Genevieve M Gerhard,Gottfried von Keudell
Genevieve M Gerhard
The rapid development of novel therapeutics in B-cell Non-Hodgkin's lymphoma (B-NHL) over the past decade has presented a critical inflection point for the field. Bispecific antibodies are one such therapeutic class emerging as an effective...
CARs for lymphoma [0.03%]
用于淋巴瘤治疗的CARs
Ishan J Tatake,Jon E Arnason
Ishan J Tatake
Chimeric Antigen Receptor (CAR)-T cell therapy has revolutionized treatment options for B-cell Non-Hodgkin Lymphoma (NHL). CD19-targeting CAR-T cell therapy is approved for treatment in Diffuse Large B Cell Lymphoma, Follicular Lymphoma, Ma...
Analyte heterogeneity analysis as a possible potency parameter for MSC [0.03%]
分析物异质性分析作为MSC潜在效力参数的可能性
David Kaplan,Eric Christian,Sarah Planchon Pope et al.
David Kaplan et al.
Mesenchymal stem/stromal cells (MSC) have been transplanted for therapeutic purposes with inconsistent results. MSC preparations are heterogeneous, and this person-to-person heterogeneity may account for the variable clinical outcomes. Addi...
CAR assembly line: Taking CAR T-cell manufacturing to the next level [0.03%]
CAR装配线：将CAR T细胞生产提升到下一个阶段
Jiasheng Wang,Paolo F Caimi
Jiasheng Wang
The widespread adoption of chimeric antigen receptor (CAR) T-cell therapy has been limited by complex, resource-intensive manufacturing processes. This review discusses the latest innovations aiming to improve and streamline CAR T-cell prod...
Erratum to "Special issue 37.2 and 37.3 Genetics and Function of HLA and immune-related genes in transplantation and cellular immunotherapy" [Best Pract Res Clin Haematol (2024) 101588] [0.03%]
《关于“特殊议题37.2和37.3 遗传学与HLA及相关免疫基因在移植及细胞免疫治疗中的功能”[最佳实践研究临床血液病学(2024)101588]的勘误》
Katharina Fleischhauer
Katharina Fleischhauer
Deciphering the role of the major histocompatibility complex, the intestinal microbiome and metabolites in the pathogenesis of acute graft-versus-host disease [0.03%]
解析主要组织相容性复合体、肠道微生物组及代谢产物在急性移植物抗宿主病发病机制中的作用
Valentin Wenger,Robert Zeiser
Valentin Wenger
Allogeneic hematologic stem cell transplantation is a cornerstone in modern hematological treatment, yet its efficacy is compromised by acute Graft-versus-Host Disease. In acute Graft-versus-Host Disease, conditioning regimen induced epithe...
Relevance of donor-specific HLA antibodies in hematopoietic cell transplantation [0.03%]
造血细胞移植中供者特异性HLA抗体的相关性
Thuong Hien Tran,Andreas Heinold,Magdalena Spackova et al.
Thuong Hien Tran et al.
Advances in hematopoietic cell transplantation have expanded the use of alternative donors such as haploidentical family donors or mismatched unrelated donors. However, donor-specific HLA antibodies (DSA) have been recognized as a significa...
From clones to immunopeptidomes: New developments in the characterization of permissive HLA-DP mismatches in hematopoietic cell transplantation [0.03%]
从克隆到免疫肽组：造血细胞移植中允许性HLA-DP不匹配表征的新进展
Esteban Arrieta-Bolaños
Esteban Arrieta-Bolaños
Mismatching at the HLA-DPB1 locus occurs frequently in hematopoietic cell transplantation with unrelated donors. Despite this, HLA-DPB1 allelic mismatches have traditionally not been considered in patient-donor matching. A T-cell epitope (T...
Interfering with KIR and NKG2A immune checkpoint axes to unleash NK cell immunotherapy [0.03%]
干扰KIR和NKG2A免疫检查点轴以释放NK细胞免疫疗法
Nicky A Beelen,Vera T C Valckx,Gerard M J Bos et al.
Nicky A Beelen et al.
Due to their intrinsic ability to eliminate malignant cells, natural killer (NK) cells emerge as a promising immunotherapy for cancer. While clinical studies have affirmed the safety of NK cell infusions and combination therapies have demon...
Special issue 37.3: "Genetics and function of HLA and immune-related genes in hematopoietic cell transplantation and cellular immunotherapy" [0.03%]
第37卷第3期：移植和细胞免疫治疗中“造血细胞移植和细胞免疫治疗中的HLA和相关免疫基因的功能与遗传学”专题刊
Katharina Fleischhauer
Katharina Fleischhauer