Jennifer A DeSimone,Pooja Sodha,Desislava Ignatova et al.
Jennifer A DeSimone et al.
Purpose of review: Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of skin-homing T-cell neoplasms, which represent approximately 75% of all primary cutaneous lymphomas. Currently available drug therapies, when ...
Belinda Lee,Shahneen Sandhu,Grant McArthur
Belinda Lee
Purpose of review: This review highlights recent clinical developments in the therapeutic targeting of cell cycle control in melanoma with cyclin-dependent kinase inhibitors, checkpoint kinases, MDM2, MDM4 and p53 inhibit...
Georg Pall
Georg Pall
Purpose of review: Crizotinib now is accepted as the standard first-line treatment of ALK-rearranged lung adenocarcinomas. To overcome the problem of crizotinib resistance, second-generation ALK inhibitors are in developm...
Eva Faurobert,Anne-Pascale Bouin,Corinne Albiges-Rizo
Eva Faurobert
Purpose of review: Much effort has been devoted to determining how cellular and noncellular components of the tumoral niche initiate and promote cancer development. Cancer cells perceive biochemical signals from component...
Selma Masri,Kenichiro Kinouchi,Paolo Sassone-Corsi
Selma Masri
Purpose of review: The interplay between circadian rhythm and cancer has been suggested for more than a decade based on the observations that shift work and cancer incidence are linked. Accumulating evidence implicates th...
Gain-of-function mutation of chromatin regulators as a tumorigenic mechanism and an opportunity for therapeutic intervention [0.03%]
染色质调节因子的增效功能突变作为一种致癌机制及治疗机会
Chen Shen,Christopher R Vakoc
Chen Shen
Purpose of review: Somatic gain-of-function mutations that drive cancer pathogenesis are well established opportunities for therapeutic intervention, as demonstrated by the clinical efficacy of kinase inhibitors in kinase...
Gerd P Pfeifer
Gerd P Pfeifer
Purpose of review: The mutational patterns of cancer genomes allow conclusions or generation of hypotheses as to what mechanisms or environmental, dietary or occupational exposures might have created the mutations and the...
Salem I Noureldine,Ralph P Tufano
Salem I Noureldine
Purpose of review: The association of Hashimoto's thyroiditis and thyroid cancer remains an active focus of research and controversy. Since it was first proposed in 1955, numerous studies have explored the epidemiology an...
Thyroglobulin antibody status and differentiated thyroid cancer: what does it mean for prognosis and surveillance? [0.03%]
甲状腺球蛋白抗体状态与分化型甲状腺癌：这对预后和随访意味着什么？
Andrew G Gianoukakis
Andrew G Gianoukakis
Purpose of review: To provide an overview of the clinical utility of thyroglobulin antibody (TgAb) measurements in the management of differentiated thyroid cancer (DTC), taking into consideration the methodological concer...
What is the appropriate role of minimally invasive vs. open surgery for small adrenocortical cancers? [0.03%]
微创手术与开放手术在小肾上腺皮质癌中的作用哪个更合适？
Rocco Bellantone,Celestino P Lombardi,Marco Raffaelli
Rocco Bellantone
Purpose of review: The role of endoscopic adrenalectomy for adrenocortical carcinoma is the most controversial and debated points in adrenal surgery. We reviewed the most recent literature on this topic. ...