Laura N Poloni,Zina Zhu,Nelson Garcia-Vázquez et al.
Laura N Poloni et al.
l-Cystine kidney stones-aggregates of single crystals of the hexagonal form of l-cystine-afflict more than 20 000 individuals in the United States alone. Current therapies are often ineffective and produce adverse side effects. Recognizing ...
Preparation of Microcrystals of Piroxicam Monohydrate by Antisolvent Precipitation via Microfabricated Metallic Membranes with Ordered Pore Arrays [0.03%]
有序孔阵列微成型金属膜在抗溶剂法中制备吡罗昔康单水合物微晶的研究
Rahimah Othman,Goran T Vladisavljević,Elena Simone et al.
Rahimah Othman et al.
Microcrystals of piroxicam (PRX) monohydrate with a narrow size distribution were prepared from acetone/PRX solutions by antisolvent crystallization via metallic membranes with ordered pore arrays. Crystallization was achieved by controlled...
Maximilian O Besenhard,Peter Neugebauer,Otto Scheibelhofer et al.
Maximilian O Besenhard et al.
Size, shape, and polymorphic form are the critical attributes of crystalline particles and represent the major focus of today's crystallization process design. This work demonstrates how crystal properties can be tuned efficiently in soluti...
Leyla-Cann Sögütoglu,Martin Lutz,Hugo Meekes et al.
Leyla-Cann Sögütoglu et al.
The crystal structure of para-methyl-l-phenylalanine at 230 K resembles that of the para-fluorinated analogue from the literature but is commensurately modulated with seven molecules in the asymmetric unit (Z' = 7). At 100 K, the superstruc...
Characterization of Protein Nanocrystals Based on the Reversibility of Crystallization [0.03%]
基于结晶可逆性的蛋白质纳米晶体的表征
Katerina Dörner,Jose M Martin-Garcia,Christopher Kupitz et al.
Katerina Dörner et al.
A new approach is described to screen for protein nanocrystals based on the reversibility of crystallization. Methods to characterize nanocrystals are in strong need to facilitate sample preparation for serial femtosecond X-ray nanocrystall...
Anthonius H J Engwerda,Pim van Schayik,Henjo Jagtenberg et al.
Anthonius H J Engwerda et al.
The scope of Viedma ripening and temperature cycling with respect to chiral molecules has remained mostly limited to molecules with a single stereogenic center, while racemization proceeds through inversion at that particular stereocenter. ...
Unraveling Complexity in the Solid Form Screening of a Pharmaceutical Salt: Why so Many Forms? Why so Few? [0.03%]
药物业盐的固体形式筛选复杂性剖析：为何形成多种形式？又为何形式稀少？
Doris E Braun,Sreenivas R Lingireddy,Mark D Beidelschies et al.
Doris E Braun et al.
The solid form landscape of 5-HT2a antagonist 3-(4-(benzo[d]isoxazole-3-yl)piperazin-1-yl)-2,2-dimethylpropanoic acid hydrochloride (B5HCl) proved difficult to establish. Many crystalline materials were produced by solid form screening, but...
Kyle A Nordquist,Kevin M Schaab,Jierui Sha et al.
Kyle A Nordquist et al.
Systematic surface energy modifications to glass substrates can induce nucleation and improve crystallization outcomes for small molecule active pharmaceutical ingredients (APIs) and proteins. A comparatively broad probe for function is pre...
Investigation of the Evolution of Crystal Size and Shape during Temperature Cycling and in the Presence of a Polymeric Additive Using Combined Process Analytical Technologies [0.03%]
基于多技术过程分析法的温度振荡及高分子助剂作用下晶体尺寸与形状演变的研究
Elena Simone,Anneke R Klapwijk,Chick C Wilson et al.
Elena Simone et al.
Crystal size and shape can be manipulated to enhance the qualities of the final product. In this work the steady-state shape and size of succinic acid crystals, with and without a polymeric additive (Pluronic P123) at 350 mL, scale is repor...
Amelogenin Affects Brushite Crystal Morphology and Promotes Its Phase Transformation to Monetite [0.03%]
enamel蛋白A影响brushite晶体形态并促其相变形成 monetite
Dongni Ren,Qichao Ruan,Jinhui Tao et al.
Dongni Ren et al.
Amelogenin protein is involved in organized apatite crystallization during enamel formation. Brushite (CaHPO4·2H2O), one of the precursors of hydroxyapatite mineralization in vitro, has been used for fabrication of biomaterials for hard ti...