PD-1 inhibitor improves radiosensitivity by tumor vessel normalization [0.03%]
PD-1抑制剂通过肿瘤血管正常化提高放射敏感性
Shengnan Hao,Dashan Ai,Quanxin Wang et al.
Shengnan Hao et al.
Background: Host immunity status and hypoxia are the hallmarks of radiosensitivity. Induction of anti-PD-1 immunotherapy demonstrates promise in locally advanced tumor radiotherapy, but whether anti-PD-1 immunotherapy imp...
Efficacy and safety of tislelizumab combined with chemotherapy for locally advanced penile cancer: a prospective, single-arm clinical study [0.03%]
替雷利珠单抗联合化疗治疗局部晚期阴茎癌的疗效和安全性：一项前瞻性、单臂临床研究
Xingli Shan,Hongsong Bai,Houshan Ning et al.
Xingli Shan et al.
Background: Locally advanced penile squamous cell carcinoma (PSCC) generally has a poor prognosis. Our aim was to access the efficacy and safety of programmed cell death protein 1 (PD-1) inhibitor tislelizumab combined wi...
Lifetime risk of solid tumors and leukemia in Down Syndrome: a population-based Swedish matched cohort study [0.03%]
瑞典人群匹配队列研究中的唐氏综合征患者一生中患实体瘤和白血病的风险
Alexandra Wachtmeister,Benedicte Bang,Ida Nordgren et al.
Alexandra Wachtmeister et al.
Background: Individuals with Down syndrome have an elevated risk of childhood leukaemia and are suggested to have a reduced risk of solid tumours in adulthood. However, it remains unclear which cancer subtypes contribute ...
Pan-cancer analysis of pyrimidine metabolism reveals signaling pathways connections with chemoresistance role [0.03%]
泛癌分析发现嘧啶代谢、信号通路及化疗耐药之间的联系
Vignesh Ramesh,Mert Demirdizen,Luisa Pinna et al.
Vignesh Ramesh et al.
Background: Deregulated pyrimidine metabolism (PyMet) contributes to various tumorigenic features of cancer, including chemoresistance and epithelial-to-mesenchymal transition. However, cancer often encompasses complex si...
Breast cancer incidence and subtype patterns among BRCA-mutated ovarian cancer patients: a systematic review and meta-analysis [0.03%]
BRCA突变型卵巢癌患者的乳腺癌发病率及亚型模式：系统评价和meta分析
Pedro Henrique de Souza Wagner,Gustavo Tadeu Freitas Uchôa Matheus,Danilo Monteiro Ribeiro et al.
Pedro Henrique de Souza Wagner et al.
Background: BRCA1 and BRCA2 are tumor suppressor genes essential for DNA repair. Mutations in these genes significantly increase breast (BC) and ovarian cancer (OC) risk, with BRCA1-positive facing a 70% BC and 40% OC lif...
Exploratory analysis of gene aberrations and chemotherapy response: findings from a real-world database in Japan [0.03%]
来自日本真实世界数据库的基因异常和化疗反应的探索性分析结果
Naoya Ishibashi,Takashi Kamatani,Satoru Aoyama et al.
Naoya Ishibashi et al.
Background: Chemotherapy selection traditionally relies on tumor tissue of origin. However, since genetic alterations drive tumor behavior, it remains unclear if mutations can better predict response. We hypothesized that...
High-dose chemotherapy in male germ cell cancer patients-a study by the SWENOTECA group [0.03%]
男性生殖细胞肿瘤的高剂量化学治疗--SWENOTECA研究组的一项研究报告
Anna K Jansson,Gabriella Cohn-Cedermark,Helene F S Negaard et al.
Anna K Jansson et al.
Background: World-wide consensus is lacking regarding patient selection and timing of high-dose chemotherapy (HDCT) with autologous stem-cell support in males with germ cell cancer (GCC). However, within the Swedish and N...
Effects of mitotically active polyploid giant cancer cells on chemoresistance through interaction with cancer-associated fibroblasts [0.03%]
有丝分裂活跃的多倍体巨癌细胞通过与癌症相关成纤维细胞相互作用诱导化学抗性的作用机制研究
Go Itoh,Yuma Fukushi,Kurara Takagane et al.
Go Itoh et al.
Background: Polyploid giant cancer cells (PGCCs), characterized by enlarged or multiple nuclei, have long been considered non-proliferative and hallmarks of high malignancy. However, their functional contribution to tumor...
High-dose vitamin D supplementation and prostate cancer progression: a phase II randomised trial in localised prostate cancer cases with intermediate risk of progression (ProsD) [0.03%]
高剂量维生素D补充与前列腺癌进展：局部晚期前列腺癌患者中度进展风险病例的II期随机试验(ProsD)
Visalini Nair-Shalliker,David P Smith,Val Gebski et al.
Visalini Nair-Shalliker et al.
Background: The ProsD trial aimed to determine if oral vitamin D supplementation could prevent prostate cancer (PC) progression in men on active surveillance (AS). ...
Intratumoral microbiome and pancreatic cancer: an enabling hallmark and path to novel treatments? [0.03%]
肿瘤微生物组与胰腺癌：一种新的标志性特征及潜在治疗途径？
Malte Carstensen,Lisa-Marie Philipp,Meghna Basu et al.
Malte Carstensen et al.
In 2022, Hanahan integrated polymorphic microbiomes to the hallmarks of cancer, resulting in 14 overarching features that are considered fundamental to initiation and progression of cancers. It is well acknowledged that genomic instability/...