LCMV induced downregulation of HVEM on antiviral T cells is critical for an efficient effector response [0.03%]
LCMV诱导的抗病毒T细胞上HVEM下调对于有效的效应反应是关键的
Patrizia Diethelm,Iwana Schmitz,Irina Iten et al.
Patrizia Diethelm et al.
T-cell responses against tumors and pathogens are critically shaped by cosignaling molecules providing a second signal. Interaction of herpes virus entry mediator (HVEM, CD270, TNFRSF14) with multiple ligands has been proposed to promote or...
Dysfunction of S100A4+ effector memory CD8+ T cells aggravates asthma [0.03%]
S100A4+效应记忆CD8+T细胞功能障碍加重哮喘症状
Huilei Zhang,Shuangqing Liu,Yanan Li et al.
Huilei Zhang et al.
Progressive loss of effector functions, especially IFN-γ secreting capability, in effector memory CD8+ T (CD8+ TEM ) cells plays a crucial role in asthma worsening. However, the mechanisms of CD8+ TEM cell dysfunction remain elusive. Here,...
GVHD, IBD, and primary immunodeficiencies: The gut as a target of immunopathology resulting from impaired immunity [0.03%]
移植物抗宿主病、炎症性肠病和原发性免疫缺陷：肠道作为由免疫功能受损引起的免疫病理损伤的目标器官
Robert Zeiser,Klaus Warnatz,Stephan Rosshart et al.
Robert Zeiser et al.
The intestinal tract is the largest immunological organ in the body and has a central function of regulating local immune responses, as the intestinal epithelial barrier is a location where the immune system interacts with the gut microbiom...
Platelets accumulate in lung lesions of tuberculosis patients and inhibit T-cell responses and Mycobacterium tuberculosis replication in macrophages [0.03%]
血小板在结核病患者的肺部病变中聚集并抑制T细胞反应和巨噬细胞中的结核分枝杆菌复制
Marco P La Manna,Valentina Orlando,Giusto D Badami et al.
Marco P La Manna et al.
Platelets regulate human inflammatory responses that lead to disease. However, the role of platelets in tuberculosis (TB) pathogenesis is still unclear. Here, we show that patients with active TB have a high number of platelets in periphera...
The TLR-chaperone CNPY3 is a critical regulator of NLRP3-inflammasome activation [0.03%]
TLR伴行蛋白CNPY3是NLRP3炎性小体活化的关键调控因子
Mohamed Ghait,Ralf A Husain,Shivalee N Duduskar et al.
Mohamed Ghait et al.
TLRs mediate the recognition of microbial and endogenous insults to orchestrate the inflammatory response. TLRs localize to the plasma membrane or endomembranes, depending on the member, and rely critically on ER-resident chaperones to matu...
Neutralizing antibodies to SARS-CoV-2 Omicron variant after third mRNA vaccination in health care workers and elderly subjects [0.03%]
第三剂mRNA疫苗接种后医护人员和老年人的新冠病毒奥密克戎变异株中和抗体水平
Anu Haveri,Anna Solastie,Nina Ekström et al.
Anu Haveri et al.
The emergence of SARS-CoV-2 Omicron variant (B.1.1.529) with major spike protein mutations has raised concern over potential neutralization escape and breakthrough infections among vaccinated and previously SARS-CoV-2-infected subjects. We ...
Nelli Heikkilä,Iivo Hetemäki,Silja Sormunen et al.
Nelli Heikkilä et al.
Long-term T-cell memory is dependent on the maintenance of memory T cells in the lymphoid tissues, and at the surface interfaces that provide entry routes for pathogens. However, much of the current information on human T-cell memory is bas...
Altered IgG glycosylation at COVID-19 diagnosis predicts disease severity [0.03%]
COVID-19确诊时IgG糖基化修饰的改变预测疾病严重程度
Manuel M Vicente,Inês Alves,Joana Gaifem et al.
Manuel M Vicente et al.
The nature of the immune responses associated with COVID-19 pathogenesis and disease severity, as well as the breadth of vaccine coverage and duration of immunity, is still unclear. Given the unpredictability for developing a severe/complic...
Mohd Arish,Farha Naz
Mohd Arish
The macrophages contribute to host defense against intracellular pathogens such as mycobacteria. Mycobacteria interact with macrophages altering their polarization state, which propagates establishment of infection. Thus, molecular macropha...
ChAdOx1-S adenoviral vector vaccine applied intranasally elicits superior mucosal immunity compared to the intramuscular route of vaccination [0.03%]
鼻内给药的ChAdOx1-S腺病毒载体疫苗诱导的粘膜免疫优于肌肉注射途径接种产生的效果
Maja Cokarić Brdovčak,Jelena Materljan,Marko Šustić et al.
Maja Cokarić Brdovčak et al.
COVID-19 vaccines prevent severe forms of the disease, but do not warrant complete protection against breakthrough infections. This could be due to suboptimal mucosal immunity at the site of virus entry, given that all currently approved va...