Genetic Profiles for Systemic Lupus Erythematosus in Han Chinese Population: From Genome-Wide Association Study to Exome-Wide Association Study [0.03%]
汉族人群系统性红斑狼疮的遗传特征：从全基因组关联研究到外显子组广义关联研究
Leilei Wen,Lu Liu,Ke Xue et al.
Leilei Wen et al.
Systemic lupus erythematosus (SLE) is a chronic heterogeneous autoimmune disease characterized by loss of tolerance to self-antigens, complement activation, dysregulated type 1 IFN responses, and immune-mediated tissue damage. The clinical ...
Is the Nervous System More Important Than the Immune System in Itch and Atopic Dermatitis? [0.03%]
神经系统的痒和特应性皮炎作用较免疫系统更重要吗？
Ethan A Lerner
Ethan A Lerner
Atopic dermatitis is a common cutaneous disorder characterized by severe itch, chronic inflammation, and increased nerve fiber density. It has been assumed that the neural changes are in response to ongoing inflammation. We used in vivo ima...
Cong Peng,Xiang Chen
Cong Peng
CD147, also named as BSG, was first identified from F9 embryonal carcinoma cells (Miyauchi et al., 1990) and the human BSG locus on chromosome 19p13.3 containing 10 exons (Belton et al., 2008; Kaname et al., 1993; Liao et al., 2011), which ...
Jun Li,Jun Xie,Jintao Zhu et al.
Jun Li et al.
Malignant melanoma is the most aggressive and lethal form of skin cancer with an increasing incidence worldwide. In the past 5 years, the Food and Drug Administration has approved six targeted therapies or immunotherapies for the treatment ...
How Bad Is the Hedgehog? GLI-Dependent, Hedgehog-Independent Cancers on the Importance of Biomarkers for Proper Patients Selection [0.03%]
刺猬到底有多坏？GLI依赖性、刺猬非独立癌症在生物标志物选择恰当病人中的重要性
Delphine Javelaud,Aurélien De Reyniès,Alain Mauviel
Delphine Javelaud
Hedgehog (HH) signaling plays an important role both during embryonic development and adult life. It is involved in the regulation of cell differentiation, cell proliferation and tissue polarity, as well as in the maintenance of stem cells,...
Carola Berking
Carola Berking
In recent years, the treatment of advanced melanoma has been revolutionized by the introduction of new innovative approaches, namely mutation-based targeted therapy and immune checkpoint blockade by CTLA4 and PD-1/PD-L1 inhibitors. The deca...
Investigation of Psoriasis Susceptibility Loci in Psoriatic Arthritis and a Generalized Pustular Psoriasis Cohort [0.03%]
银屑病易感基因位点在银屑病关节炎及泛发性脓疱型银屑病中的研究
Zheng Zhang,Jin-Hua Xu
Zheng Zhang
Psoriasis is a common skin disease affecting 1-3% of the population (Gelfand et al., 2005; Ferrándiz et al., 2001). Approximately 30% of patients with psoriasis develop psoriatic arthritis (PsA), an inflammatory arthritis associated with p...
Ming Zhao,Qianjin Lu
Ming Zhao
Psoriasis is a chronic and recurrent inflammatory skin disease that is characterized by abnormal keratinocyte proliferation, vascular hyperplasia, and infiltration of inflammatory cells into the dermis and epidermis. It is generally accepte...
Fusheng Zhou,Xuejun Zhang
Fusheng Zhou
Major histocompatibility complex (MHC), also known as human leukocyte antigen (HLA) in humans, is one of the most genetically diverse regions in the genome of various species. The human MHC contains about 400 genes in a ∼7.6-Mb span locate...
Expanded Genome-Wide Association Study Meta-Analysis of Psoriasis Expands the Catalog of Common Psoriasis-Associated Variants [0.03%]
扩展的全基因组关联研究荟萃分析扩展了常见银屑病相关变异目录
James T Elder
James T Elder
Psoriasis is a complex immune-mediated disease of skin and joints with a prevalence of about 2%. Previous genetic association studies have identified more than 60 psoriasis susceptibility loci, 47 of which were identified in Caucasians. To ...