Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management [0.03%]
重访毛囊免疫豁免： alopecia areata治疗的关键
Ralf Paus,Silvia Bulfone-Paus,Marta Bertolini
Ralf Paus
The collapse of the immune privilege (IP) of the anagen hair bulb is now accepted as a key element in AA pathogenesis, and hair bulb IP restoration lies at the core of AA therapy. Here, we briefly review the essentials of hair bulb IP and r...
David A Norris
David A Norris
During its 25th anniversary year, the National Alopecia Areata Foundation (NAAF) undertook a project to completely re-evaluate their research program and to help focus and direct future directions of alopecia areata (AA) research to better ...
Prostaglandin D2 Uses Components of ROS Signaling to Enhance Testosterone Production in Keratinocytes [0.03%]
前列腺素D2使用ROS信号传导组件以增强角质细胞内睾丸酮的生成
Alon Mantel,J Tyson McDonald,Kennedy Goldsborough et al.
Alon Mantel et al.
Elevated levels of prostaglandin D2 (PGD2) have been shown to be present in the bald scalp of androgenic alopecia (AGA) patients and to functionally inhibit hair growth. However, its precise mechanism in AGA has yet to be clearly defined. A...
Animesh A Sinha,Rama Dey-Rao
Animesh A Sinha
Lupus erythematosus is a chronic autoimmune disorder with a protean clinical manifestation affecting virtually every organ including skin, with tremendous variation between patients. This makes it vital to stratify patients on a molecular b...
Not Just Skin Deep: Systemic Disease Involvement in Patients With Cutaneous Lupus [0.03%]
狼疮性皮炎患者的全身性疾病并发症不容忽视
Jack C O&#x;Brien,Benjamin F Chong
Jack C O&#x;Brien
Cutaneous lupus erythematosus, specifically discoid lupus erythematosus, disproportionately affects those with skin of color and may result in greater dyspigmentation and scarring in darker skin types. In this article, we review investigati...
Fnu Nutan,Alex G Ortega-Loayza
Fnu Nutan
Systemic lupus erythematosus is a chronic inflammatory condition which affects predominantly women in their 30s. It has several clinical manifestations, including skin lesions that can be classified as acute cutaneous lupus erythematosus, s...
Quinacrine Suppresses Tumor Necrosis Factor-α and IFN-α in Dermatomyositis and Cutaneous Lupus Erythematosus [0.03%]
羟氯喹通过抑制肿瘤坏死因子和I型干扰素治疗皮肌炎和狼疮疹
Paul Alves,Muhammad M Bashir,Maria Wysocka et al.
Paul Alves et al.
Antimalarials are used to treat dermatomyositis (DM) and cutaneous lupus erythematosus (CLE). Although hydroxychloroquine (HCQ) is frequently used, addition of quinacrine (QC) has shown additional clinical effects when combined with HCQ. To...
Central Centrifugal Cicatricial Alopecia: New Insights and a Call for Action [0.03%]
中央中心性疤痕性斑秃：新见解与行动呼吁
Ncoza C Dlova,Kimberly S Salkey,Valerie D Callender et al.
Ncoza C Dlova et al.
Central centrifugal cicatricial alopecia (CCCA) is a common and progressive form of lymphocyte predominant scarring alopecia which impacts negatively on the quality of life of those affected. It is seen more commonly in women of African des...
Donald A Glass nd
Donald A Glass nd
Keloids are an exuberant response to cutaneous wound healing. Several lines of evidence suggest that keloid scarring is influenced by genetic factors. This review will discuss our current understanding of genetic influences on keloidal scar...
Abby S Van Voorhees,Clinton W Enos
Abby S Van Voorhees
Given the change in our population to one that is more racially and ethnically diverse, the topic of diversity in dermatology residency programs has gained attention. In a field that has become highly competitive, diversity is lagging behin...