Precision immunomodulation: Understanding and harnessing cytokine pathways to treat and prevent immune-related adverse events (irAEs) [0.03%]
精准免疫调控：理解并利用细胞因子途径治疗和预防免疫相关不良事件（irAEs）
Matthew J Hadfield,Ross D Merkin,Sherin J Rouhani et al.
Matthew J Hadfield et al.
The utilization of immune checkpoint inhibitors has fundamentally changed both the treatment landscape for a multitude of malignancies as well as our understanding of cancer biology. Despite profound advancements, the utilization of these d...
Thomas R Spitzer,Hillard M Lazarus
Thomas R Spitzer
Cytokines are ubiquitous small proteins, secreted by virtually all leukocytes and other immune effector cells, that interact with other cytokines and effector and regulatory cells to direct innate and adaptive immunity. Six broad categories...
Smith Kungwankiattichai,Richard T Maziarz
Smith Kungwankiattichai
The discovery and development of cytokines and growth factors represent transformative events in modern medicine, spanning from early observations of immune mediators to current therapeutic applications. This review chronicles the historica...
Mesenchymal stem cells in hematology: Therapeutic initiatives and future directions [0.03%]
造血干细胞疗法及未来的发展方向
Portia Smallbone,Partow Kebriaei,Mayela Mendt et al.
Portia Smallbone et al.
In recent years, the landscape of hematology has undergone rapid transformation, driven by innovative therapeutic strategies harnessing the properties of novel cellular therapies. Mesenchymal stem cells (MSCs) represent one of these promisi...
Creating a GMP cell processing program: A focus on quality and regulation [0.03%]
打造GMP细胞处理项目：聚焦质量和规范
Darshan Patel,Jane Reese Koç,Folashade Otegbeye
Darshan Patel
Implementing current Good Manufacturing Practice (GMP) regulations and principles even in early phases of cell-based therapy studies is crucial for ensuring safety and reproducible quality of these products. This paper outlines the comprehe...
Anna Sergeeva,Wingchi K Leung,Lisa St John et al.
Anna Sergeeva et al.
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multifunctional cytokine integral to the differentiation, proliferation, and activation of various immune cells, especially those of myeloid lineage. Recombinant human GM-CSF (r...
Human mesenchymal stem cell therapy: Potential advances for reducing cystic fibrosis infection and organ inflammation [0.03%]
人 mesenchyme 干细胞治疗：减少囊性纤维化感染和器官炎症的潜在进展
Tracey L Bonfield,Hillard M Lazarus
Tracey L Bonfield
Innovation in cystic fibrosis (CF) supportive care, including implementing new antimicrobial agents, improved physiotherapy, and highly effective modulators therapy, has advanced patient survival into the 4th and 5th decades of life. Howeve...
James M Anderson
James M Anderson
Arnold Caplan was the father of MSC, mesenchymal stem cells. His pioneering efforts have led to significant advances in the utilization of mesenchymal stem cells for the treatment of a wide variety of clinical diseases. This reflection prov...
Cytokines in hematopoietic cell transplantation and related cellular therapies [0.03%]
细胞因子在血液系统干细胞移植和相关细胞治疗中的作用
Abdul-Hamid Bazarbachi,Markus Y Mapara
Abdul-Hamid Bazarbachi
Cytokines are pleiotropic molecules involved in hematopoiesis, immune responses, infections, and inflammation. They play critical roles in hematopoietic cell transplantation (HCT) and immune effector cell (IEC) therapies, mediating both the...
Hillard M Lazarus,Robert Peter Gale
Hillard M Lazarus
Radiological accidents/incidents are common with nearly 400 reported since 1944 exposing about 3000 people to substantial doses of ionizing radiations with 127 deaths. Damage to hematopoietic stem and progenitor cells with resulting bone ma...