Cytokine-induced transient monocyte IL-7Ra expression and the serum milieu in tuberculosis [0.03%]
细胞因子诱导的单核细胞IL-7Ra瞬时表达和结核病的血清环境
Jean De Dieu Harelimana,Hubert Senanu Ahor,Bastian Benner et al.
Jean De Dieu Harelimana et al.
Bacterial components and cytokines induce IL-7 receptor (IL-7Rα) expression in monocytes. Aberrant low IL-7Rα expression of monocytes has been identified as a feature of tuberculosis immunopathology. Here, we investigated the mechanisms u...
Alessio Bevilacqua,Zhiyu Li,Ping-Chih Ho
Alessio Bevilacqua
Cytotoxic CD8+ T cells are a key element of the adaptative immune system to protect the organism against infections and malignant cells. During their activation and response, T cells undergo different metabolic pathways to support their ene...
Augmented neutralization of SARS-CoV-2 Omicron variant by boost vaccination and monoclonal antibodies [0.03%]
通过加强疫苗接种和单克隆抗体对SARS-CoV-2奥密克戎变异株的增效中和作用
Sebastian R Schulz,Markus Hoffmann,Edith Roth et al.
Sebastian R Schulz et al.
Effective vaccines and monoclonal antibodies have been developed against coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the appearance of virus variants with higher trans...
Neutralizing antibody responses 300 days after SARS-CoV-2 infection and induction of high antibody titers after vaccination [0.03%]
感染新冠病毒300天后的中和抗体反应及接种疫苗后的高滴度抗体诱导
Doris Urlaub,Natalie Wolfsdorff,Jan-Erik Hoffmann et al.
Doris Urlaub et al.
Neutralizing antibodies against SARS-CoV-2 are important to protect against infection and/or disease. Using an assay to detect antibodies directed against the receptor binding domain (RBD) of SARS-CoV-2 Spike, we identified individuals with...
Resident memory CD4+ T lymphocytes mobilize from bone marrow to contribute to a systemic secondary immune reaction [0.03%]
resident记忆CD4⁺T淋巴细胞从骨髓动员参与全身继发性免疫反应
Carla Cendón,Weijie Du,Pawel Durek et al.
Carla Cendón et al.
Resident memory T lymphocytes (TRM ) of epithelial tissues and the Bm protect their host tissue. To what extent these cells are mobilized and contribute to systemic immune reactions is less clear. Here, we show that in secondary immune reac...
Human dendritic cell subsets: An updated view of their ontogeny and functional specialization [0.03%]
人类树突细胞亚群：其发生和功能特化的最新观点
Elodie Segura
Elodie Segura
Human DCs have been divided into several subsets based on their phenotype and ontogeny. Recent high throughput single-cell methods have revealed additional heterogeneity within human DC subsets, and new subpopulations have been proposed. In...
Specificity of mouse and human Fcgamma receptors and their polymorphic variants for IgG subclasses of different species [0.03%]
小鼠和人类的Fcgamma受体及其多态性变异体与不同物种IgG亚类的特异性
Yu Wang,Vanessa Krémer,Bruno Iannascoli et al.
Yu Wang et al.
IgG is the predominant antibody class generated during infections and used for the generation of therapeutic antibodies. Antibodies are mainly characterized in or generated from animal models that support particular infections, respond to p...
Integrin activation enables rapid detection of functional Vδ1+ and Vδ2+ γδ T cells [0.03%]
整合素活化可实现功能性Vδ1+和Vδ2+γδT细胞的快速检测
Nicola Herold,Anna Schöllhorn,Adrian Feile et al.
Nicola Herold et al.
Conformational change of the β2 integrin lymphocyte function-associated antigen 1 (LFA-1) is an early marker of T cell activation. A protocol using the mAb clone m24 recognizing the active, extended high-affinity conformation has been prev...
The presence of serum anti-SARS-CoV-2 IgA appears to protect primary health care workers from COVID-19 [0.03%]
血清中的SARS-CoV-2 IgA抗体存在似乎可以保护医护人员免受新冠病毒感染
Viktoria Hennings,Karolina Thörn,Sofie Albinsson et al.
Viktoria Hennings et al.
The patterns of humoral and cellular responses to SARS-CoV-2 were studied in Swedish primary health care workers (n = 156) for 6 months during the Covid-19 pandemic. Serum IgA and IgG to SARS-CoV-2, T-cell proliferation and cytokine secreti...