Using Microfluidics to Decouple Nucleation and Growth of Protein Crystals [0.03%]
利用微流控技术分离蛋白质晶体成核和生长过程
Jung-Uk Shim,Galder Cristobal,Darren R Link et al.
Jung-Uk Shim et al.
A high throughput, low volume microfluidic device has been designed to decouple the physical processes of protein crystal nucleation and growth. This device, called the Phase Chip, is constructed out of poly(dimethylsiloxane) (PDMS) elastom...
Selection of Protein Crystal Forms Facilitated by Polymer-Induced Heteronucleation [0.03%]
多聚物诱导杂核化促进蛋白晶体形式的选择
Adam L Grzesiak,Adam J Matzger
Adam L Grzesiak
Crystallization of biological macromolecules as high quality single crystals is critical for determining their structure and facilitates the rational design of drugs. Because macromolecules often crystallize in multiple phases that have uni...
Synthesis of Fluorapatite Nanorods and Nanowires by Direct Precipitation from Solution [0.03%]
溶液中直接沉淀合成氟磷灰石纳米棒和纳米线
Haifeng Chen,Kai Sun,Zhiyong Tang et al.
Haifeng Chen et al.
In natural tooth enamel fluoride is always present in the carbonated hydroxyapatite mineral and plays a key role in the prevention of tooth decay. In this study we aimed at mimicking this natural anti-caries ability of the tooth by developi...
Nate Schultheiss,Ann Newman
Nate Schultheiss
This review article will highlight and discuss the advances made over the last 10 years pertaining to physical and chemical property improvements through pharmaceutical cocrystals and, hopefully, draw closer the fields of crystal engineerin...
William W Porter rd,Sophia C Elie,Adam J Matzger
William W Porter rd
Cocrystals of carbamazepine with nicotinamide and saccharin are shown to be polymorphic. Two polymorphs of carbamazepine-nicotinamide (CBZ-NCT) cocrystals and two polymorphs of carbamazepine-saccharin (CBZ-SAC) cocrystals were grown from so...
Investigation of a Privileged Polymorphic Motif: a Dimeric ROY Derivative [0.03%]
一种特权多形性基序的探究：一种二聚体ROY衍生物的研究
Katie M Lutker,Zachary P Tolstyka,Adam J Matzger
Katie M Lutker
Bis(5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrilyl)acetylene, a derivative of the highly polymorphic compound 5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile (ROY) that possesses two chromophores electronically coupled...
Synthesis of Amine-stabilized Aqueous Colloidal Iron Oxide Nanoparticles [0.03%]
胺稳定的水溶性铁 oxide 纳米颗粒的合成研究进展
M Aslam,Elise A Schultz,Sun Tao et al.
M Aslam et al.
We demonstrate a simple one-step process for the synthesis of iron oxide nanoparticle aqueous colloids using the multifunctional molecule, dodecylamine (DDA), that electrostatically complexes with aqueous iron ions (one precursor Fe(2+) fro...
LCP-FRAP Assay for Pre-Screening Membrane Proteins for in Meso Crystallization [0.03%]
用于介观结晶的膜蛋白预筛选LCP-FRAP测定法
Vadim Cherezov,Jeffrey Liu,Mark Griffith et al.
Vadim Cherezov et al.
Fluorescence recovery after photobleaching was used to study the diffusion of two integral membrane proteins, bacteriorhodopsin and beta2-adrenergic receptor, in lipidic cubic phase (LCP). We found that the diffusion properties within the L...
Dipole Parallel-Alignment in the Crystal Structure of a Polar Biphenyl: 4'-Acetyl-4-Methoxybiphenyl (AMB) [0.03%]
极性联苯单晶结构中的偶极子平行排列：N,N-二乙基-4-(4'-甲氧基乙酰氨基)联苯（DEMB）
Rainer Glaser,Nathan Knotts,Zhengyu Wu et al.
Rainer Glaser et al.
4'-Acetyl-4-methoxy-biphenyl (AMB) was synthesized via catalytic Suzuki cross-coupling reaction and the crystal structure was determined. The crystals of AMB feature an orthorhombic unit cell with a = 7.900(6) A, b = 5.429(4) A, and c = 26....