New implications from long-term outcomes of perioperative therapy in resectable pancreatic cancer [0.03%]
可切除型胰腺癌围手术期治疗长期疗效的新启示
Christoph Springfeld,Thilo Hackert,Daniel H Palmer et al.
Christoph Springfeld et al.
The biggest impact on increasing survival for pancreatic cancer has come about by combining surgical resection with systemic chemotherapy. This groundbreaking paradigm has come under increasing scrutiny relating to the choice of adding chem...
Efficacy and safety of garsorasib in patients with KRAS G12C-mutated advanced pancreatic cancer [0.03%]
Garsorasib治疗KRAS G12C突变晚期胰腺癌患者的有效性和安全性
Noboru Yamamoto,Dong Yan,Vinod Ganju et al.
Noboru Yamamoto et al.
Background: Garsorasib (D-1553), a highly selective, oral KRASG12C inhibitor, has shown clinical efficacy in NSCLC and CRC and is under evaluation in pancreatic cancer. ...
The association between lower urinary tract symptoms and urinary tract infections, and subsequent prostate cancer workup: a nationwide population-based case-control study [0.03%]
一项全国范围基于人口的病例对照研究：下尿路症状和尿路感染与后续前列腺癌检查之间的关联
Jeppe Lyngbye Widding,Hein Vincent Stroomberg,Susanne Oksbjerg Dalton et al.
Jeppe Lyngbye Widding et al.
Background: We investigated how lower urinary tract symptoms (LUTS) and urinary tract infections (UTIs) affect prostate-specific antigen (PSA) testing and prostate cancer (PCa) workup. Furthermore, we examined the likelih...
Correction: Preferences for multi-cancer tests (MCTs) in primary care: discrete choice experiments of general practitioners and the general public in England [0.03%]
纠正：英格兰基层医疗中对多癌症筛查(MCTs)的偏好：来自全科医师和普通民众的选择试验
John Buckell,Nomalanga Madyiwa,Gail Hayward et al.
John Buckell et al.
Published Erratum
British journal of cancer. 2025 Dec 1. DOI:10.1038/s41416-025-03213-z 2025
Antigen-specific CD8+CD39+ cytotoxic T cell density in the microenvironment of hepatocellular carcinoma predicts patient survival [0.03%]
肝细胞癌微环境中抗原特异性CD8+CD39+细胞毒性T细胞密度可预测患者预后
Konstantina Dimopoulou,Aris Spathis,Christina Papamichail et al.
Konstantina Dimopoulou et al.
Introduction: Tumour antigen-specific CD8+CD39+ T cells (TSTs) are crucial components of anti-tumour adaptive immunity, which in tumour microenvironment (TME) may be found at various differentiation stages, from early ste...
Impact of concomitant medications on efficacy of CLDN18.2-specific CAR-T cell therapy in advanced gastric cancer [0.03%]
合并用药对胃癌晚期患者CLDN18.2特异性CAR-T细胞治疗疗效的影响
Jiarui Li,Lian Liu,Min Tao et al.
Jiarui Li et al.
Background: Claudin18.2 (CLDN18.2)-specific CAR-T cell therapy has demonstrated promise in advanced gastric cancer (GC). However, the impact of concomitant medications on the efficacy outcomes remains unclear. ...
eIF3i facilitates NELFCD translation to promote metastasis via regulating EMT and invadopodia [0.03%]
eIF3i通过调节上皮间质转化和侵袭小泡促进NELFCD翻译以促进转移
Qing Huang,Juan Zhao,Yang Zhang et al.
Qing Huang et al.
Background: Translational reprogramming enables cancer cells to drive tumour progression and metastasis. eIF3i is a core component of the translational regulatory machinery, but the underlying mechanisms through which it ...
Clinicopathological and prognostic significance of mucin signatures in lower gastrointestinal cancer-a systematic review and meta-analysis [0.03%]
黏蛋白在大肠癌中的临床病理及预后价值：系统综述和meta分析研究
Axel Van Meer,Jacques Gilis,Baptiste Oosterlinck et al.
Axel Van Meer et al.
Aberrant mucin expression is implicated in lower gastrointestinal tract (GIT) cancers, yet its clinicopathological relevance remains poorly understood. To identify distinct mucin signatures in association with (pre)tumour subtypes, anatomic...
Correlation between imaging-detected and pathological extranodal extension in a randomised trial in Human Papillomavirus-positive oropharyngeal cancer [0.03%]
一项关于人乳头瘤病毒阳性口咽癌随机试验中影像学检测和病理学淋巴结外侵的相关性研究
Mererid Evans,Chris Hurt,Rhian Rhys et al.
Mererid Evans et al.
Background: Imaging-detected and pathological extranodal extension (iENE, pENE) negatively impact prognosis in Human Papillomavirus (HPV)-positive oropharyngeal cancer (OPSCC), as reflected in future TNM staging updates. ...
Crosstalk of NPY and TGFβ orchestrates the signaling to facilitate perineural invasion of oral squamous cell carcinoma [0.03%]
神经肽Y和转化生长因子β的相互作用促进口腔鳞癌的周神经系统浸润信号传导
Jing Bi,Ketong Liu,Yiru Luo et al.
Jing Bi et al.
Background: Perineural invasion (PNI) frequently occurs in oral squamous cell carcinoma (OSCC) and predicts poor prognosis. Although PNI is increasingly recognised as a process driven by tumour-nerve crosstalk, the underl...