Hind M Almohanna,Azhar A Ahmed,Jacob W Griggs et al.
Hind M Almohanna et al.
Platelet-rich plasma (PRP) is an autologous preparation of plasma with concentrated platelets containing various growth factors and cytokines that enhance the body's inherent capacity to repair and regenerate hair follicles. A few studies a...
Brigham Eyebrow Tool for Alopecia: A Reliable Assessment of Eyebrow Alopecia Areata [0.03%]
用于脱发性 eyebrow 疾病的 Brigham 眉毛工具：对眉毛斑秃进行可靠评估
Elizabeth Tkachenko,Kathie P Huang,Justin M Ko et al.
Elizabeth Tkachenko et al.
There are no tools to evaluate eyebrow involvement in patients with alopecia areata. We developed and assessed the reliability of the Brigham Eyebrow Tool for Alopecia (BETA) as a quantitative evaluation of eyebrow alopecia areata. BETA use...
Lucy Y Liu,Brett A King,Justin M Ko
Lucy Y Liu
Alopecia areata affects not only scalp hair but also other sites of body hair, including eyebrows. Our objective was to investigate the importance of eyebrows in the treatment goals of patients with alopecia areata. Through an online questi...
JAK Inhibitors for the Treatment of Pediatric Alopecia Areata [0.03%]
JAK抑制剂在儿童 alopecia areata治疗中的应用
Claire E Hamilton,Brittany G Craiglow
Claire E Hamilton
Alopecia areata is a common autoimmune condition that disproportionately affects children and can significantly hinder quality of life. Few safe and effective therapies are available for the treatment of severely affected pediatric patients...
Maria K Hordinsky
Maria K Hordinsky
The number of alopecia areata (AA) clinical trials with Jak inhibitors of cytoplasmic tyrosine kinases, including Jak1, Jak2, Jak3, and tyrosine-protein kinase has increased significantly since the last Research Summit. This fact means that...
Lynn Petukhova
Lynn Petukhova
Human genetic studies of diseases that are multifactorial and prevalent have generated a wealth of knowledge about the genetic architecture of chronic diseases. Generalizable attributes are shaping the development of models to explain how t...
Myeloid Adherent Cells Are Involved in Hair Loss in the Alopecia Areata Mouse Model [0.03%]
髓系粘附细胞参与了斑秃小鼠模型的脱发过程
Yunyuan Li,Ruhangiz T Kilani,Gigi Leung et al.
Yunyuan Li et al.
Alopecia areata (AA), which is defined as an autoimmune hair loss disease, has a serious impact on the quality of life for patients with AA worldwide. In this study, to our knowledge, a previously unreported method of AA induction in C3H mi...
Mouse Models of Alopecia Areata: C3H/HeJ Mice Versus the Humanized AA Mouse Model [0.03%]
斑秃的小鼠模型：C3H / HeJ小鼠与人源化斑秃小鼠模型
Amos Gilhar,Rimma Laufer Britva,Aviad Keren et al.
Amos Gilhar et al.
The C3H/HeJ model has long dominated basic alopecia areata (AA) in vivo research and has been used as proof-of-principle that Jak inhibitors are suitable agents for AA management in vivo. However, its histologic features are not typical of ...
Forging the Future: 2018 Alopecia Areata Research Summit Summary Report [0.03%]
锻造未来：2018年斑秃研究峰会总结报告
Abby Ellison,Dory Kranz,Natasha A Mesinkovska et al.
Abby Ellison et al.
Alopecia areata (AA) is a common autoimmune skin disease resulting in the loss of hair on the scalp and elsewhere on the body that affects over 146 million people worldwide at some point in their lives. Founded in 1981, the National AA Foun...
Functional and Mechanistic Insights into the Pathogenesis of P63-Associated Disorders [0.03%]
P63相关疾病发病机制的功能和机制洞察
Maria Rosaria Mollo,Luisa Cirillo,Claudia Russo et al.
Maria Rosaria Mollo et al.
The p53 family member p63 is a master regulator of gene expression in stratified epithelia, such as the epidermis. One of the main functions of p63 is to sustain mechanical resistance, positively regulating several epidermal genes involved ...