Antimutagenic and antitumor activities of a water-soluble fraction of soursop (syn Graviola, Annona muricata L.) fruit pulp [0.03%]
番荔枝果肉水溶性成分的抗突变和抗肿瘤活性（ synonym Graviola, Annona muricata L.）果肉
Raissa Miranda Scharf,Carine Oliveira Gonçalves,Andreia da Silva Fernandes et al.
Raissa Miranda Scharf et al.
Soursop (Annona muricata) is a tropical tree whose decoction derived from bark, root, seed, or leaf has been used for medicinal uses. In addition, the fruit itself is considered a food, and the juice is utilized to treat heart and liver dis...
Piperlongumine inhibits antioxidant enzymes, increases ROS levels, induces DNA damage and G2/M cell cycle arrest in breast cell lines [0.03%]
辣椒素抑制抗氧化酶，增加ROS水平，诱导DNA损伤和乳腺细胞系中的G2/M细胞周期阻滞
Adrivanio Baranoski,Simone Cristine Semprebon,Bruna Isabela Biazi et al.
Adrivanio Baranoski et al.
Piperlongumine (PLN) is a biologically active alkaloid/amide derived from Piper longum, with known promising anticancer activity. The aim of this study was to compare the antiproliferative activity of PLN in human breast MCF-7 adenocarcinom...
Evaluation of the anti-androgenic and cytotoxic effects of benzophenone-3 in male Sprague-Dawley rats [0.03%]
苯甲酮-3在雄性Sprague-Dawley大鼠中抗雄性和细胞毒性作用的评价
Chi Rim Sung,Byeong Jun Kim,Chan Ju Park et al.
Chi Rim Sung et al.
Benzophenone-3 (BP-3, 2-hydroxy-4-methoxybenzophenone, oxybenzone) is one of the most widely used types of benzophenone organic sunscreen. However, this compound is a potentially harmful toxicant. The aim of this study was 2-fold to: (1) ut...
Marketable 1,3-dimethylamylamine and caffeine-based thermogenic supplements: Regulatory genotoxicity assessment through in vitro and in silico approaches [0.03%]
市场销售的含1,3-二甲基戊胺和咖啡因的减肥食品补充剂：通过体外及基于计算机的进体方法进行监管致突变性评估
Eduardo Kennedy Carrão Dantas,Caroline Lopes Simões Ferreira,Alana da Cunha Goldstein et al.
Eduardo Kennedy Carrão Dantas et al.
The consumption of dietary supplements to enhance physical performance has increased significantly in the last century, especially thermogenic pre-workout supplements. Nevertheless, this industry has faced criticism for inadequate safety me...
Modulatory effects of dietary saturated fatty acids on platelet mitochondrial function following short-term exposure to ambient Particulate Matter (PM2.5) [0.03%]
膳食饱和脂肪酸调节短期暴露于环境细颗粒物(PM2.5)后的血小板线粒体功能的作用机制研究
Wan Shen,Hao Chen,Chiahao Shih et al.
Wan Shen et al.
Exposure to ambient fine particulate matter (PM2.5) was found to produce vascular injury, possibly by activating platelets within days after exposure. The aim of this study was to investigate the modulatory effects of dietary saturated fatt...
Effects of docetaxel on metastatic prostate (DU-145) carcinoma cells cultured as 2D monolayers and 3D multicellular tumor spheroids [0.03%]
紫杉醇对二维单层和三维多细胞球体前列腺癌（DU-145）转移细胞系的影响
Andressa Yuri Fujiike,Larissa Cristina Bastos de Oliveira,Diego Luis Ribeiro et al.
Andressa Yuri Fujiike et al.
Docetaxel (DTX) is one of the chemotherapeutic drugs indicated as a first-line treatment against metastatic prostate cancer (mPCa). This study aimed to compare the impact of DTX on mPCa (DU-145) tumor cells cultured as 2D monolayers and 3D ...
Phytochemical analysis of carotenoid profile in Mentha piperita and Artemisia vulgaris: cytotoxicity in tumoral cells and evaluation of plasmid DNA cleavage [0.03%]
薄荷和飞廉中类胡萝卜素的植物化学分析：肿瘤细胞中的细胞毒性及对质粒DNA切割的影响评估
Altevir Rossato Viana,James Eduardo Lago Londero,Pricila Nass Pinheiro et al.
Altevir Rossato Viana et al.
Several medicinal plants have been administered to cancer patients attributed to their anticarcinogenic and chemoprotective properties, in addition to lower toxicity compared to traditional therapies. The aim was to investigate the antioxid...
Tellimagrandin-I and camptothin a exhibit chemopreventive effects in Salmonella enterica serovar Typhimurium strains and human lymphocytes [0.03%]
泰密林和骆驼藤碱A可防治沙门氏菌Typhimurium菌株及人淋巴细胞的肿瘤生成作用
Amanda Silva Fernandes,Abel Vieira de Melo Bisneto,Luana Santos Silva et al.
Amanda Silva Fernandes et al.
Tellimagrandin-I (TL) and camptothin A (CA) are ellagitannins widely found in diverse plant species. Numerous studies demonstrated their significant biological activities, which include antitumor, antioxidant, and hepatoprotective propertie...
Assessing the disparity: comparative toxicity of Copper in zebrafish larvae exposes alarming consequences of permissible concentrations in Brazil [0.03%]
评估差异：铜对巴西允许浓度的斑马鱼幼体毒性比较显示了令人震惊的后果
Maria Vitória Takemura Mariano,Luana Paganotto Leandro,Karen Kich Gomes et al.
Maria Vitória Takemura Mariano et al.
Copper (Cu) is a naturally occurring metal with essential micronutrient properties. However, this metal might also pose increased adverse environmental and health risks due to industrial and agricultural activities. In Brazil, the maximum a...
Exploring the multifaceted effects of Ammi visnaga: subchronic toxicity, antioxidant capacity, immunomodulatory, and anti-inflammatory activities [0.03%]
探究Ammi visnaga的多面效应：亚慢性毒性、抗氧化能力、免疫调节和抗炎作用
Martin Ndayambaje,Hicham Wahnou,Marieme Sow et al.
Martin Ndayambaje et al.
Ammi visnaga (A. visnaga) is an annual herb that has been used in traditional medicine to treat various ailments attributed to the presence of its bioactive compounds. The purpose of this study was to identify and examine the phytochemical ...