Soluble CD137 is a novel serum marker of liver cirrhosis in patients with hepatitis C and alcohol-associated disease etiology [0.03%]
可溶性CD137是一种新型的肝硬化血清标志物，见于丙型肝炎和酒精相关的疾病患者中
Kilian Weigand,Georg Peschel,Jonathan Grimm et al.
Kilian Weigand et al.
Defective T-cell functions play a role in the persistence of HCV infection. Activated T cells express CD137, which costimulates antivirus T-cell responses, and this activity is antagonized by soluble CD137 (sCD137). Here, we show that in se...
Phospholipase activity of acyloxyacyl hydrolase induces IL-22-producing CD1a-autoreactive T cells in individuals with psoriasis [0.03%]
酰氧基酸酶的磷脂酶活性可诱导自身反应性CD1a⁺IL-22+T细胞参与银屑病发病
Randeep Singh,Yi-Ling Chen,Soo Weei Ng et al.
Randeep Singh et al.
Psoriasis is a chronic inflammatory skin disease characterized by Th17 responses. Recent evidence has identified Langerhans cells to have a key role in disease pathogenesis, with constitutive high expression of CD1a and capacity to present ...
Dynamics of IL-15/IL-15R-α expression in response to HSV-1 infection reveal a novel mode of viral immune evasion counteracted by iNKT cells [0.03%]
HSV-1感染后IL-15/IL-15R-α的表达动力学揭示了病毒免疫逃避的一种新机制并被iNKT细胞抑制
Michał J Sobkowiak,Dominic Paquin-Proulx,Lidija Bosnjak et al.
Michał J Sobkowiak et al.
Herpes simplex virus type 1 (HSV-1) infects and persists in most of the human population. Interleukin-15 (IL-15) has an important role in the activation of cell-mediated immune responses and acts in complex with IL-15 receptor alpha (IL-15R...
Our latest edition of Flow Cytometry Guidelines for basic and clinical immunologists! [0.03%]
最新版《流式细胞术指南》助力基础与临床免疫学研究！
James Di Santo,Nadja Bakocevic
James Di Santo
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) [0.03%]
免疫学研究中流式细胞术和细胞分选的使用指南（第三版）
Andrea Cossarizza,Hyun-Dong Chang,Andreas Radbruch et al.
Andrea Cossarizza et al.
The third edition of Flow Cytometry Guidelines provides the key aspects to consider when performing flow cytometry experiments and includes comprehensive sections describing phenotypes and functional assays of all major human and murine imm...
The unexpected contribution of conventional type 1 dendritic cells in driving antibody responses [0.03%]
关于常规I型树突细胞驱动抗体反应的意外发现
Thiago M Steiner,William R Heath,Irina Caminschi
Thiago M Steiner
Antibodies are hallmarks of most effective vaccines. For successful T-dependent antibody responses, conventional dendritic cells (cDC) have been largely attributed the role of priming T cells. By contrast, follicular dendritic cells and mac...
Hobit and Blimp-1 instruct the differentiation of iNKT cells into resident-phenotype lymphocytes after lineage commitment [0.03%]
嗜胞病毒和Blimp-1在命定决定后指引iNKT细胞分化成驻留型淋巴细胞
Natasja Am Kragten,Renske Lre Taggenbrock,Loreto Parga Vidal et al.
Natasja Am Kragten et al.
iNKT cells are CD1d-restricted T cells that play a pro-inflammatory or regulatory role in infectious and autoimmune diseases. Thymic precursors of iNKT cells eventually develop into distinct iNKT1, iNKT2, and iNKT17 lineages in the peripher...
Metabolic reprograming shapes neutrophil functions in severe COVID-19 [0.03%]
代谢重编程塑造了重症COVID-19中中性粒细胞的功能
Rebecca Borella,Sara De Biasi,Annamaria Paolini et al.
Rebecca Borella et al.
To better understand the mechanisms at the basis of neutrophil functions during SARS-CoV-2, we studied patients with severe COVID-19 pneumonia. They had high blood proportion of degranulated neutrophils and elevated plasma levels of myelope...
Robust induction of neutralizing antibodies against the SARS-CoV-2 Delta variant after homologous Spikevax or heterologous Vaxzevria-Spikevax vaccination [0.03%]
同源Spikevax或异源Vaxzevria-Spikevax疫苗接种后对SARS-CoV-2 Delta变异株产生中和抗体的稳健诱导
Swantje I Hammerschmidt,Christoph Thurm,Berislav Bošnjak et al.
Swantje I Hammerschmidt et al.
Sera of vaccines were assessed by surrogate virus neutralization tests for their capacity to neutralize the SARS-CoV-2 Delta variant. Homologous prime-boost immunization with Moderna's Spikevax as well as heterologous immunization with Astr...
Novel approach to monitor intravenous immunoglobulin pharmacokinetics in humans using polymorphic determinants in IgG1 constant domains [0.03%]
利用IgG1恒定区的多态性决定子监测人体内静脉注射免疫球蛋白药代动力学的新方法
Sander J van Tilburg,Bart C Jacobs,Pleuni Ooijevaar-de Heer et al.
Sander J van Tilburg et al.
Clinical efficacy of intravenous immunoglobulin treatment (IVIg) is related to its pharmacokinetic (PK) profile. Its usual evaluation, by measuring serum total IgG levels, is imprecise, because IVIg cannot be distinguished from endogenous I...