Germline predisposition to myeloid neoplasms: Characteristics and management of high versus variable penetrance disorders [0.03%]
血液肿瘤的种系易感性：高外显率和变异外显率疾病的特征及管理
Amy M Trottier,Simone Feurstein,Lucy A Godley
Amy M Trottier
Myeloid neoplasms with germline predisposition have been recognized increasingly over the past decade with numerous newly described disorders. Penetrance, age of onset, phenotypic heterogeneity, and somatic driver events differ widely among...
Francesco Passamonti,Giovanni Corrao,Gastone Castellani et al.
Francesco Passamonti et al.
Most new drug approvals are based on data from large randomized clinical trials (RCTs). However, there are sometimes contradictory conclusions from seemingly similar trials and generalizability of conclusions from these trials is limited. T...
Oraine Snaith,Corey Poveda-Rogers,Dorottya Laczko et al.
Oraine Snaith et al.
The diversity of genetic and genomic abnormalities observed in acute myeloid leukemia (AML) reflects the complexity of these hematologic neoplasms. The detection of cytogenetic and molecular alterations is fundamental to diagnosis, risk str...
Željko Antić,Jana Lentes,Anke K Bergmann
Željko Antić
The last five decades have witnessed significant improvement in diagnostics, treatment and management of children with acute lymphoblastic leukaemia (ALL). These advancements have become possible through progress in our understanding of the...
When to use which molecular prognostic scoring system in the management of patients with MDS? [0.03%]
何时在骨髓增生异常综合症患者的管理中使用哪种分子预后评分系统？
Tariq Kewan,Jan Philipp Bewersdorf,Carmelo Gurnari et al.
Tariq Kewan et al.
Myelodysplastic syndromes/neoplasms (MDS) are a heterogeneous group of hematopoietic cancers characterized by recurrent molecular alterations driving the disease pathogenesis with a variable propensity for progression to acute myeloid leuke...
Cytogenomics of B-cell non-Hodgkin lymphomas: The "old" meets the "new" [0.03%]
B细胞非霍奇金淋巴瘤的细胞基因组学：“旧”与“新”相遇
Marta Grau,Cristina López,José Ignacio Martín-Subero et al.
Marta Grau et al.
For the routine diagnosis of haematological neoplasms an integrative approach is used considering the morphology, and the immunophenotypic, and molecular features of the tumor sample, along with clinical information. The identification and ...
The role of randomized controlled trials, registries, observational databases in evaluating new interventions [0.03%]
随机对照试验、注册登记和观察性数据库在评估新的干预措施中的作用
Robert Peter Gale,Mei-Jie Zhang,Hillard M Lazarus
Robert Peter Gale
Approaches to comparing safety and efficacy of interventions include analyzing data from randomized controlled trials (RCTs), registries and observational databases (ODBs). RCTs are regarded as the gold standard but data from such trials ar...
Best practice & research clinical haematology: Screening for breast cancer in hodgkin lymphoma survivors [0.03%]
霍奇金淋巴瘤幸存者乳腺癌筛查临床实践与研究
Stephanie M Wong
Stephanie M Wong
Childhood and young adult survivors of Hodgkin lymphoma are at an elevated risk of developing breast cancer. Breast cancer risk is felt to originate from chest wall radiation exposure prior to the third decade of life, with incidence beginn...
Daniel A Pollyea
Daniel A Pollyea
Neal J Weinreb
Neal J Weinreb
Gaucher disease GD), is a rare lysosomal storage disorder caused by deficient acid β-glucosylceramidase activity and accumulation of glucosylceramide in tissue macrophages. With the 1991 advent of alglucerase enzyme replenishment therapy (...