The current state of polygenic scores for the development of lung cancer: a systematic review and validation in UK Biobank [0.03%]
多基因评分在肺癌发病机制中的应用现状：系统性回顾及英国生物银行数据验证结果
Bayan Galal,Joe Dennis,Antonis C Antoniou et al.
Bayan Galal et al.
Background: Risk-stratified lung cancer screening programs identify high-risk individuals who use tobacco but do not account for underlying genetic susceptibility. Many polygenic scores (PGS) have been developed for lung ...
Stage I non-small cell lung cancer: improving patient selection for minimally invasive lobectomy or stereotactic ablative radiotherapy based on clinical characteristics [0.03%]
基于临床特征选择早期非小细胞肺癌患者进行微创肺叶切除或立体定向消融放疗
Julianne Cynthia de Ruiter,Vincent van der Noort,Judi Nani Annet van Diessen et al.
Julianne Cynthia de Ruiter et al.
Background: We aimed to identify patient and tumour characteristics associated with differential benefit from minimally invasive lobectomy (MIL) or stereotactic ablative radiotherapy (SABR) for stage I non-small cell lung...
Efficacy and safety of low- and high-intensity focused ultrasound in glioblastoma: a systematic review of preclinical and clinical studies [0.03%]
低强度和高强度聚焦超声治疗胶质母细胞瘤的疗效与安全性：基于临床前研究和临床试验的系统综述
Muteb Alrashidi,Febe Ferro,Anas Almohammadi et al.
Muteb Alrashidi et al.
Background: Glioblastoma (GBM) is an aggressive brain tumour with a poor prognosis despite existing multimodal treatments, limited by the blood-brain barrier (BBB) and high recurrence rates. Focused ultrasound (FUS), enco...
Effects of personalized vitamin D3 on inflammation in colorectal cancer patients: a randomized trial [0.03%]
维生素D3对结直肠癌患者炎症影响的随机对照试验研究
Tafirenyika Gwenzi,Alexander N R Weber,Kira Trares et al.
Tafirenyika Gwenzi et al.
Background: Low vitamin D status and inflammation are associated with poor prognosis among colorectal cancer (CRC) patients. We assessed the efficacy of personalized vitamin D3 supplementation (VIDS) for reducing inflamma...
HDAC5 stabilization by tubeimoside I suppresses cervical cancer metastasis via inhibiting H3K27ac/KPNA2 axis [0.03%]
管仲苷I通过稳定HDAC5抑制宫颈癌转移的作用及机制研究
Mao Wang,Jiawu Fan,Baoquan Mu et al.
Mao Wang et al.
Background: Cervical cancer poses a significant threat to women's health, and its metastasis is one of the leading causes of cancer-related deaths. Tubeimoside I (TBMS1) is a traditional Chinese medicinal herb with antica...
Transient centrosome loss in cultured prostate epithelial cells induces chromosomal instability to produce an oncogenic genotype that correlates with poor clinical outcomes [0.03%]
瞬时中心体丢失可诱导前列腺上皮细胞产生染色体不稳定性并形成致癌基因型，这与较差的临床结果相关
Jiawen Yang,John M Ryniawec,Diogo de Oliveira Pessoa et al.
Jiawen Yang et al.
Background: Chromosomal instability (CIN) is a hallmark of prostate cancer that strongly correlates with metastatic burden and appears prominently in both primary cancer and metastatic disease. Low Gleason score primary p...
The breast cancer risk assessment pathway in England: a systems analysis of current challenges and ways to improve [0.03%]
英国的乳腺癌风险评估途径：当前挑战及改善方法的系统分析
Maria Valasaki,Lily C Taylor,Victoria G Woof et al.
Maria Valasaki et al.
Background: In England, NICE guidance recommends enhanced screening and prevention for women at increased breast cancer risk. This study aimed to map current risk assessment pathways for women under 50, explore existing c...
Favorable histo-molecular remodeling of pancreatic ductal adenocarcinoma after neoadjuvant FOLFIRINOX followed by high-dose stereotactic body radiotherapy [0.03%]
新辅助FOLFIRINOX治疗后接受高剂量立体定向体部放射治疗的胰腺导管腺癌的有利组织分子重构
Christelle Bouchart,Oier Azurmendi Senar,Julie Navez et al.
Christelle Bouchart et al.
Background: Combining high-dose stereotactic body radiation therapy (SBRT) with FOLFIRINOX (FFX) is promising as neoadjuvant strategy for pancreatic ductal adenocarcinoma (PDAC). This study provides an in-depth histo-mole...
Sarah Michael,John Broggio,Sarah Bowers et al.
Sarah Michael et al.
The effect of involved margins after breast cancer surgery on distant recurrence (DR) is unknown. We determined the association between margin width or involvement, DR and cancer deaths. ...
Targeting the DNA damage response prevents regrowth of colorectal peritoneal metastasis-derived organoids following treatment with mitomycin C [0.03%]
靶向DNA损伤反应可防止丝裂霉素C治疗后结直肠癌腹膜转移类器官的再生生长
Kyah van Megesen,Arianna Stefan,Madelief Kieboom et al.
Kyah van Megesen et al.
Background: A minority of Colorectal Cancer (CRC) patients with peritoneal metastases is eligible for cytoreductive surgery (CRS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC). However, recurrence rates ar...