benjamin L Ebert
Chromosomal deletions are common molecular events in myeloid malignancies. Heterozygous deletions may contain a tumor suppressor gene that undergoes homozygous inactivation or may contain one or more genes that alter the disease phenotype t...
Detection of fusion genes at the protein level in leukemia patients via the flow cytometric immunobead assay [0.03%]
采用流式细胞仪免疫磁珠法在白血病患者蛋白水平检测融合基因
E Dekking,V H J van der Velden,S Böttcher et al.
E Dekking et al.
Nowadays, the presence of specific genetic aberrations is progressively used for classification and treatment stratification, because acute leukemias with the same oncogenetic aberration generally form a clinically and diagnostically homoge...
Immunophenotyping in multiple myeloma and related plasma cell disorders [0.03%]
多发性骨髓瘤和相关浆细胞疾病免疫表型分型
Shaji Kumar,Teresa Kimlinger,William Morice
Shaji Kumar
Plasma cell disorders form a spectrum ranging from the asymptomatic presence of small monoclonal populations of plasma cells to conditions like plasma cell leukemia and multiple myeloma, in which the bone marrow can be replaced by the accum...
Immunohistochemical surrogates for genetic alterations of CCDN1, PML, ALK, and NPM1 genes in lymphomas and acute myeloid leukemia [0.03%]
淋巴瘤和急性髓系白血病中CCDN1、PML、ALK和NPM1基因遗传改变的免疫组化替代标志物
Brunangelo Falini,Maria Paola Martelli,Enrico Tiacci et al.
Brunangelo Falini et al.
The World Health Organization (WHO) classification of lympho-hemopoietic neoplasms is increasingly based on genetic criteria. Detection of tumor-associated primary genetic lesions is usually performed using the polymerase chain reaction (PC...
Edward D Ball,H Elizabeth Broome
Edward D Ball
Methods to generate monoclonal antibodies to antigens of neoplastic cells have revolutionized our understanding of cancer cell growth and differentiation, diagnosis, and treatment. Monoclonal antibodies derived by immunizing animals (mostly...
Multi-parameter fluorescence-activated cell sorting and analysis of stem and progenitor cells in myeloid malignancies [0.03%]
多参数荧光激活的细胞分选和髓系恶性肿瘤干祖细胞分析
Britta Will,Ulrich Steidl
Britta Will
Owing to the discovery that rare leukemia-initiating cells (or leukemia stem cells, LSC) give origin to and propagate a hierarchical cellular organization of variably differentiated leukemic blasts, the analysis of precisely defined stem an...