Capecitabine combined with immunotherapy as maintenance therapy improves survival in recurrent/metastatic nasopharyngeal carcinoma: a retrospective cohort study [0.03%]
卡培他滨联合免疫治疗作为复发/转移性鼻咽癌维持治疗可改善生存率：一项回顾性队列研究
Shui-Qing He,Ying Huang,Ze-Yu Zhao et al.
Shui-Qing He et al.
Background: We evaluated the clinical impact of combining capecitabine with immunotherapy (Immu/Cape) compared to immunotherapy monotherapy (Immu) as maintenance in recurrent/metastatic (R/M) nasopharyngeal carcinoma (NPC...
Fibroblast growth factor signals drive the metastatic behavior in small cell lung cancer [0.03%]
成纤维细胞生长因子信号驱动小细胞肺癌的转移行为
Büsra Ernhofer,Anna Solta,Julia Sinner et al.
Büsra Ernhofer et al.
Background: Early metastatic spread represents a challenge in fighting small cell lung cancer (SCLC). The molecular mechanisms underlying metastatic dissemination remain unclear in this devastating disease. ...
Urothelium marker UPK2 identifies aggressive colorectal cancers with distinct molecular and histological features [0.03%]
尿路上皮标志物UPK2用于识别具有独特分子和组织学特征的侵袭性结直肠癌
Ville K Äijälä,Jouni Härkönen,Päivi Sirniö et al.
Ville K Äijälä et al.
Background: Uroplakin-2 (UPK2) is a relatively specific marker for urothelial cancer, often used in the differential diagnosis of tumors of unknown origin. UPK2 expression has been observed in colorectal cancers (CRCs), p...
Sorafenib plus selective internal radiotherapy with 90Y resin microspheres for the treatment of uveal melanoma with liver metastasis: a phase I trial [0.03%]
雷莫司尤单抗联合90Y树脂微球选择性体内放射治疗脉络膜恶性黑色素瘤肝转移的Ⅰ期临床研究
Grégoire Berthod,Christophe Cisarovsky,Tatiana Petrova et al.
Grégoire Berthod et al.
Introduction: Selective internal radiation therapy (SIRT) and sorafenib are used for patients with liver metastases from uveal melanoma. We conducted a phase I study to determine the optimal timing of administration of so...
ColoStem, a core oncofetal signature that identifies poor prognosis colorectal tumors [0.03%]
一种鉴定预后不良结直肠肿瘤的核心癌胎蛋白标志物ColoStem
Laura Solé,Eric Canton,María Maqueda et al.
Laura Solé et al.
Background: We have previously shown that non-curative chemotherapy imposes fetal conversion and high metastatic capacity to cancer cells. Analysis of public colorectal cancer datasets confirms the existence of a oncofeta...
RNLS hypomethylation as a potential epigenetic marker of lung cancer metastasis: an epigenome-wide association study [0.03%]
RNA去甲基化作为潜在的肺癌转移表观遗传标志物：一项表观基因组范围关联研究
Zhuangjie Guo,Jinkun Chen,Siyu Zhang et al.
Zhuangjie Guo et al.
Background: Lung cancer is highly lethal because most patients have already developed metastases at diagnosis, yet the epigenetic mechanisms driving metastasis are unclear. ...
Spatial molecular analyses reveal key features associated with response to KN026 in advanced HER2-positive breast cancer [0.03%]
空间分子分析揭示了KN026治疗HER2阳性晚期乳腺癌的疗效相关的关键特征
Jianli Ma,Shengnan Sun,Xiaowen Tang et al.
Jianli Ma et al.
Background: KN026 is a novel bispecific HER2-targeting antibody for HER2-positive recurrent or metastatic breast cancer that showed prolonged median PFS and lessened distinction of PFS regarding the HR subgroup in our pha...
Multizonal intraepithelial neoplasia of the lower genital tract and anus in women: terminology for defining the disease, an introduction by the British Society for Colposcopy and Cervical Pathology (BSCCP), International Anal Neoplasia Society (IANS), European Federation for Colposcopy (EFC) and British Society for the Study of Vulval Disease (BSSVD) sc [0.03%]
女性下生殖道和肛管多区域上皮内瘤变的疾病定义术语：英国阴道镜和宫颈病理学会(BSCCP)、国际肛门肿瘤学协会(IANS)、欧洲阴道镜联合会(EFC)及英国外阴病研究学会(BSSVD)介绍
Sarah J Bowden,Laura Burney Ellis,Tamzin Cuming et al.
Sarah J Bowden et al.
Multizonal anogenital intraepithelial neoplasia (MZIN) is an uncommon chronic pre-malignant condition. In the United Kingdom (UK) and elsewhere MZIN is managed by a variety of clinical specialities with differing strategies, resulting in a ...
The relationship between gut microbiota, lifestyle habits, and early-onset colorectal cancer: shedding light on early prediction [0.03%]
肠道微生物群、生活方式与早发性结直肠癌的关系：早期预测的启示
Jia-Wen Deng,Yi-Lu Zhou,Ya-Xuan Zhang et al.
Jia-Wen Deng et al.
Background: The development of early-onset colorectal cancer (EO-CRC) is linked to environmental exposures and gut microbiota alterations. We aimed to discover the connection and develop prediction strategies. ...
Survival outcomes of ERBB2-amplified metastatic colorectal cancer treated with first-line chemotherapy [0.03%]
表皮生长因子受体2基因扩增的转移性结直肠癌一线化疗患者的生存分析
Yuki Matsubara,Hideaki Bando,Yoshiaki Nakamura et al.
Yuki Matsubara et al.
Background: HER2-positive or ERBB2 amplified (ERBB2 amp+) metastatic colorectal cancer (mCRC) is an important subgroup due to emerging HER2-targeted therapies. Although ERBB2 amplification is associated with anti-EGFR ant...