Imprint of unconventional T-cell response in acute hepatitis C persists despite successful early antiviral treatment [0.03%]
急性丙型肝炎中尽管早期抗病毒治疗成功但仍持续存在的非常规T细胞反应痕迹
Yanqin Du,Tanvi Khera,Benedikt Strunz et al.
Yanqin Du et al.
Unconventional T cells (UTCs) are a heterogeneous group of T cells that typically exhibit rapid responses toward specific antigens from pathogens. Chronic hepatitis C virus (HCV) infection causes dysfunction of several subsets of UTCs. This...
COVID-19-specific metabolic imprint yields insights into multiorgan system perturbations [0.03%]
COVID-19特异代谢印记揭示多器官系统异常
Martin Cornillet,Benedikt Strunz,Olav Rooyackers et al.
Martin Cornillet et al.
Corona disease 2019 (COVID-19) affects multiple organ systems. Recent studies have indicated perturbations in the circulating metabolome linked to COVID-19 severity. However, several questions pertain with respect to the metabolome in COVID...
CRISPR/Cas9 editing in conditionally immortalized HoxB8 cells for studying gene regulation in mouse dendritic cells [0.03%]
用于研究小鼠树突细胞基因调控的条件性传代HoxB8细胞中的CRISPR/Cas9编辑
Huaming Xu,Thomas Look,Sujeethkumar Prithiviraj et al.
Huaming Xu et al.
HoxB8 multipotent progenitors (MPP) are obtained by expression of the estrogen receptor hormone binding domain (ERHBD) HoxB8 fusion gene in mouse BM cells. HoxB8 MPP generate (i) the full complement of DC subsets (cDC1, cDC2, and pDC) in vi...
AIDS patient with severe T cell depletion achieved control but not clearance of SARS-CoV-2 infection [0.03%]
严重T细胞耗竭的艾滋病患者实现对SARS-CoV-2感染的控制但并未清除病毒
Michele Spinicci,Alessio Mazzoni,Beatrice Borchi et al.
Michele Spinicci et al.
A late presenter AIDS patient with severe T cell depletion presented non-severe COVID-19 symptoms, with prolonged viral shedding. Our case report supports the hypothesis that an effective T cell response may be dispensable for the control o...
An integrative genomics approach identifies KDM4 as a modulator of trained immunity [0.03%]
整合基因组学方法识别KDM4作为训练免疫的调节因子
Simone J C F M Moorlag,Vasiliki Matzaraki,Jelmer H van Puffelen et al.
Simone J C F M Moorlag et al.
Innate immune cells are able to build memory characteristics via a process termed "trained immunity." Host factors that influence the magnitude of the individual trained immunity response remain largely unknown. Using an integrative genomic...
TLR9 signalling inhibits Plasmodium liver infection by macrophage activation [0.03%]
TLR9信号通路通过巨噬细胞活化抑制疟原虫的肝脏感染
Maximilian Kordes,Louise Ormond,Sebastian Rausch et al.
Maximilian Kordes et al.
Recognition of pathogen-associated molecular patterns (PAMPs) through Toll-like receptors (TLRs) plays a pivotal role in first-line pathogen defense. TLRs are also likely triggered during a Plasmodium infection in vivo by parasite-derived c...
Immuno-oncological role of 20S proteasome alpha-subunit 3 in aggravating the progression of esophageal squamous cell carcinoma [0.03%]
20S蛋白酶体α亚基3在加速食管鳞状细胞癌进展中的免疫肿瘤学作用
Jinyan Liu,Jingwen Shao,Chaoqi Zhang et al.
Jinyan Liu et al.
PSMA3, a member of the proteasome subunit, has been shown to play a major player in protein degradation. Reportedly, PSMA3 functions as a negative regulator in various cancers including colon, pancreatic and gastric cancers. However, the co...
T cells expressing multiple co-inhibitory molecules in acute malaria are not exhausted but exert a suppressive function in mice [0.03%]
急性疟疾中表达多种共抑制分子的T细胞并不耗竭但在小鼠体内发挥抑制功能
Johannes Brandi,Cari Lehmann,Lea-Christina Kaminski et al.
Johannes Brandi et al.
Overwhelming activation of T cells in acute malaria is associated with severe outcomes. Thus, counter-regulation by anti-inflammatory mechanisms is indispensable for an optimal resolution of disease. Using Plasmodium berghei ANKA (PbA) infe...
Notch1 deficiency alters the migratory behavior of developing T cells and calcium signaling in the thymus of medaka [0.03%]
Notch1缺乏改变七复合体发育T细胞的迁移行为和胸腺中的钙信号通路
Narges Aghaallaei,Daigo Inoue,Eva Hasel de Carvalho et al.
Narges Aghaallaei et al.
The differentiation of T cells from lymphoid progenitors in the thymus follows sequential developmental stages that constantly require interaction with thymic epithelial cells. Several distinct aspects of early T cell development depend on ...
Profiling the specificity of clonally expanded plasma cells during chronic viral infection by single-cell analysis [0.03%]
单细胞分析在慢性病毒感染过程中克隆扩增的浆细胞特异性的谱型分析
Daniel Neumeier,Alessandro Pedrioli,Alessandro Genovese et al.
Daniel Neumeier et al.
Plasma cells and their secreted antibodies play a central role in the long-term protection against chronic viral infection. However, due to experimental limitations, a comprehensive description of linked genotypic, phenotypic, and antibody ...