Sex differences regulate immune responses in experimental autoimmune encephalomyelitis and multiple sclerosis [0.03%]
性别差异调节实验性自身免疫性脑脊髓炎和多发性硬化中的免疫反应
Lucy Ryan,Kingston H G Mills
Lucy Ryan
MS is an autoimmune disease of the CNS that afflicts over 2.5 million people worldwide. There are striking sex differences in the susceptibility to and progression of this disease in humans. Females are twice as likely to develop MS than ma...
An efficient single-cell based method for linking human T cell phenotype to T cell receptor sequence and specificity [0.03%]
一种高效基于单细胞的人类T细胞表型与T细胞受体序列和特异性的关联方法
Ilka Wahl,Sandro Hoffmann,Rebecca Hundsdorfer et al.
Ilka Wahl et al.
Single-cell antigen-receptor gene amplification and sequencing platforms have been used to characterize T cell receptor (TCR) repertoires but typically fail to generate paired full-length gene products for direct expression cloning and do n...
PDGFRα-lineage origin directs monocytes to trafficking proficiency to support peripheral immunity [0.03%]
PDGFRα-谱系起源指导单核细胞高效转运以支持外周免疫
Yu-Tung Li,Sho Yamazaki,Eiichi Takaki et al.
Yu-Tung Li et al.
Multiple embryonic precursors give rise to leukocytes in adults while the lineage-based functional impacts are underappreciated. Mesodermal precursors expressing PDGFRα appear transiently during E7.5-8.5 descend to a subset of Lin- Sca1+ K...
Heavy chain-only antibody genes in fish evolved to generate unique CDR3 repertoire [0.03%]
鱼类中仅重链的抗体基因进化出独特的CDR3库
Kamala Anumukonda,Malcolm Francis,Peter Currie et al.
Kamala Anumukonda et al.
In addition to conventional immunoglobulin, camelids and cartilaginous fish express a special class of antibody that consists only of heavy (H) chain (HCAbs). In the holocephalan elephantfish, there are two HCAb classes, one of which has ev...
Longitudinal SARS-CoV-2 seroprevalence in Portugal and antibody maintenance 12 months after infection [0.03%]
葡萄牙的纵向SARS-CoV-2血清阳性率和感染后12个月的抗体维持情况
Luísa Canto E Castro,Andreia Gomes,Marta Serrano et al.
Luísa Canto E Castro et al.
During the COVID-19 pandemic, Portugal has experienced three distinct SARS-CoV-2 infection waves. We previously documented the prevalence of SARS-CoV-2 immunity, measured by specific antibodies, in September 2020, 6 months after the initial...
Randomized Controlled Trial
European journal of immunology. 2022 Jan;52(1):149-160. DOI:10.1002/eji.202149619 2022
The IFN-inducible GTPase IRGB10 regulates viral replication and inflammasome activation during influenza A virus infection in mice [0.03%]
IFN诱导的GTP酶IRGB10在小鼠A型流感病毒感染过程中调节病毒复制和炎性小体激活
Shelbi Christgen,David E Place,Min Zheng et al.
Shelbi Christgen et al.
The upregulation of interferon (IFN)-inducible GTPases in response to pathogenic insults is vital to host defense against many bacterial, fungal, and viral pathogens. Several IFN-inducible GTPases play key roles in mediating inflammasome ac...
Single-cell resolution of plasma cell fate programming in health and disease [0.03%]
健康与疾病中浆细胞命运编程的单细胞分辨率解析
Céline Delaloy,Wolfgang Schuh,Hans-Martin Jäck et al.
Céline Delaloy et al.
Long considered a homogeneous population dedicated to antibody secretion, plasma cell phenotypic and functional heterogeneity is increasingly recognized. Plasma cells were first segregated based on their maturation level, but the complexity...
SLAMF7 selectively favors degranulation to promote cytotoxicity in human NK cells [0.03%]
SLAMF7选择性地促进人类NK细胞的脱颗粒以增强其细胞毒性作用
Arturo Gutierrez-Guerrero,Ismael Mancilla-Herrera,Jose L Maravillas-Montero et al.
Arturo Gutierrez-Guerrero et al.
NK cells play an important role in immunity by recognizing and eliminating cells undergoing infection or malignant transformation. This role is dependent on the ability of NK cells to lyse targets cells in a perforin-dependent mechanism and...
Altered increase in STAT1 expression and phosphorylation in severe COVID-19 [0.03%]
严重COVID-19中STAT1表达和磷酸化的改变增加
Hector Rincon-Arevalo,Arman Aue,Jacob Ritter et al.
Hector Rincon-Arevalo et al.
The interferon pathway, a key antiviral defense mechanism, is being considered as a therapeutic target in COVID-19. Both, substitution of interferon and JAK/STAT inhibition to limit cytokine storms have been proposed. However, little is kno...
MALT1 protease function in regulatory T cells induces MYC activity to promote mitochondrial function and cellular expansion [0.03%]
调节T细胞中的MALT1蛋白酶功能促进线粒体功能和细胞扩增通过激活MYC活性来实现
Marc Rosenbaum,Theresa Schnalzger,Thomas Engleitner et al.
Marc Rosenbaum et al.
Regulatory T cells (Tregs) are essential for the inhibition of immunity and the maintenance of tissue homeostasis. Signals from the T-cell antigen receptor (TCR) are critical for early Treg development, their expansion, and inhibitory activ...