Measurable residual disease as an actionable biomarker in acute myeloid leukemia. Ready or not? [0.03%]
微小残留病在急性髓系白血病中的作用——作为生物标志物的微小残留病，我们现在准备好了吗？
Francesco Buccisano,Raffaele Palmieri,Federico Moretti et al.
Francesco Buccisano et al.
Purpose of review: Measurable residual disease (MRD) is a reliable biomarker measuring the quality of morphological complete remission in acute myeloid leukemia (AML). This review will illustrate the settings where, along...
Antoine Seyve,François Ducray
Antoine Seyve
Purpose of review: Vorasidenib has demonstrated efficacy in isocitrate dehydrogenase (IDH)-mutant grade 2 gliomas that do not require immediate oncological treatment. Here, we summarize open questions regarding its long-t...
Monitoring serum estradiol in premenopausal women with hormone receptor-positive breast cancer on adjuvant LHRH agonists [0.03%]
绝经前激素受体阳性乳腺癌患者在辅助治疗LHRH激动剂过程中监测血清雌二醇水平
Carmine Valenza,Julian D Etessami,Elisabetta Munzone et al.
Carmine Valenza et al.
Purpose of review: To review the current evidence and inform clinical guidance on the implications of incomplete ovarian function suppression (OFS), the utility of serum estradiol (E2) monitoring, and appropriate manageme...
Predictors of response to CD19 chimeric antigen receptor T-cell therapy in large B-cell lymphoma: a consolidated review [0.03%]
抗CD19嵌合抗原受体T细胞治疗大B细胞淋巴瘤反应的预测因素：荟萃分析
Ori Ben Valid,Roni Shouval
Ori Ben Valid
Purpose of review: CD19-directed chimeric antigen receptor T-cell (CAR-T) therapy has transformed outcomes for relapsed/refractory large B-cell lymphoma (LBCL), yet nearly half of treated patients relapse, and toxicities ...
Kuo-Kai Chin,Martin S Tallman
Kuo-Kai Chin
Purpose of review: Patients with acute promyelocytic leukemia (APL) who present with leukocytosis are considered high-risk due to lower relapse-free survival when treated with all-trans retinoic acid (ATRA) and anthracycl...
Lorenzo Guidi,Dario Trapani,Giuseppe Curigliano
Lorenzo Guidi
Purpose of review: This review aims to summarize the current clinical evidence and future perspectives on the use of antiandrogen therapies in metastatic breast cancer, focusing on hormone receptor-positive and triple-neg...
Marie Porte,Christophe Massard
Marie Porte
Purpose of review: Brain metastases occur in nearly 20% of all patients with cancer, with a rising incidence in recent years, partly due to improved systemic therapies that have prolonged survival. Traditionally managed w...
Patient-proxy agreement on health-related quality of life assessment in cancer patients [0.03%]
癌症患者与委托人对健康相关生活质量评估的一致性研究
Josien C C Scheepens,Florien W Boele,Johan A F Koekkoek
Josien C C Scheepens
Purpose of review: The aim of this study was to examine the role of proxy-reported outcomes in oncology, particularly in neuro-oncology, where cognitive impairment and disease progression often limit patient' ability to s...
Anupama Krishnamoorthi,Rohit Vijjhalwar,Ananya Kannan et al.
Anupama Krishnamoorthi et al.
Purpose of review: Smoldering myeloma (SMM) is an asymptomatic precursor condition of multiple myeloma (MM) with a prevalence of about 0.5% in those aged >40 years age. While the current standard of care is active surveil...
Alessandro Isidori,Giovanni Marconi
Alessandro Isidori
Purpose of review: Acute myeloid leukemia (AML) characterized by NPM1 mutations or KMT2A rearrangements depends on abnormal epigenetic programs mediated by menin, a critical scaffold protein for sustaining the expression ...