Recent highlights and breakthroughs in immunotherapy for head and neck cancers [0.03%]
头颈癌免疫治疗的新进展和突破性成果
Joanna A Vuille,Petr Szturz
Joanna A Vuille
Purpose of review: This review highlights recent advances in immunotherapy for head and neck oncology, focusing on pivotal studies, both early-stage and late-stage, published or presented in 2025. ...
Circulating tumor DNA in human papilloma virus negative head and neck squamous cell carcinoma [0.03%]
人乳头瘤病毒阴性的头颈鳞癌的循环肿瘤DNA
Rachel Galot,Jean-Pascal Machiels
Rachel Galot
Purpose of review: Human papilloma virus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) remains a challenging disease with poor prognosis. Circulating tumor DNA (ctDNA) has emerged as a promising biomarker t...
Tumor microenvironment-driven immune evasion and therapeutic strategies in head and neck squamous cell carcinoma [0.03%]
肿瘤微环境介导的免疫逃逸和头颈鳞癌治疗策略
Ingeborg Tinhofer,Anne-Sophie Fisch
Ingeborg Tinhofer
Purpose of review: Head and neck squamous cell carcinoma (HNSCC) develops within a complex tumor microenvironment (TME) that fosters immune evasion and limits the efficacy of immune checkpoint inhibitors (ICIs). Despite a...
Circulating Epstein-Barr virus DNA as a precision biomarker in nasopharyngeal carcinoma: from risk stratification to real-time treatment adaptation and disease surveillance [0.03%]
循环EB病毒DNA作为鼻咽癌精准标志物：从风险分层到实时个体化治疗及监测
Emma R Y Zhang,Jia Ling Neo,Melvin L K Chua
Emma R Y Zhang
Purpose of review: Nasopharyngeal carcinoma (NPC) is a virally driven malignancy with marked biological heterogeneity that is inadequately captured by anatomical staging alone. Circulating plasma Epstein-Barr virus (EBV) ...
Ahmed Bilal Khalid,Tareq Salous
Ahmed Bilal Khalid
Purpose of review: Remaining challenges in management of patients with germ cell tumors (GCTs) include selecting the optimal treatment modality in patients with early metastatic disease, biomarker development and developi...
Emerging role of functional imaging in renal cell carcinoma: from morphology to molecular phenotyping with PET/computed tomography [0.03%]
分子影像在肾细胞癌中的新作用：从形态学到PET/CT分子分型
Geetha Guduguntla,Sidney M Levy,Michael S Hofman
Geetha Guduguntla
Purpose of review: Functional imaging in renal cell carcinoma (RCC), particularly in clear-cell (ccRCC), has accelerated over the past decade. Rapidly developing novel radiotracers signal growing clinical reliance for bet...
Targeting poly(ADP-ribose) polymerase in metastatic prostate cancer: current landscape and future directions [0.03%]
靶向聚腺苷二磷酸核糖聚合酶在转移性前列腺癌中的应用：现状与未来方向
Xiaolei Shi,Safiullah Rifai,Zumar Meher et al.
Xiaolei Shi et al.
Purpose of review: PARP inhibitors (PARPi) have rapidly reshaped the treatment landscape for metastatic prostate cancer, moving from biomarker-selected monotherapy in metastatic castration-resistant prostate cancer (mCRPC...
Circulating tumor DNA for human papilloma virus-positive disease: ready for prime time? [0.03%]
人乳头瘤病毒阳性疾病的循环肿瘤DNA检测：准备就绪了吗？
Émilie C M de Groot,C René Leemans,Ruud H Brakenhoff
Émilie C M de Groot
Purpose of review: Oropharyngeal squamous cell carcinomas (OPSCC) are caused by human papillomavirus (HPV) infection with increasing frequencies. HPV-positive OPSCC is often treated by definitive radiotherapy or chemoradi...
Understanding financial toxicity in cancer care through a social-ecological lens [0.03%]
从社会生态学角度理解癌症治疗中的财务困境
Joshua A Budhu,Bridgette Thom,Fumiko Chino
Joshua A Budhu
Purpose of review: Financial toxicity, defined as the material hardship and psychological distress associated with the costs of cancer care, has become a central concern in oncology as treatment complexity and patient cos...
Henry C Y Wong,Nicolas H Hart,Alexandre Chan et al.
Henry C Y Wong et al.
Purpose of review: Cancer survivorship is increasingly recognized as an important component of cancer care, yet access to high-quality care remains inconsistent globally. This review highlights priorities for advancing su...