Immunity in acute myeloid leukemia: Where the immune response and targeted therapy meet [0.03%]
急性髓细胞白血病中的免疫反应与靶向治疗相遇于何处
Avner Fink,Eric Hung,Indranil Singh et al.
Avner Fink et al.
Acute myeloid leukemia (AML) is a highly aggressive disease with high relapse and mortality rates. Recent years have shown a surge in novel therapeutic development for AML, both in clinical and preclinical stages. These developments include...
mTOR-dependent immunometabolism as Achilles' heel of anticancer therapy [0.03%]
依赖于mTOR的免疫代谢是抗癌治疗的弱点
Clarissa Braun,Thomas Weichhart
Clarissa Braun
Immune cells are important constituents of the tumor microenvironment and essential in eradicating tumor cells during conventional therapies or novel immunotherapies. The mechanistic target of rapamycin (mTOR) signaling pathway senses the i...
Monocytes mediate Salmonella Typhimurium-induced tumor growth inhibition in a mouse melanoma model [0.03%]
单核细胞介导了鼠黑色素瘤模型中鼠伤寒沙门氏菌引起肿瘤生长抑制
Síle A Johnson,Michael J Ormsby,Hannah M Wessel et al.
Síle A Johnson et al.
The use of bacteria as an alternative cancer therapy has been reinvestigated in recent years. SL7207: an auxotrophic Salmonella enterica serovar Typhimurium aroA mutant with immune-stimulatory potential has proven a promising strain for thi...
The soluble cytoplasmic tail of CD45 regulates T-cell activation via TLR4 signaling [0.03%]
CD45的可溶性胞内段通过TLR4信号转导调节T细胞活化
Alexander Puck,Sarojinidevi Künig,Madhura Modak et al.
Alexander Puck et al.
The soluble cytoplasmic tail of CD45 (ct-CD45) is a cleavage fragment of CD45, that is generated during the activation of human phagocytes. Upon release to the extracellular space, ct-CD45 binds to human T cells and inhibits their activatio...
Annika E Peters,Konrad Knöpper,Anika Grafen et al.
Annika E Peters et al.
The capacity to develop immunological memory is a hallmark of the adaptive immune system. To investigate the role of Samd3 for cellular immune responses and memory development, we generated a conditional knock-out mouse including a fluoresc...
Interleukin-7-dependent nonclassical monocytes and CD40 expression are affected in children with type 1 diabetes [0.03%]
依赖白细胞介素-7的非经典单核细胞和CD40表达在1型糖尿病儿童中受到影响
Paul Hehenkamp,Maximilian Hoffmann,Sebastian Kummer et al.
Paul Hehenkamp et al.
The important role of IL-7 in the generation of self-reactive T-cells in autoimmune diseases is well established. Recent studies on autoimmunity-associated genetic polymorphisms indicated that differential IL-7 receptor (IL-7R) expression o...
Type I interferon supports γδ T-cell homeostasis and immunity through direct and indirect receptor signaling in mice [0.03%]
I型干扰素通过直接和间接受体信号维持小鼠的γδT细胞稳态与免疫反应
Rasmus Agerholm,Darshana Kadekar,John Rizk et al.
Rasmus Agerholm et al.
Interleukin (IL)-17-producing gamma delta (γδ) T (γδT17) cells are an essential part of innate type 3 immunity against numerous pathogens. At the same time, a large body of evidence from mouse models and human clinical studies suggests ...
MHC haplotype and B cell autoimmunity: Correlation with pathogenic IgG autoantibody subclasses and Fc glycosylation patterns [0.03%]
MHC等位基因和B细胞自身免疫性：与致病性IgG自身抗体亚类及其Fc糖基化模式的相关性
Larissa Nogueira Almeida,Ann-Katrin Clauder,Lingzhang Meng et al.
Larissa Nogueira Almeida et al.
Genome-wide association studies (GWAS) have identified many genes that are associated with the development of certain autoimmune disorders, but the MHC haplotypes still represent the most prevalent genetic risk factor for many autoimmune di...
Theres Klewer,Ljubica Bakic,Thomas Müller-Reichert et al.
Theres Klewer et al.
Crosslinking of FcεRI-bound IgE triggers the release of a large number of biologically active, potentially anaphylactic compounds by mast cells. FcεRI activation ought to be well-controlled to restrict adverse activation. As mast cells ar...
Compartmentalized multicellular crosstalk in lymph nodes coordinates the generation of potent cellular and humoral immune responses [0.03%]
淋巴结中隔的多细胞交叉通讯协调了高效免疫反应的生成
Justine Poirot,Jasna Medvedovic,Coline Trichot et al.
Justine Poirot et al.
Distributed throughout the body, lymph nodes (LNs) constitute an important crossroad where resident and migratory immune cells interact to initiate antigen-specific immune responses supported by a dynamic 3-dimensional network of stromal ce...