Isolation of genes controlling apoptosis through their effects on cell survival [0.03%]
通过细胞存活效应控制凋亡的基因分离
Gwyn T Williams,Jane P Hughes,Victoria Stoneman et al.
Gwyn T Williams et al.
The identification of the most suitable molecular targets for gene and drug therapy is the crucial first step in the development of new disease treatments. The rational identification of such targets depends on a detailed understanding of t...
Visualization of transfer of a fluorescently-labeled membrane raft protein to T cells using lentivirus [0.03%]
利用 Lentiviral 将荧光标记的膜筏蛋白转移并展示在T细胞上的可视化研究
Jennifer Byrum,William Rodgers
Jennifer Byrum
Lentivirus vector systems have been developed for the safe delivery of foreign genes to target tissues. However, the use of these systems for delivering specific proteins to target cells has been largely unexplored. To test this concept, th...
Mechanisms of malignant glioma immune resistance and sources of immunosuppression [0.03%]
恶性胶质瘤免疫抵抗机制及免疫抑制来源
German G Gomez,Carol A Kruse
German G Gomez
High grade malignant gliomas are genetically unstable, heterogeneous and highly infiltrative; all characteristics that lend glioma cells superior advantages in resisting conventional therapies. Unfortunately, the median survival time for pa...
An Erythroid-Specific Chromatin Opening Element Increases β-Globin Gene Expression from Integrated Retroviral Gene Transfer Vectors [0.03%]
一个红细胞特异的染色体开放元件能够增加整合型逆转录病毒载体中的β-珠蛋白基因表达
Michael J Nemeth,Christopher H Lowrey
Michael J Nemeth
Gene therapy strategies requiring long-term high-level expression from integrated genes are currently limited by inconsistent levels of expression. This may be observed as variegated, silenced or position-dependent gene expression. Each of ...
Catalytic nucleic acid enzymes for the study and development of therapies in the central nervous system: Review Article [0.03%]
用于中枢神经系统研究和治疗开发的催化性核酸酶：综述文章
Richard Tritz,Cellia Habita,Joan M Robbins et al.
Richard Tritz et al.
Nucleic acid enzymes have been used with great success for studying natural processes in the central nervous system (CNS). We first provide information on the structural and enzymatic differences of various ribozymes and DNAzymes. We then d...