Patient-centered outcomes according to cancer status in cardiac surgery patients: a population-based cohort study [0.03%]
Habib Jabagi,Joshua G Lee,Osamu W Yasui et al.
Habib Jabagi et al.
Background: More cancer survivors are undergoing cardiac surgery, but their postoperative outcomes remain poorly understood. We aimed to describe the incidence and predictors of postoperative major adverse cardiovascular ...
Addition of zoledronic acid to consolidation chemotherapy in Ewing sarcoma-EURO EWING 2012 (EE2012): an international, open-label, randomised controlled phase III trial [0.03%]
Brennan Bernadette,Laura Kirton,Perrine Marec-Bérard et al.
Brennan Bernadette et al.
Background: Pre-clinical data demonstrated anti-tumour effect in Ewing sarcoma (ES) for zoledronic acid. This provided the rationale for the second randomisation (R2) in the EURO EWING 2012 (EE2012) trial, whether the add...
Genomic sequencing of multicystic mesothelioma finds cohesin complex mutations associated with disease recurrence in patients referred for cytoreductive surgery and HIPEC [0.03%]
Jane Gibson,Norman John Carr,Sophia Stanford et al.
Jane Gibson et al.
Background: Multicystic mesothelioma (MCM) is a rare disease and there is debate about it's neoplastic nature with a spectrum of disease behaviour and little known about the genomic profile. In contrast, the genomic profi...
Shadi Azam,Anjile An,Kevin H Kensler et al.
Shadi Azam et al.
Background: Timely surgical treatment is critical for optimal breast cancer (BC) outcomes, yet delays in care persist. This study examined associations between social drivers of health (SDOH), race/ethnicity, and delayed ...
Investigating PAK inhibition in combination with PD-1 blockade to enhance cytotoxic CD8+ T cell-mediated killing and suppress invasion of ovarian cancer cells [0.03%]
PAK抑制与PD-1阻断联合应用增强细胞毒CD8+t细胞介导的杀伤并抑制卵巢癌细胞浸润的研究
Alexandria R Mitchell,Yiran Chen,Giuseppe Pugliese et al.
Alexandria R Mitchell et al.
Background: P-21 activated kinase (PAK) overexpression, phosphorylation, and gene amplification have been reported to increase cellular invasion in ovarian cancer (ovcan), worsening patient prognoses. One notable method o...
Enhanced nuclear export caused by O-GlcNAcylation of nucleoporins is a potential therapeutic target in mesothelioma [0.03%]
核小体重塑引起的核输出增强是间皮瘤的潜在治疗靶点
Satomi Mukai,Tatsuhiro Sato,Yasuhiro Kamei et al.
Satomi Mukai et al.
Background: Mesothelioma is an aggressive malignancy with limited therapeutic options. Genetic alterations involving the Hippo pathway are commonly observed. O-GlcNAcylation is frequently elevated in cancer and drives tum...
Dynamic reorganisation of intratumoural bacterial florae during colorectal cancer progression [0.03%]
结直肠癌进展期间瘤内细菌菌群的动态再组织
Minghao Li,Yang Li,Chen Li et al.
Minghao Li et al.
Background: Colorectal cancer (CRC) exhibits distinct bacterial community compositions compared to healthy mucosae, which intimately correlate with CRC clinical outcomes. There is a lack of explanation for the inducements...
Impact of oxidative and antioxidative potential on cancer risk: the Japan Public Health Center-based Prospective Study [0.03%]
氧化与抗氧化潜能对癌症风险的影响：基于日本公共健康中心的前瞻性研究
Kenshiro Nishihara,Taiki Yamaji,Yukai Lu et al.
Kenshiro Nishihara et al.
Background: This study aimed to elucidate the impact of systemic shifts towards increased oxidative or antioxidative potential on cancer development and suppression. Given that longitudinal studies on cancer associations ...
"I don't think I even thought of myself" A mixed-methods study of family experiences of trio germline whole genome sequencing in newly diagnosed childhood cancer [0.03%]
“我从未考虑过这个问题——家庭成员参与三联胚系全基因组测序的质性研究：儿童新发肿瘤患者的护理要点
Jacqueline D Hunter,Kate Hetherington,Maeve McGillycuddy et al.
Jacqueline D Hunter et al.
Background: Germline genomic sequencing (GGS) is increasingly offered to children with cancer. We explored families' experiences of consent, result-disclosure, and satisfaction in the PREDICT study, a standalone trio-GGS ...
Inhibition of c-FLIP alongside TRAIL treatment suppresses prostate cancer stem cell activity [0.03%]
c-FLIP与TRAIL联合治疗可抑制前列腺癌干细胞活性
Daniel J Turnham,Rhiannon French,Fiona M Frame et al.
Daniel J Turnham et al.
Background: Prostate cancer is a leading cause of cancer-associated death in men worldwide. Inhibition of the Cellular FLICE-like Inhibitory Protein (cFLIP), which is overexpressed in prostate cancer, alongside TRAIL trea...