High-dimensional Spatial Immune Profiling Highlights Microglia-Like Cells in Human Dorsal Root Ganglia [0.03%]
高维空间免疫谱系分析揭示了人类脊神经节中的微胶质细胞样细胞
Marius Schwabenland,Busranur Oeztuerk,Thomas Blank et al.
Marius Schwabenland et al.
The human dorsal root ganglia (DRG) are increasingly recognized as immunologically active sites within the peripheral nervous system. While single-cell transcriptomics has recently identified myeloid populations with microglia-like profiles...
Sustained Effector Functions and Memory Accumulation of αβ T Cells in Children With Congenital Heart Disease [0.03%]
儿童先天性心脏病中αβT细胞效应功能的持续存在和记忆积累
Yusuf Eshimutu Abu,Christoph Kammeyer,Tao Yang et al.
Yusuf Eshimutu Abu et al.
Congenital heart disease (CHD) is a major global health problem. Although treatment and survival have impressively improved, many patients face comorbidities such as increased susceptibility to infection that may shorten their lives. As man...
Integrating Genetics and Environment to Find Causal Mechanisms for Multiple Sclerosis [0.03%]
整合遗传和环境因素以寻找多发性硬化症的因果机制
Alicia Munoz Leon,Matthew R Lincoln
Alicia Munoz Leon
Genome-wide association studies (GWAS) have identified hundreds of risk loci for multiple sclerosis (MS), but we have limited knowledge of the mechanisms through which genetic variants mediate risk. Similarly, epidemiological studies implic...
Nur77 Is Associated With Polyfunctional Properties in Virus-Specific Human CD8+ T Cells [0.03%]
Nur77与病毒特异性人CD8+t细胞多效性特征相关性研究
Fabiola Martel,Daniel Rincón,Caroline Passaes et al.
Fabiola Martel et al.
Human CD8+ T cells undergo significant metabolic and transcriptional shifts during activation and differentiation. The orphan nuclear receptor Nur77 plays a role in modulating these processes and has been linked to T cell dysfunction. Howev...
Unfavourable H-CDR3 Loops in preB Cells Lead to Highly Expanded Plasma Cell Clones [0.03%]
预B细胞中不利的H-CDR3环导致大量浆细胞克隆扩增
Alaitz Aranburu,Erik Engström,Erik Demitz-Helin et al.
Alaitz Aranburu et al.
The immune system is essential for protection against invading pathogens. However, if it fails to distinguish between non-self (pathogens) and self, autoimmunity can result. B cells recognise pathogens using their B-cell antigen receptor (B...
Anne S Haefke,Hanna Gröber,Ioana Sandu et al.
Anne S Haefke et al.
Peripheral tolerance is indispensable for the maintenance of immune homeostasis, allowing protective immunity while limiting responses to self-antigens. CD8 T cells activated in the absence of co-stimulation and pro-inflammatory cytokines a...
Mapping of Neutrophils in Cancers: Insights From Spatial Omics Technologies [0.03%]
空间组学技术揭示肿瘤中中性粒细胞的图谱及其功能作用
Xiaohe Li,Xi He,Shan Cao et al.
Xiaohe Li et al.
Tumor neutrophils exhibit marked phenotypic plasticity and can play dual roles in tumor biology, encompassing both tumor-promoting and tumor-suppressive activities. Single-cell RNA sequencing (scRNA-seq) enables transcriptomic profiling of ...
Adapted Live SARS-CoV-2 Vaccine Elicits Rapid Mucosal Immunity, Protects From Disease, and Reduces Shedding of XBB.1.5 [0.03%]
一种改良型活SARS-CoV-2疫苗能快速激发黏膜免疫，防止疾病，并减少XBB.1.5排出量
Jana Kochmann,Tobias Britzke,Nico Joël Halwe et al.
Jana Kochmann et al.
The emergence of SARS-CoV-2 variants, like XBB.1.5, causing immune evasion and frequent breakthrough infections, emphasizes the need for vaccines that limit transmission and target newly emerging variants. Mucosal vaccines, particularly liv...
Borrelia burgdorferi sensu lato Employs Several Escape Mechanisms to Bypass the Human Defense System [0.03%]
伯氏疏螺旋体属通过多种机制逃避免疫系统的识别与杀伤
Zara Karami,Hadewych J M Ter Hofstede,Leo A B Joosten
Zara Karami
Lyme borreliosis (LB), caused by Borrelia burgdorferi sensu lato (Bbsl) through Ixodes tick bites, presents diverse clinical manifestations and may lead to persistent symptoms. This review summarizes current knowledge on the pathogen-host i...