Introduction to innovations in the immunology and clinical science of alopecia areata [0.03%]
脱发性斑块的免疫学和临床科学创新综述
Victoria D Kalabokes,Wilma F Bergfeld,Angela M Christiano
Victoria D Kalabokes
Alopecia areata is an autoimmune skin disease resulting in the loss of hair on the scalp and elsewhere on the body. The disease most often occurs in childhood and affects males and females of all ages. The National Alopecia Areata Foundatio...
Neurovascular and neuroimmune aspects in the pathophysiology of rosacea [0.03%]
神经血管和神经免疫学在 rosacea 病理生理中的作用
Verena D Schwab,Mathias Sulk,Stephan Seeliger et al.
Verena D Schwab et al.
Rosacea is a common skin disease with a high impact on quality of life. Characterized by erythema, edema, burning pain, immune infiltration, and facial skin fibrosis, rosacea has all the characteristics of neurogenic inflammation, a conditi...
The role of chronic inflammation in cutaneous fibrosis: fibroblast growth factor receptor deficiency in keratinocytes as an example [0.03%]
慢性炎症在皮肤纤维化中的作用——以角质细胞中成纤维细胞生长因子受体缺乏为例
Michael Meyer,Anna-Katharina Müller,Jingxuan Yang et al.
Michael Meyer et al.
Fibrosis is associated with a variety of skin diseases and causes severe aesthetic and functional impairments. Functional studies in rodents, together with clinical observations, strongly suggest a crucial role of chronic injury and inflamm...
Peter Arne Gerber,Bettina Alexandra Buhren,Martin Steinhoff et al.
Peter Arne Gerber et al.
Rosacea is one of the most common dermatoses of adults. Recent studies have improved our understanding of the pathophysiology of rosacea. Current concepts suggest that known clinical trigger factors of rosacea such as UV radiation, heat, co...
Aisah A Aubdool,Susan D Brain
Aisah A Aubdool
Neurogenic inflammation is involved in skin inflammation. It is hypothesized that it is involved in the pathogenesis of the common chronic cutaneous vascular disorder rosacea, but the exact mechanism of action is currently unknown. Transien...
Reto Huggenberger,Michael Detmar
Reto Huggenberger
The blood and lymphatic vasculature have an important role in skin homeostasis. Angiogenesis and lymphangiogenesis-the growth of new vessels from existing ones-have received tremendous interest because of their role in promoting cancer spre...
Ulf Meyer-Hoffert,Jens-Michael Schröder
Ulf Meyer-Hoffert
A number of different proteases and their inhibitors have a role in skin physiology and in the pathophysiology of inflammatory skin diseases. Proteases are important in the desquamation process and orderly regulation of the skin's barrier f...
Rosacea as a disease of cathelicidins and skin innate immunity [0.03%]
Cathelicidins和皮肤先天免疫在玫瑰痤疮发病机制中的作用
Kenshi Yamasaki,Richard L Gallo
Kenshi Yamasaki
Rosacea is a common and chronic inflammatory skin disease most frequently seen in groups of genetically related individuals. Although the symptoms of rosacea are heterogeneous, they are all related by the presence of characteristic facial o...
Clinical, cellular, and molecular aspects in the pathophysiology of rosacea [0.03%]
玫瑰痤疮的临床、细胞和分子病理生理学方面
Martin Steinhoff,Jörg Buddenkotte,Jerome Aubert et al.
Martin Steinhoff et al.
Rosacea is a chronic inflammatory skin disease of unknown etiology. Although described centuries ago, the pathophysiology of this disease is still poorly understood. Epidemiological studies indicate a genetic component, but a rosacea gene h...
Martin Steinhoff,Paul R Bergstresser
Martin Steinhoff