Targeting Bcl6 in the TREX1 D18N murine model ameliorates autoimmunity by modulating T-follicular helper cells and germinal center B cells [0.03%]
靶向TREX1 D18N小鼠模型中的Bcl6可调节T滤泡辅助细胞和生发中心B细胞以缓解自身免疫反应
Rajkumar Venkatadri,Vikram Sabapathy,Murat Dogan et al.
Rajkumar Venkatadri et al.
The Three Prime Repair EXonuclease I (TREX1) is critical for degrading post-apoptosis DNA. Mice expressing catalytically inactive TREX1 (TREX1 D18N) develop lupus-like autoimmunity due to chronic sensing of undegraded TREX1 DNA substrates, ...
Structure-guided stabilization of pathogen-derived peptide-HLA-E complexes using non-natural amino acids conserves native TCR recognition [0.03%]
基于结构的工程改造使病原体衍生肽-HLA-E复合物稳定，并且使用非天然氨基酸可以保持其原有的TCR识别功能
Claire Barber,Victoria Arena De Souza,Rachel L Paterson et al.
Claire Barber et al.
The nonpolymorphic class Ib molecule, HLA-E, primarily presents peptides from HLA class Ia leader peptides, providing an inhibitory signal to NK cells via CD94/NKG2 interactions. Although peptides of pathogenic origin can also be presented ...
Tumor-associated human dendritic cell subsets: Phenotype, functional orientation, and clinical relevance [0.03%]
肿瘤相关的人树突状细胞亚群：表型、功能取向和临床意义
Ioana Plesca,Luise Müller,Jan P Böttcher et al.
Ioana Plesca et al.
DCs play a pivotal role in orchestrating innate and adaptive antitumor immunity. Activated DCs can produce large amounts of various proinflammatory cytokines, initiate T-cell responses, and exhibit direct cytotoxicity against tumor cells. T...
Dendritic cell functions in vivo: A user's guide to current and next- generation mutant mouse models [0.03%]
小鼠功能缺失及基因敲入模型在树突状细胞研究中的应用指南
Marc Dalod,Stefanie Scheu
Marc Dalod
DCs do not just excel in antigen presentation. They orchestrate information transfer from innate to adaptive immunity by sensing and integrating a variety of danger signals, and translating them to naïve T cells, to mount specifically tail...
Peter Aichele,Christoph Neumann-Haefelin,Stephan Ehl et al.
Peter Aichele et al.
Recent findings indicate that many immunopathologies are at their roots a consequence of impaired immune responses ("too little" immunity) and not the result of primarily exaggerated immune responses ("too much" immunity). We have summarize...
Global koff -rates of polyclonal T-cell populations merge subclonal avidities and predict functionality [0.03%]
全局koff速率可汇总统克隆亲和力预测多克隆T细胞群体的功能性
Philipp Lückemeier,Katherine L Molter,Sebastian Jarosch et al.
Philipp Lückemeier et al.
The avidity of TCRs for peptide-major histocompatibility complexes (pMHCs) is a governing factor in how T cells respond to antigen. TCR avidity is generally linked to T-cell functionality and there is growing evidence for distinct roles of ...
Innate lymphoid cell characterization in the rat and their correlation to gut commensal microbes [0.03%]
小鼠固有淋巴细胞的表征及其与肠道共生菌的相关性研究
Amanda Sudworth,Filip M Segers,Bahtiyar Yilmaz et al.
Amanda Sudworth et al.
Innate lymphoid cells (ILCs) are important for tissue immune homeostasis, and are thoroughly characterized in mice and humans. Here, we have performed in-depth characterization of rat ILCs. Rat ILCs were identified based on differential exp...
Decoding the signaling profile of hematopoietic progenitor kinase 1 (HPK1) in innate immunity: A proteomic approach [0.03%]
蛋白组学方法在天然免疫中破解脯氨酰羟化酶家族成员HPK1信号特征谱式
Almke Bader,Michael Winkelmann,Ignasi Forné et al.
Almke Bader et al.
Signaling via β2 integrins (CD11/CD18) as well as TCRs and BCRs involves similar pathways. However, the activation of the same signaling molecule can result in opposing effects. One such example is the hematopoietic progenitor kinase 1 (HP...
SARS-CoV-2 infection activates dendritic cells via cytosolic receptors rather than extracellular TLRs [0.03%]
新型冠状病毒感染通过细胞质中的受体而非细胞外Toll样受体活化树突状细胞
Lieve E H van der Donk,Julia Eder,John L van Hamme et al.
Lieve E H van der Donk et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), an infectious disease characterized by strong induction of inflammatory cytokines, progressive lung inflammation, and potentially multi...
Stereotyped B-cell responses are linked to IgG constant region polymorphisms in multiple sclerosis [0.03%]
立体的B细胞反应与多发性硬化症IgG恒定区多态性的联系
Ida Lindeman,Justyna Polak,Shuo-Wang Qiao et al.
Ida Lindeman et al.
Clonally related B cells infiltrate the brain, meninges, and cerebrospinal fluid of MS patients, but the mechanisms driving the B-cell response and shaping the immunoglobulin repertoires remain unclear. Here, we used single-cell full-length...