Characterization of SARS-CoV-2 and common cold coronavirus-specific T-cell responses in MIS-C and Kawasaki disease children [0.03%]
MIS-C和川崎病儿童中SARS-CoV-2和普通感冒冠状病毒特异性T细胞反应的特征分析
Li-En Hsieh,Alba Grifoni,John Sidney et al.
Li-En Hsieh et al.
The immunopathogenesis of multisystem inflammatory syndrome (MIS-C) in children that may follow exposure to SARS-CoV-2 is incompletely understood. Here, we studied SARS-CoV-2-specific T cells in MIS-C, Kawasaki disease (KD), and SARS-CoV-2 ...
Persistence of neutralizing antibodies a year after SARS-CoV-2 infection in humans [0.03%]
人类感染SARS-CoV-2一年后中和抗体的持续性
Anu Haveri,Nina Ekström,Anna Solastie et al.
Anu Haveri et al.
Most subjects develop antibodies to SARS-CoV-2 following infection. In order to estimate the duration of immunity induced by SARS-CoV-2 it is important to understand for how long antibodies persist after infection in humans. Here, we assess...
Hydroxychloroquine inhibits proteolytic processing of endogenous TLR7 protein in human primary plasmacytoid dendritic cells [0.03%]
羟氯喹抑制人原代浆细胞样树突状细胞内源性TLR7蛋白的蛋白酶水解加工过程
Claire Cenac,Mariette F Ducatez,Jean-Charles Guéry
Claire Cenac
Toll-like receptor 7 (TLR7) triggers antiviral immune responses through its capacity to recognize ssRNA. Proteolytic cleavage of TLR7 protein is required for its functional maturation in the endosomal compartment. Structural studies demonst...
Inhibition of tumor-associated macrophages by trabectedin improves the antitumor adaptive immunity in response to anti-PD-1 therapy [0.03%]
屈螺酮通过抑制肿瘤相关巨噬细胞提高抗PD-1治疗的抗癌适应性免疫效果
Cristina Belgiovine,Roberta Frapolli,Manuela Liguori et al.
Cristina Belgiovine et al.
A considerable proportion of cancer patients are resistant or only partially responsive to immune checkpoint blockade immunotherapy. Tumor-Associated Macrophages (TAMs) infiltrating the tumor stroma suppress the adaptive immune responses an...
SARS-CoV2 pneumonia recovery is linked to expansion of innate lymphoid cells type 2 expressing CCR10 [0.03%]
SARS-CoV2肺炎恢复与表达CCR10的第2类固有淋巴细胞的扩增有关
André M C Gomes,Guilherme B Farias,Manuel Dias-Silva et al.
André M C Gomes et al.
Accelerate lung repair in SARS-CoV-2 pneumonia is essential for pandemic handling. Innate lymphoid cells (ILCs) are likely players, given their role in mucosal protection and tissue homeostasis. We studied ILC subpopulations at two time poi...
Avery J Lam,Prakruti Uday,Jana K Gillies et al.
Avery J Lam et al.
Treg therapy holds promise as a potentially curative approach to establish immune tolerance in transplantation and autoimmune disease. An outstanding question is whether therapeutic Tregs have the potential to transdifferentiate into effect...
IL-27 mediates anti-inflammatory effect in cigarette smoke induced emphysema by negatively regulating IFN-γ producing cytotoxic CD8+ T cells in mice [0.03%]
在小鼠由香烟烟雾引起的肺气肿模型中，IL-27通过负向调节产生IFN-γ的细胞毒性CD8+ T细胞发挥抗炎作用
Shi-Lin Qiu,Qi-Xiang Sun,Jian-Peng Zhou et al.
Shi-Lin Qiu et al.
Chronic airway inflammation mediated by CD8+ T lymphocytes contributes to the pathogenesis of Chronic obstructive pulmonary disease (COPD). Deciphering the fingerprint of the chronic inflammation orchestrated by CD8+ T cells may allow the d...
Wolfgang Schuh,Lena Baus,Tobit Steinmetz et al.
Wolfgang Schuh et al.
To monitor infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and successful vaccination against coronavirus disease 2019 (COVID-19), the kinetics of neutralizing or blocking anti-SARS-CoV-2 antibody titers need t...
Ex vivo microRNA and gene expression profiling of human Tr1-like cells suggests a role for miR-92a and -125a in the regulation of EOMES and IL-10R [0.03%]
人Tr1样细胞的体外microRNA和基因表达谱分析提示miR-92a和-125a在调节EOMES和IL-10R中的作用
Marco De Simone,Michele Chirichella,Stefan Emming et al.
Marco De Simone et al.
Ex vivo gene expression and miRNA profiling of Eomes+ Tr1-like cells suggested that they represent a differentiation stage that is intermediate between Th1-cells and cytotoxic CD4+ T-cells. Several microRNAs were downregulated in Eomes+ Tr1...
ACKR1 favors transcellular over paracellular T-cell diapedesis across the blood-brain barrier in neuroinflammation in vitro [0.03%]
在体外神经炎症中，ACKR1促进T细胞通过血脑屏障进行跨细胞而非细胞旁的迁移
Luca Marchetti,David Francisco,Sasha Soldati et al.
Luca Marchetti et al.
The migration of CD4+ effector/memory T cells across the blood-brain barrier (BBB) is a critical step in MS or its animal model, EAE. T-cell diapedesis across the BBB can occur paracellular, via the complex BBB tight junctions or transcellu...