Modelled impact of a multi-cancer early detection screening programme on the demand for diagnostics in England [0.03%]
一项多癌症早期检测筛查项目的模拟影响及其对英格兰诊断需求的影响
Joanne Martin,David A Jones,Libby Ellis et al.
Joanne Martin et al.
Background: People with a cancer signal detected via multi-cancer early detection (MCED) screening need timely access to confirmatory diagnostic testing. We estimated the likely change in demand for diagnostic testing in ...
Fasting-mimicking diet induces IFNβ secretion in tumor-associated macrophages via NRF1-mediated ubiquitin-dependent proteolysis of Trex1 [0.03%]
模拟禁食的饮食通过NRF1介导的Trex1泛素依赖性蛋白酶解诱导肿瘤相关巨噬细胞分泌IFNβ
Jiakun Li,Wenjiao Jiang,Guowei Tu et al.
Jiakun Li et al.
Background: Fasting-mimicking diet (FMD) is a safe and effective strategy in clinical oncology via metabolically restricting tumour growth and remodelling the immunity. To date, few studies have investigated the impact of...
Immunosuppressive immune microenvironment landscapes in VISTA-high gastric cancer [0.03%]
胃癌VISTA高表达的免疫抑制性免疫微环境特征
Yiming Luo,Haoxin Peng,Qian Yao et al.
Yiming Luo et al.
Background: V-domain Ig-containing suppressor of T cell activation (VISTA) is an immune checkpoint molecule predominantly expressed on myeloid cells and has recently been recognised as a key mediator of immunosuppression ...
Retraction Note: CDK5RAP3 as tumour suppressor negatively regulates self-renewal and invasion and is regulated by ERK1/2 signalling in human gastric cancer [0.03%]
撤回 notice:CDK5RAP3 作为肿瘤抑制因子通过抑制自我更新和侵袭并在人类胃癌中通过 ERK1/2 信号调节自身调控自我更新和入侵并由人类胃癌中的 ERK1 / 2 信号调节
Jian-Xian Lin,Changhwan Yoon,Ping Li et al.
Jian-Xian Lin et al.
Correction: Exposure-response relationship of cabozantinib in patients with metastatic renal cell carcinoma treated in routine care [0.03%]
校正：卡博替尼治疗转移性肾细胞癌患者的暴露反应关系
Benoit Blanchet,Alexandre Xu-Vuillard,Anne Jouinot et al.
Benoit Blanchet et al.
Published Erratum
British journal of cancer. 2026 Jan 20. DOI:10.1038/s41416-025-03335-4 2026
Effects of preoperative recombinant Interleukin 2-based immunomodulation on outcome after gastrointestinal cancer surgery: a systematic review and meta-analysis [0.03%]
术前基因重组白细胞介素-2免疫调节对胃肠癌手术结果影响的系统评价和meta分析
A Horcicka,N Bewersdorf,E Kalkum et al.
A Horcicka et al.
Background: Patients undergoing gastrointestinal cancer surgery are often immunocompromised and susceptible to infectious complications. Recombinant Interleukin 2 activates effector immune cells and stimulates the expansi...
INHBA, regulated by C/EBPβ, induces M2 macrophage polarization to promote tumor metastasis and growth via activating the PI3K/AKT pathway in gastric cancer [0.03%]
C/EBPβ调节的INHBA通过激活PI3K / AKT途径促进胃癌肿瘤转移和增殖诱导M2型巨噬细胞极化
Duan-Bo Shi,Yong-Chao Qin,Sen Liu et al.
Duan-Bo Shi et al.
Background: Gastric cancer (GC) is one of the most common malignant tumors with poor overall survival (OS). The mechanism underlying the progression of GC needs to be investigated in depth. ...
Tumour immune contexture and immune evasion in sporadic and Lynch syndrome-associated microsatellite unstable colorectal cancers [0.03%]
散发和林奇综合征相关微卫星不稳定型结直肠癌的肿瘤免疫浸润及其逃逸机制
Samantha Martin,Hanna Elomaa,Juha P Väyrynen et al.
Samantha Martin et al.
Background: The high mutational burden in microsatellite unstable colorectal cancers (MSI CRCs) results in high immunogenicity, yet response rates to immunotherapy vary, suggesting underlying heterogeneity of the tumour i...
Diagnostic whole transcriptome sequencing in a series of 1233 FFPE solid tumor samples [0.03%]
1233例石蜡包埋组织样本的诊断型全转录组测序分析
Markus Ball,Susanne Beck,Darius Wlochowitz et al.
Markus Ball et al.
Background: Whole Transcriptome Sequencing (WTS) is a comprehensive alternative to targeted panels for detecting gene fusions and splice variants. To integrate WTS into clinical diagnostics, we compared its performance ag...
Long-term atmospheric exposure to particulate matter and breast cancer risk: findings from a nested case-control study in France [0.03%]
法国嵌套病例对照研究中关于长期大气颗粒物暴露与乳腺癌风险的发现
Delphine Praud,Amina Amadou,Benoît Mercoeur et al.
Delphine Praud et al.
Background: Airborne particulate matter (PM) is a complex mixture of particles thought to be associated with a range of adverse health effects, including female breast cancer. Current evidence on the association between P...