Post-Acute Sequelae Patients with Severe COVID-19 History Show a Prolonged Inflammatory, Vascular Injury Pattern [0.03%]
重型新冠病史的长期后遗症患者表现出持续性炎症和血管损伤模式
Louisa Ruhl,Isabell Pink,Evgeny Chichelnitskiy et al.
Louisa Ruhl et al.
SARS-CoV-2 infection can lead to persistent symptoms (i.e., long/post-COVID), especially in unvaccinated individuals. Little is known about the sustained impact of acute severe COVID-19 on immune signatures and long/post-COVID symptoms, oft...
Prophylactic Inhaled Pattern Recognition Receptor Agonists Reprogram Lung Epithelial Response and Prevent Type 2 Allergic Inflammation [0.03%]
经预防吸入的模式识别受体激动剂可重塑气道上皮细胞并防止2型过敏反应炎症发生
Mbaya Ntita,Celine Shuet Lin Kong,Dalia Hassan et al.
Mbaya Ntita et al.
Prophylactic inhalation of the synergistic agents ODN M362 and Pam2CSK4 ("Pam2ODN") protects mice against allergic lung disease, including allergic inflammation caused by house dust mite (HDM). By preventing sensitization, Pam2ODN reduces H...
No Correlation Between Interferon Signaling and Cytosolic Mitochondrial DNA/RNA Leakage in Cultured Skin Fibroblasts of Patients With Mitochondrial Diseases [0.03%]
线粒体病患者的培养皮肤纤维母细胞中干扰素信号与细胞质线粒体DNA / RNA泄漏无关
Manon Marchais,Alessandra Pennisi,Alexandre Pierga et al.
Manon Marchais et al.
Mitochondria have long been known to be involved in the regulation of innate immune response. We questioned whether cultured skin fibroblasts of patients suffering from mitochondrial diseases are valuable biological resources for the study ...
Bin Yang,Benjamin G Dewals
Bin Yang
Conventional or 'true' memory CD8+ T cells (TTM) arise from immunologically naive T cells that circulate in the periphery after selection in the thymus. During infection or immunization by a foreign antigen, naive T cells can receive antige...
Oleic Acid Promotes Treg Cell Differentiation via Autophagy Induction and Ameliorates DSS-Induced Colitis [0.03%]
油酸通过诱导自噬促进Treg细胞的分化并改善DSS小鼠结肠炎症状
Minghui Xia,Yang Liu,Xiujuan Zhao et al.
Minghui Xia et al.
Oleic acid (OA), a monounsaturated fatty acid (FA) prevalent in olive oil and key component of Mediterranean diet, exhibits anti-inflammatory effects in ulcerative colitis (UC), but its immunomodulatory mechanisms remain largely elusive. He...
Human Systems Immunology in the Omics Era: Challenges, Methods, and Emerging Directions [0.03%]
组学时代的人类系统免疫学：挑战、方法和新兴研究方向
Lennart Riemann,Reinhold Förster
Lennart Riemann
The human immune system is a highly complex, dynamic, and heterogeneous network shaped by genetic, environmental, and temporal influences. Advances in high-throughput omics technologies have transformed our ability to study this complexity ...
Viral Immunity in Immunoglobulin Products: Global Immunity Debt and Autoimmunity in the Postpandemic Era [0.03%]
免疫球蛋白产品中的病毒免疫力：后疫情时代的全球免疫力赤字与自身免疫反应
Hannes Lindahl,Katy Shaw-Saliba,H Benjamin Larman et al.
Hannes Lindahl et al.
Immunoglobulin (Ig) replacement therapy is commonly used to prevent infections in individuals with low IgG levels. These therapies are derived from pooled plasma donations from thousands of healthy individuals worldwide. This study examined...
Changes in Adaptive Immunity in Autoimmune Diseases and Aging: Shared Features, Key Differences, and Implications for Immune Vulnerability [0.03%]
自身免疫病和衰老适应性免疫的变化：共性特征、关键差异及其对免疫脆弱性的意义
Bojan Jevtić,Milica Lazarević,Đorđe Miljković et al.
Bojan Jevtić et al.
Immunologically vulnerable populations (IVP) are particularly at risk of infection due to dysregulated immune responses. Parallels, as well as contrasts, have been drawn between IVP with autoimmune diseases (AI DIS) and older adults, the tw...
Non-cognate CD8 Binding to MHC I Promotes Positive Selection of an MHC-E Restricted CD8 T Cell Population [0.03%]
非同源CD8结合MHC I促进MHC-E限制性CD8 T细胞的正向选择
Xiaokun Yang,Melissa A Colden,Rachel Coombs et al.
Xiaokun Yang et al.
MHC-E-restricted CD8 T cells are emerging as an attractive therapeutic mechanism due to their strong protective capacity and ability to respond to cells with defects in antigen processing; however, their thymic development remains poorly un...
Transcriptome-Proteome Analysis of Human Naive and Memory B Cell Subsets Reveals Isotype and Subclass-Specific Phenotypes [0.03%]
人naïve和记忆B细胞亚群的转录组与蛋白质组分析揭示了类别和亚类特异性表型
Jana Koers,Arie J Hoogendijk,Simon Tol et al.
Jana Koers et al.
Antibodies produced by B cells aid in the recognition and clearance of pathogens and are the cornerstone of vaccination strategies. Humans produce nine different antibody isotypes, and their effector functions differ according to the type o...