Kanchi Patell,Katherine Myers,Amr Mohamed et al.
Kanchi Patell et al.
Adoptive cellular therapy, or the collection and transfer of immune cells to patients, is emerging as a treatment option for many malignancies, especially hematologic malignancies, with a growing role in solid tumors and non-malignant condi...
Yuchen Zhu,Kailin Xu,Ying Wang
Yuchen Zhu
Chimeric antigen receptor (CAR)-T cell therapy has proven to be a revolutionizing immunotherapeutic strategy for treating relapsed or refractory lymphoma, achieving remarkable clinical responses. However, there remain some challenges includ...
Applications and prospects of molecularly targeted drugs combined with CAR-T cell therapy to treat multiple myeloma [0.03%]
靶向药物联合CAR-T细胞治疗多发性骨髓瘤的应用和前景
Yan Xu,Jianping Mao
Yan Xu
Chimeric antigen receptor T (CAR-T) cell therapy, a type of precision immunotherapy, has shown promising outcomes in treating certain types of cancers, although limited by the antigen escape, suppression on the tumor microenvironment (TME),...
Mohammadamin Noorafrooz,Robert Peter Gale,Ramin Noorafrooz et al.
Mohammadamin Noorafrooz et al.
Chimeric antigen receptor-natural-killer (CAR-NK)-cells are a promising cancer cell therapy. Several features of CAR-NK-cells are suggesting an advantage over CAR-T-cells such as less complex manufacturing, "off-the-shelf" use and lower ris...
Alexandra Haugh,Matthew J Frigault
Alexandra Haugh
Cytokines play an integral role in both promoting the efficacy of immune effector cell (IEC) therapies and in the development of the unique spectrum of associated toxicities, including CRS, ICANS, and IEC-HS. We review the various cytokines...
Andre Souffrant,Avery Wilson,Bryar Hansen et al.
Andre Souffrant et al.
Transplantation tolerance is an immunologic state in which a transplant recipient's immune system does not mount a destructive immune response to an allograft. Tolerance offers an alternative to lifelong immunosuppression, potentially exten...
Immune reconstitution following allogeneic hematopoietic cell transplantation and CAR-T therapy: dynamics, determinants, and directions [0.03%]
allo-HSCT和CAR-T治疗后的免疫重建：动态、决定因素及发展方向
Weijia Fu,Jiahao Chen,Xiaoxia Hu
Weijia Fu
Immune reconstitution (IR) is a dynamic and sequential process that occurs after allogeneic hematopoietic cell transplantation (allo-HCT) and cellular therapies, involving the gradual recovery of both innate and adaptive immune compartments...
Research progress of targeted BCMA CAR-T therapy for relapsed/refractory multiple myeloma antigen-negative relapse [0.03%]
靶向BCMA的CAR-T治疗复发/难治多发性骨髓瘤抗原阴性复发病理研究进展
Lulu Kong,Kailin Xu,Wei Chen
Lulu Kong
Chimeric antigen receptor T cell (CAR-T) therapy targeting B-cell maturation antigen (BCMA) has emerged as a novel and effective modality for the treatment of relapsed or refractory multiple myeloma (RRMM), achieving remarkable therapeutic ...
Cytokines in hematology, hematopoietic cell transplantation and immune effector cell therapy: Preface [0.03%]
血液学、造血细胞移植和免疫效应细胞治疗中的细胞因子：前言
Thomas R Spitzer,Hillard M Lazarus,Robert Peter Gale
Thomas R Spitzer
Advancing MSC therapy: The next generation of potent mesenchymal stromal cells for systemic autoimmune rheumatic diseases [0.03%]
间充质干细胞治疗的进步：下一代系统性自身免疫风湿病的高效间质干细胞
Hulya Bukulmez,Kristin B Highland,Rujman Khan et al.
Hulya Bukulmez et al.
Fields that deal with systemic autoimmune diseases such as rheumatology, gastroenterology, and endocrinology have adopted the principles of immune modulation, including shifting immune activation sates, from advances originally developed in...