Equine Asthma Is Characterised by Severity-Dependent Correlations Between Blood Neutrophil Cholesterol Content and NET Formation [0.03%]
血清胆固醇与哮喘严重程度及中性粒细胞胞外陷阱形成的相关性
Lia K Meiseberg,AhmedElmontaser Mergani,Julien Delarocque et al.
Lia K Meiseberg et al.
Equine asthma (EA) is the most prevalent chronic lung disease in horses. Neutrophils are the main effector cells in severe EA. Neutrophil extracellular traps (NETs) have been described as contributors to severity in human asthma and chronic...
Significance of miRNA Profile of Regulatory T Cells (Tregs) After Baricitinib Treatment in Rheumatoid Arthritis Patients [0.03%]
巴瑞克替尼治疗类风湿关节炎患者后调节性T细胞（Treg）的miRNA谱的意义
Magdalena Massalska,Anna Felis-Giemza,Patrycja Gardias et al.
Magdalena Massalska et al.
Several studies proved that microRNA (miRNA) originated from cells or body fluids can serve as disease-specific biomarkers in many diseases, including rheumatoid arthritis (RA). In this study, we investigated the effects of Janus Kinase (JA...
Antigen-Specific Tolerance: Clinical and Preclinical Approaches in Autoimmunity [0.03%]
自身免疫的临床和前期实验中的抗原特异性耐受诱导方法
Priscilla P M Faas,Stephanie D Scharmann,Novalia Pishesha
Priscilla P M Faas
Autoimmune diseases arise from a breakdown in immune tolerance. This leads to self-reactive immune responses and chronic inflammation. Induction of antigen-specific tolerance offers a targeted approach that restores immune balance without g...
Exosome miR-6990-5p from MMP14high Macrophage Promotes Fibrosis Through Th17 Cell Differentiation in Hypersensitivity Pneumonia [0.03%]
MMP14高表达巨噬细胞来源的外泌体miR-6990-5p通过促进Th17细胞分化在过敏性肺炎中促进纤维化
Dan Peng,Juan Li,Bomiao Qin et al.
Dan Peng et al.
Th17 cells contribute to pulmonary fibrosis, but the mechanisms driving their differentiation remain unclear. Using single-cell RNA sequencing (scRNA-seq) and a decision tree model, we identify IL17A as a key marker in mice exposed to Sacch...
Loss of PI3Kδ Activity Drives Autoimmune Colitis by Impairing Extrathymic Treg Differentiation [0.03%]
PI3Kδ活性丧失通过抑制外周调节性T细胞分化驱动自身免疫性结肠炎
Ee Lyn Lim,Yamin Qian,Fuminori Sugihara et al.
Ee Lyn Lim et al.
Peripherally derived regulatory T cells (pTregs) have a prominent role in maintaining intestinal immune homeostasis. In cases of phosphoinositide-3-kinase δ (PI3Kδ) inactivation, such as in patients receiving PI3Kδ inhibitor idelalisib a...
Abundant Yet Aberrant T Helper Cell Responses to Candida albicans Underlie Mucosal Candidiasis in Humans and Mice [0.03%]
人类和小鼠中丰富的白色念珠菌辅助性T细胞反应导致了粘膜念珠菌病异常现象
Camilla Basso,Corinne De Gregorio,Roberta Marzi et al.
Camilla Basso et al.
T helper cell subsets-Th1, Th2, and Th17-coordinate pathogen-specific immune responses. Candida albicans-specific T cells include protective Th17 cells alongside other Th subsets. However, the role of alternative Th subsets remains unclear,...
Imaging Mass Cytometry-Based Immune Profiling of Human Peyer's Patches in Patients with Crohn's Disease [0.03%]
基于成像质谱流式细胞术的克罗恩病患者派耶斑免疫特征分析
Adrian Huck,Yasmina Rodriguez-Sillke,Christian Bojarski et al.
Adrian Huck et al.
Lymphoid follicles in the human gut are critical immune hubs, yet their role in Crohn's disease pathogenesis remains poorly understood. Here, we apply multiplexed imaging mass cytometry to spatially profile Peyer's patches and lymphoid foll...
From Histology to High-Resolution Mapping: The Rise of Spatial Omics in Immunology [0.03%]
从组织学至高分辨率定位：免疫学中空间组学的兴起
Marco De Giovanni,Donato Inverso,Matteo Iannacone
Marco De Giovanni
The immune system is deeply shaped by its anatomical context, with spatial organization emerging as a fundamental principle of immune regulation. Recent advances in spatial omics technologies-encompassing transcriptomics, proteomics, metabo...
Low-Input Assay for Transposase-Accessible Chromatin Identifies Epigenetic Signatures of Liver Group 1 Innate Lymphoid Cells [0.03%]
低输入的转座酶可访问染色质测定法可识别肝脏组1固有淋巴细胞的表观遗传特征
Kevin Schmid,Robin P Schenk,Gabriela M Wiedemann
Kevin Schmid
Assessing chromatin accessibility in rare cell populations within tissue remains a key challenge. To address this, we present a low-input ATAC workflow optimized for liver ILCs. The protocol is validated across cell numbers, Tn5 ratios, and...
TNF Production or TNFR2 Expression Characterize Distinct States of Regulatory T Cells that Cooperate in Treg Expansion in Cancer and Chronic Inflammation [0.03%]
肿瘤坏死因子的产生或TNFR2的表达表征了调节性T细胞的不同状态，这两种状态在癌症和慢性炎症中协同促进Tregs增殖
Gloria Tucci,Ilenia Pacella,Alessandra Pinzon Grimaldos et al.
Gloria Tucci et al.
TNF is a pleiotropic cytokine with immunomodulatory functions mediated by its interaction with the receptor TNFR2, highly expressed by Tregs. However, Tregs can also produce TNF, and an autocrine TNF-TNFR2 loop has been proposed. Here, we d...