Regulation of skin pigmentation and thickness by Dickkopf 1 (DKK1) [0.03%]
Dickkopf 1(DKK1)调节皮肤色素沉着和厚度
Yuji Yamaguchi,Akimichi Morita,Akira Maeda et al.
Yuji Yamaguchi et al.
Dickkopf 1 (DKK1), an inhibitor of Wnt signaling, not only functions as a head inducer during development, but also regulates joint remodeling and bone formation, which suggests roles for DKK1 in the pathogenesis of rheumatoid arthritis and...
The pathogenesis of photoaging: the role of neutrophils and neutrophil-derived enzymes [0.03%]
光老化发病机制：中性粒细胞及中性粒细胞衍生物酶的作用
Feiko Rijken,Piet L B Bruijnzeel
Feiko Rijken
The hallmark of photoaged skin is solar elastosis, which is probably an end product of elastic fiber degradation. Exposure of human skin to a certain threshold of UV, infrared radiation (IR), and heat leads to an influx of neutrophils. Thes...
Thomas Schwarz,Agatha Schwarz
Thomas Schwarz
As sunscreens do not provide complete protection against solar/UV radiation, alternative protective strategies are necessary to cope with the increasing incidence of skin cancer. These strategies include the reduction of UVR-induced DNA dam...
Involvement of a forkhead transcription factor, FOXO1A, in UV-induced changes of collagen metabolism [0.03%]
UV通过FOXO1A转录因子影响胶原代谢的机制研究
Hiroshi Tanaka,Yuhko Murakami,Izumi Ishii et al.
Hiroshi Tanaka et al.
Transcription factors belonging to the forkhead box gene, group O (FOXOs) family have been found to be crucial in downstream suppression of life-shortening effects of the insulin/insulin-like growth factor-1 (IGF-1) signaling pathway, which...
Non-sunscreen photoprotection: antioxidants add value to a sunscreen [0.03%]
防晒霜的补充光防护措施：抗氧化剂可增加防晒霜的价值
Mary S Matsui,Andrew Hsia,Janine D Miller et al.
Mary S Matsui et al.
The association between ultraviolet radiation (UVR) exposure and both skin cancer and photo-aging is well documented. In addition to the conventional organic-chemical and physical-mineral type sunscreens, other non-sunscreen protective stra...
Akimichi Morita,Kan Torii,Akira Maeda et al.
Akimichi Morita et al.
Although it is now widely recognized that tobacco smoke has negative effects on the skin, the molecular mechanisms underlying its skin-aging effects remain uncertain. Epidemiological studies indicate that tobacco smoking is a strong indepen...
Reactive oxygen species in HaCaT keratinocytes after UVB irradiation are triggered by intracellular Ca(2+) levels [0.03%]
UVB照射后HaCaT角质形成细胞内活性氧的产生与胞内钙离子水平相关
Hitoshi Masaki,Yukiko Izutsu,Shoichi Yahagi et al.
Hitoshi Masaki et al.
It is recognized that reactive oxygen species (ROS) are responsible for skin damage due to UVB-radiation (UVB-R). However, the triggering substance(s) for ROS generation after UVB-R is uncertain with respect to the activation of NADPH oxida...
Role of mitochondria in photoaging of human skin: the defective powerhouse model [0.03%]
线粒体在皮肤光老化中的作用：“功能衰竭假说”
Jean Krutmann,Peter Schroeder
Jean Krutmann
The exact pathogenesis of photoaging of the skin is not yet known. Earlier, a number of molecular pathways explaining one or more characteristics of photoaged skin have been described, but a unifying mechanistic concept is still missing. He...
Mechanism of UVB-induced wrinkling of the skin: paracrine cytokine linkage between keratinocytes and fibroblasts leading to the stimulation of elastase [0.03%]
UVB引起皮肤皱纹的机制：角质细胞和成纤维细胞之间的旁分泌细胞因子链锁刺激弹性蛋白酶生成
Genji Imokawa
Genji Imokawa
In clinical studies, the formation of facial wrinkles has been closely linked to the loss of elastic properties of the skin. Repetitive irradiation of animal skin with UVB radiation at suberythemal doses significantly reduces its elastic pr...
Short- and long-term effects of UV radiation on the pigmentation of human skin [0.03%]
紫外线对人类皮肤色素的短期和长期影响
Sergio G Coelho,Wonseon Choi,Michaela Brenner et al.
Sergio G Coelho et al.
The incidence of skin cancer, including cutaneous melanoma, has risen substantially in recent years, and epidemiological and laboratory studies show that UV radiation is a major causative factor of this increase. UV damage also underlies ph...