Initial properdin binding contributes to alternative pathway activation at the surface of viable and necrotic cells [0.03%]
初始 Properdin 结合有助于活细胞和坏死细胞表面的补体替代途径激活
Mieke F van Essen,Nicole Schlagwein,Elisa M P van den Hoven et al.
Mieke F van Essen et al.
Properdin, the only known positive regulator of the complement system, stabilizes the C3 convertase, thereby increasing its half-life. In contrast to most other complement factors, properdin is mainly produced extrahepatically by myeloid ce...
Systemic lupus erythematosus patients contain B-cell receptor repertoires sensitive to immunosuppressive drugs [0.03%]
系统性红斑狼疮患者的免疫抑制药物敏感B细胞受体库
Meiyu Wu,Wenjing Pan,Chen Jia et al.
Meiyu Wu et al.
Immune repertoire (IR) during treatment may be a surrogate biomarker for disease response. Changes of the IR in systemic lupus erythematosus patients in response to immunosuppressive drugs were identified in ten SLE patients. Patients provi...
A population of naive-like CD4+ T cells stably polarized to the TH 1 lineage [0.03%]
一类稳定分化入Th1谱系的Naïve样CD4⁺T细胞群
Jonathan W Lo,Maria Vila de Mucha,Stephen Henderson et al.
Jonathan W Lo et al.
T-bet is the lineage-specifying transcription factor for CD4+ TH 1 cells. T-bet has also been found in other CD4+ T cell subsets, including TH 17 cells and Treg, where it modulates their functional characteristics. However, we lack informat...
Guidelines for standardizing T-cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes [0.03%]
标准化T细胞细胞计量检测以链接1型糖尿病生物标志物、机制和疾病结果的指导原则
Jennie H M Yang,Kirsten A Ward-Hartstonge,Daniel J Perry et al.
Jennie H M Yang et al.
Cytometric immunophenotyping is a powerful tool to discover and implement T-cell biomarkers of type 1 diabetes (T1D) progression and response to clinical therapy. Although many discovery-based T-cell biomarkers have been described, to date,...
B-cell modulation with anti-CD79b antibodies ameliorates experimental autoimmune encephalitis in mice [0.03%]
抗CD79b抗体调节B细胞可改善小鼠自身免疫性脑炎症状
Kerstin Renner,Sophia Neumayer,Yvonne Talke et al.
Kerstin Renner et al.
B cells play a major role in the pathogenesis of many autoimmune diseases like MS, rheumatoid arthritis, or systemic lupus erythematosus. Depletion of B cells with anti-CD20 antibodies is an established therapy for MS. However, total B-cell...
Glutamine promotes the generation of B10+ cells via the mTOR/GSK3 pathway [0.03%]
谷氨酰胺通过mTOR/GSK3信号促进B10+细胞的生成
Julie Mielle,Jacques Morel,Jamila Elhmioui et al.
Julie Mielle et al.
Alterations in cell metabolism can shift the differentiation of immune cells toward a regulatory or inflammatory phenotype, thus, opening up new therapeutic opportunities for immune-related diseases. Indeed, growing knowledge on T- cell met...
Adenovirus vectors activate Vδ2+ γδT cells in a type I interferon-, TNF-, and IL-18-dependent manner [0.03%]
腺病毒载体通过I型干扰素、TNF和IL-18依赖的方式激活Vδ2⁺ γδT细胞
Nicholas M Provine,Ali Amini,Lucy C Garner et al.
Nicholas M Provine et al.
Vδ2+ γδT cells are unconventional T cells that can be activated by cytokines without TCR signaling. Adenovirus vaccine vectors activated Vδ2+ γδT cells in an interleukin 18-, TNF-, and type I interferon-dependent manner. This stimulat...
Poly I:C and STING agonist-primed DC increase lymphoid tissue polyfunctional HIV-1-specific CD8+ T cells and limit CD4+ T-cell loss in BLT mice [0.03%]
聚I:C和STING激动剂诱导的树突状细胞增加BLT小鼠生发中心组织多功能HIV-1特异性CD8⁺T细胞并限制CD4⁺T细胞损耗
Marta Calvet-Mirabent,Daniel T Claiborne,Maud Deruaz et al.
Marta Calvet-Mirabent et al.
Effective function of CD8+ T cells and enhanced innate activation of DCs in response to HIV-1 is linked to protective antiviral immunity in controllers. Manipulation of DC targeting the master regulator TANK-binding Kinase 1 (TBK1) might be...
Targeted delivery of a vaccine protein to Langerhans cells in the human skin via the C-type lectin receptor Langerin [0.03%]
疫苗蛋白通过C型凝集素受体Langerin靶向传递到人体皮肤的朗格汉斯细胞中
Lydia Bellmann,Helen Strandt,Claudia Zelle-Rieser et al.
Lydia Bellmann et al.
Human skin is a preferred vaccination site as it harbors multiple dendritic cell (DC) subsets, which display distinct C-type lectin receptors (CLR) that recognize pathogens. Antigens can be delivered to CLR by antibodies or ligands to boost...
BOB.1/OBF.1 is required during B-cell ontogeny for B-cell differentiation and germinal center function [0.03%]
BOB.1/OBF.1是B淋巴细胞发育过程中B淋巴细胞分化和生发中心功能所必需的
Annika C Betzler,Katja Fiedler,Thomas K Hoffmann et al.
Annika C Betzler et al.
BOB.1/OBF.1 is a lymphocyte-specific transcriptional co-activator of octamer-dependent transcription. It regulates the expression of genes important for lymphocyte physiology together with the Oct-1 and Oct-2 transcription factors. So far, ...