Osman Goni,Niklas Klümper,Maria Del Mar Muñiz Moreno et al.
Osman Goni et al.
Antibody-drug conjugates (ADCs) have transformed the therapeutic landscape of solid tumors; however, responses remain heterogeneous and complex to predict. In addition, a growing number of multiple ADC targets are either approved or in late...
SYK Signalling in NLRP3 Inflammasome-Mediated Response of Murine Microglia Activated by Immune Complexes Formed of Viral Proteins and Specific IgG [0.03%]
由病毒蛋白和特异性IgG形成的免疫复合物活化的小胶质细胞中SYK信号在NLRP3炎性小体介导的反应中的作用
Kristina Mašalaitė,Milda Norkienė,Aurelija Žvirblienė et al.
Kristina Mašalaitė et al.
Viral infections might trigger systemic inflammatory responses characterised by inflammasome activation and cytokine release, driven by immune complex (IC) formation, but the precise mechanism remains unknown. The NLRP3 inflammasome is a vi...
ADAR1 Controls Macrophage Scavenging and Lipid-Buffering Programs in Metabolic Tissues [0.03%]
ADAR1调控代谢组织中巨噬细胞的清除和脂质缓冲程序
Achilleas Fardellas,Emelie Barreby,Madara Brice et al.
Achilleas Fardellas et al.
Adenosine deaminase acting on RNA 1 (ADAR1) regulates mRNA fate and function through adenosine-to-inosine (A-to-I) RNA editing and RNA-binding activities. While its role in innate immunity is established, the broader regulatory functions of...
Interferon-Regulatory Factor 4 Is Required Not Only for Induction but Also for Maintenance of the Th17 Phenotype [0.03%]
干扰素调节因子4不仅对于诱导而且对于Th17表型的维持都是必需的
Janis Patten,Prema Erramsetti,Addi Josua Romero Olmedo et al.
Janis Patten et al.
We previously showed that primary differentiation of naïve T cells is dependent on IRF4. Now we show that maintenance of already differentiated conventional and pathogenic Th17 cells is also dependent on IRF4. ...
Human Blood IgA+ Memory B Cells Differ From IgG+ B Cells by Expressing Gut-Homing and Regulatory Markers [0.03%]
人血IgA+记忆B细胞与IgG+B细胞的不同之处在于表达肠道归巢和调节标志物
Louise Le Gal,Léo Boussamet,Alexandra Garcia et al.
Louise Le Gal et al.
IgA is the most produced immunoglobulin by the human body, mainly in secretions, and it exerts an important role in the activation and regulation of the immune system. Despite its importance, the phenotype of circulating IgA+ B cells is poo...
Accumulation of Siglec10+CX3CR1+ Macrophages in the Tumor Microenvironment of Glioblastomas [0.03%]
胶质母细胞瘤肿瘤微环境中的Siglec10+CX3CR1+巨噬细胞积累
Nico Andreas,Lucas Gath,Paul Mike Jordan et al.
Nico Andreas et al.
Glioblastoma (GBM) is one of the most aggressive primary brain tumors in adults. Despite various strategies, including differential single-cell gene expression analyses between GBM and healthy tissues, none of the resulting findings could b...
EXPRESSION OF CONCERN: Activation of Epstein-Barr Virus/C3d Receptor (gp140, CR2, CD21) on Human Cell Surface Triggers pp60src and Akt-GSK3 Activities Upstream and Downstream to PI 3-Kinase, Respectively [0.03%]
撤稿声明：在人类细胞表面活化Epstein-Barr病毒/C3d受体(gp140、CR2、CD21)触发pp60src和Akt-GSK3活性前者位于PI3-激酶上游，后者位于PI3-激酶下游
M. Barel, M. Balbo, M. Le Romancer and R. Frade, "Activation of Epstein-Barr Virus/C3d Receptor (gp140, CR2, CD21) on Human Cell Surface Triggers pp60src and Akt-GSK3 Activities Upstream and Downstream to PI 3-Kinase, Respectively," Europea...
Increased Constitutive Interferon-β Levels and Altered CD4 T Cell Homeostasis Induced by Expression of a Viral Glycoprotein [0.03%]
病毒糖蛋白的表达诱导组成型I干扰素-β水平升高及CD4+T细胞稳态改变
Hanspeter Pircher,Oliver S Thomas,Anne S Haefke et al.
Hanspeter Pircher et al.
Besides the strong Type I interferon (IFN-I) response induced by infections, IFN-I is also produced constitutively at lower levels. Constitutive IFN-I production is regulated by resident microbiota and is essential for induction of efficien...
Uncovering Immune Niches in Health and Disease Using Spatial Transcriptomics [0.03%]
利用空间转录组学揭示健康与疾病状态下的免疫生态位
Johan Thorsson,Yang Zhao,Eduardo J Villablanca et al.
Johan Thorsson et al.
Spatial transcriptomics allows for the investigation of complex cellular ecosystems directly in their native tissues and enables the dissection of immune niches as spatially organized and functionally diverse microenvironments across homeos...
B-Cell Differentiation of Human Hematopoietic Progenitors Is Efficiently Supported by Wharton Jelly-Derived Mesenchymal Stem Cells [0.03%]
人胚系祖细胞的B细胞分化可有效由沃顿胶衍生的间充质干细胞支持
Louison Collet,Hakim Ouled-Haddou,Hussein Ghamlouch et al.
Louison Collet et al.
Mesenchymal stem cells (MSC) represent the main stromal component of the bone marrow (BM) niche and are crucial to maintain hematopoietic tissue homeostasis. MSC exhibits extraordinary and multiple properties. In terms of expanding potentia...