A prospective investigation of early-onset colorectal cancer risk factors-pooled analysis of three large-scale European cohorts [0.03%]
早期结直肠癌风险因素的前瞻性调查——三大欧洲队列的合并分析
Ruhina S Laskar,Neil Murphy,Pietro Ferrari et al.
Ruhina S Laskar et al.
Background: Colorectal cancer (CRC) incidence is rising among adults under 55 years, but its causes remain unclear. Large-scale prospective studies are needed to identify risk factors for early-onset CRC (EOCRC). ...
Correction: Relative telomere length and senescence-associated inflammatory cytokines as blood-based prognostic markers in patients with advanced or resectable gastro-oesophageal adenocarcinoma [0.03%]
订正：相对端粒长度和衰老相关炎性细胞因子作为晚期或可切除食管胃腺癌的血液生物标志物
Alan E Bilsland,Eilidh McCulloch,Sofie Degerman et al.
Alan E Bilsland et al.
Published Erratum
British journal of cancer. 2025 Dec 19. DOI:10.1038/s41416-025-03298-6 2025
Neoplasm risk in individuals with neurofibromatosis 1 - a Danish nationwide cohort study with long-term follow-up [0.03%]
I型神经纤维瘤病患者的肿瘤风险——一项丹麦全国队列研究及长期随访研究
Mia Aagaard Doherty,Kathrine Grell,Hanne Hove et al.
Mia Aagaard Doherty et al.
Background: As larger population-based studies assessing neoplasm risk in neurofibromatosis 1 (NF1) are limited, we aimed to evaluate overall neoplasm risk, specific cancer types, and second primary cancers. ...
Integrating lymphovascular invasion and ypTNM staging system for esophageal squamous cell carcinoma undergoing neoadjuvant chemoradiotherapy and surgery: a multi-institutional analysis [0.03%]
术前放化疗后食管鳞癌淋巴管血管侵犯与病理分期系统的多中心研究分析
Shiliang Liu,Yujin Xu,Xufeng Guo et al.
Shiliang Liu et al.
Purpose: Evidence on the prognostic and staging effects of lymphovascular invasion (LVI) after neoadjuvant chemoradiotherapy for esophageal squamous cell carcinoma (ESCC) is limited. We aimed to determine the prognostic v...
Senescence-related gene signature predicts prostate cancer progression and identifies PCNA as a therapeutic target via multi-omics machine learning integration [0.03%]
基于多组学机器学习整合的衰老相关基因特征谱预测前列腺癌进展并鉴定PCNA为治疗靶点
Renxuan Lin,Hiocheng Un,Youmei Kang et al.
Renxuan Lin et al.
Background: Senescence plays a critical role in prostate cancer, influencing disease onset and progression. However, the alterations of senescence-associated genes during prostate cancer progression and their potential va...
Extranodal extension in lung adenocarcinoma: pathological insights and its implication as a histological marker of clinical aggressiveness [0.03%]
肺腺癌的淋巴结外扩散：病理学见解及其作为临床侵袭性组织学标志物的意义
Shunta Tsuchida,Tetsuro Taki,Kotaro Nomura et al.
Shunta Tsuchida et al.
Background: Extranodal extension (ENE) is a recognized adverse prognostic factor in several malignancies, but its pathological basis and clinical significance in lung adenocarcinoma (LUAD) remain poorly understood. ...
Circulating tumour DNA for a minimal residual disease assessment and recurrence risk in hepatocellular carcinoma: a systematic review and meta-analysis [0.03%]
循环肿瘤DNA对肝细胞癌的最小残留疾病评估及复发风险的影响：系统性回顾和meta分析
Isabella R Buonopane,Erick F Saldanha,Júnior Samuel Alonso de Menezes et al.
Isabella R Buonopane et al.
Hepatocellular carcinoma (HCC) relapse remains high after curative-intent treatment due to occult minimal residual disease. Circulating tumour DNA (ctDNA) has emerged as a noninvasive biomarker. Systematic search of MEDLINE, EMBASE and the ...
Transgelin defines pro-tumorigenic cancer-associated fibroblasts in pancreatic cancer [0.03%]
肿瘤相关成纤维细胞定义胰腺癌中的促肿瘤型癌症相关成纤维细胞
Xingxing Wang,Keiko Shinjo,Kohei Kumegawa et al.
Xingxing Wang et al.
Introduction: Pancreatic ductal adenocarcinoma (PDAC) is characterised by a pronounced desmoplastic reaction, predominantly composed of cancer-associated fibroblasts (CAFs), including myofibroblastic CAFs (myCAFs). ...
CD44 upregulation in chronic liver disease marks the transition to hepatocellular carcinoma and portends poor prognosis [0.03%]
CD44在慢性肝病中上调标志着向肝细胞癌的转变并预示不良预后
Rui Dong,Akshaya Srikanth,Umesh Tharehalli et al.
Rui Dong et al.
Background: Hepatocellular carcinoma (HCC) often arises from chronic liver disease, but early biomarkers of malignant transformation are lacking. CD44, a transmembrane glycoprotein with multiple isoforms, has been implica...
Targeting Bcl-xL to eliminate chemotherapy-induced tumor dormancy and prevent breast cancer metastasis [0.03%]
靶向Bcl-xL以消除化疗引起的肿瘤休眠及预防乳腺癌转移
Kinjal Gupta,Nicholas Koelsch,Victoria Neely et al.
Kinjal Gupta et al.
Chemotherapy-induced tumor dormancy is a major barrier to curative cancer therapy, particularly in triple-negative breast cancer (TNBC), where dormant residual cells evade treatment and fuel late relapses. To define survival mechanisms sust...