Adenoviral-delivered HE4-HSV-tk sensitizes ovarian cancer cells to ganciclovir [0.03%]
腺病毒传递的HE4-HSV-tk使卵巢癌细胞对更昔洛韦敏感
Jennifer W Rawlinson,Kiara Vaden,Joseph Hunsaker et al.
Jennifer W Rawlinson et al.
Ovarian cancer (OC) is most often contained within the peritoneal cavity, making it an ideal disease for adenoviral-delivered gene therapies. In effort to develop a safe and effective gene therapy for OC, we created a replication deficient ...
Towards understanding the epigenetics of transcription by chromatin structure and the nuclear matrix [0.03%]
由染色质结构和核基质介导的转录表观遗传学研究进展
Rui Pires Martins,Stephen A Krawetz
Rui Pires Martins
The eukaryotic nucleus houses a significant amount of information that is carefully ordered to ensure that genes can be transcribed as needed throughout development and differentiation. The genome is partitioned into regions containing func...
Maintenance of a functional higher order chromatin structure: The role of the nuclear matrix in normal and disease states [0.03%]
功能性高级染色体结构的维持：核基质在正常和疾病状态下的作用
Amelia K Linnemann,Stephen A Krawetz
Amelia K Linnemann
The ordered packaging of DNA within the nucleus of somatic cells reflects a dynamic supportive structure that facilitates stable transcription interrupted by intermittent cycles of extreme condensation. This dynamic mode of packing and unpa...
Decreased risk of bladder cancer in men treated with quinazoline-based α1-adrenoceptor antagonists [0.03%]
喹唑啉类α1-肾上腺素受体拮抗剂治疗减少男性膀胱癌风险
Frances M Martin,Andrew M Harris,Randall G Rowland et al.
Frances M Martin et al.
Previous studies documented that human bladder cancer cells are sensitive to the apoptotic effects of quinazoline-derived α1-adrenoreceptor antagonists and bladder tumors exhibit reduced tissue vascularity in response to terazosin. More re...
Inhibition of caspase-3 by Survivin prevents Wee1 Kinase degradation and promotes cell survival by maintaining phosphorylation of p34Cdc2 [0.03%]
Survivin通过防止Weel激酶降解来抑制caspase-3,从而维持p34cdc2的磷酸化并促进细胞生存
Javier Rivera Guzman,Seiji Fukuda,Louis M Pelus
Javier Rivera Guzman
The anti-apoptotic protein Survivin and the cyclin-dependent kinase p34Cdc2 regulate cell cycle progression and apoptosis. p34Cdc2 activation is required for its pro-apoptotic activity and phosphorylation of p34Cdc2 at Tyrosine-15 (Tyr15) m...
Binoj Chandrasekharan Nair,Ratna K Vadlamudi
Binoj Chandrasekharan Nair
Estrogen Receptor (ER) plays a central role in the development and progression of breast cancer. Hormonal therapy substantially improves disease-free survival of ER+ve breast tumors, however acquired resistance to endocrine therapies freque...
Curcumin is not a ligand for peroxisome proliferator-activated receptor-γ [0.03%]
姜黄素不是过氧化物酶体增殖激活受体γ的配体
Venkata R Narala,Monica R Smith,Ravi K Adapala et al.
Venkata R Narala et al.
Curcumin, a compound found in the spice turmeric, has been shown to possess a number of beneficial biological activities exerted through a variety of different mechanisms. Some curcumin effects have been reported to involve activation of th...
Arash Hatefi,Brenda F Canine
Arash Hatefi
Gene therapy is perceived as a revolutionary technology with the promise to cure almost any disease, provided that we understand its genetic basis. However, enthusiasm has rapidly abated as multiple clinical trials have failed to show effic...
Immunoresistant human glioma cell clones selected with alloreactive cytotoxic T lymphocytes: downregulation of multiple proapoptotic factors [0.03%]
人胶质瘤细胞克隆的免疫抗性选择：多种促凋亡因子下调
German G Gomez,Michelle J Hickey,Richard Tritz et al.
German G Gomez et al.
We previously reported the cellular, functional and cytogenetic characterization of immunoresistant (IR) 13-06-IR29 and 13-06-IR30 human glioma cell clones isolated after immunoselection with alloreactive cytotoxic T lymphocytes (aCTL). Rel...
Adam M Sonabend,Ilya V Ulasov,Maciej S Lesniak
Adam M Sonabend
High-grade gliomas remain relatively resistant to current therapy. Local recurrence is a common feature and the majority of patients progress despite conventional therapy. One modality-gene therapy-has shown a lot of promise in early precli...