Pharmacogenomics in clinical drug development and potential for alopecia areata [0.03%]
药物基因组学在临床药物开发中的应用及对斑秃的潜在影响
Amelia W Warner
Amelia W Warner
Alopecia areata, alopecia totalis, and alopecia universalis likely represent a constellation of related diseases with similar, yet distinct heritability markers. There is currently no known curative therapy that works universally for all pa...
Amos Gilhar,Aviad Keren,Ralf Paus
Amos Gilhar
Although alopecia areata (AA) is not life threatening, it may lead to severe psychological disturbances, reducing the quality of life in all ages. Thus, a new animal model is needed for shedding more light onto the pathogenesis of this cell...
James T Elder
James T Elder
Previous genetic epidemiological studies of psoriasis and alopecia areata demonstrated strong heritability in first-degree relatives and in twins. In recent years, these two conditions have emerged as two skin diseases that are starting to ...
Toward T cell protein-protein interaction activity relevant to alopecia areata [0.03%]
与斑秃相关的T细胞蛋白质相互作用活性的研究
Steven C Neier,Stephen E P Smith,Tessa R Davis et al.
Steven C Neier et al.
Development of better therapies for the T cell-mediated autoimmune disease alopecia areata (AA) could be expedited by an improved understanding of the immunologic signals underlying its pathogenesis. To approach this, our group is mounting ...
The biology of IL-15: implications for cancer therapy and the treatment of autoimmune disorders [0.03%]
IL-15的生物学作用：对癌症治疗和自身免疫性疾病治疗的意义
Thomas A Waldmann
Thomas A Waldmann
IL-15 has a pivotal role in life and death of natural killer (NK) and CD8 memory T cells. IL-15 signals through a heterotrimeric receptor involving the common gamma chain (γc) shared with IL-2, IL-4, IL-7, IL-9, and IL-21, IL-2/IL-15 recep...
The role of hair follicle immune privilege collapse in alopecia areata: status and perspectives [0.03%]
斑秃中毛囊免疫豁免破坏的作用：现状与展望
Ralf Paus,Marta Bertolini
Ralf Paus
Alopecia areata (AA) may represent a CD8+T cell-mediated, organ-specific autoimmune disease in which as yet elusive autoantigens are recognized, once they become exposed by ectopic major histocompatibility complex class I expression by anag...
John P Sundberg,Annerose Berndt,Kathleen A Silva et al.
John P Sundberg et al.
Alopecia areata (AA) is a cell-mediated autoimmune disease that targets actively growing hair follicles in mammals, including humans and mice. Development of the C3H/HeJ spontaneous mouse model AA nearly 20 years ago provided a much needed ...
Lynn Petukhova,Angela M Christiano
Lynn Petukhova
A major impetus to initiating the Human Genome Project was the belief that information encoded in the human genome would "accelerate progress in understanding disease pathogenesis and in developing new approaches to diagnosis, treatment, an...
Overview of alopecia areata [0.03%]
斑秃概述
Maria K Hordinsky
Maria K Hordinsky
Alopecia areata is a complex genetic, immune-mediated disease that targets anagen hair follicles. The disease affects children and adults and is characterized by round or oval patches of hair loss, loss of all scalp hair (alopecia totalis),...