IL-10- and IL-13-Biased T Cell Responses to SARS-CoV-2 Vaccination in Diabetes [0.03%]
糖尿病患者的SARS-CoV-2疫苗接种诱导出以IL-10和IL-13偏嗜为主的T细胞反应
Emma M Jones,Caren Sourij,Martin Stradner et al.
Emma M Jones et al.
Type 1 and type 2 diabetes are associated with increased severity and mortality from respiratory virus infections. Vaccination in the general population significantly reduces the risk of severe respiratory viral infection and triggers a str...
Spatial Immunometabolism: Integrating Technologies to Decode Cellular Metabolism in Tissues [0.03%]
空间免疫代谢：整合技术以解码组织中的细胞代谢
Felix J Hartmann
Felix J Hartmann
The metabolic programs of immune cells influence their activation, differentiation, and effector functions. While much of immunometabolism has focused on cell-intrinsic regulation, it is now clear that metabolic activity is profoundly influ...
Divergent Effects of Cytomegalovirus and Rheumatoid Arthritis on Senescent CD4+ T Cells [0.03%]
巨细胞病毒和类风湿性关节炎对衰老CD4+t细胞的发散效应
Lea Williams,Ali O Saber,Silina Awad et al.
Lea Williams et al.
Chronic antigen exposure drives CD4⁺ T cell senescence, yet how autoimmunity and persistent viral infections differentially shape T cell differentiation and function remains unclear. Using cytomegalovirus (CMV) and rheumatoid arthritis (RA...
Enhanced MHC Class-II Expression in Fibroblastic Reticular Cells Associates with Maturation [0.03%]
成纤维细胞网状细胞中MHC-Ⅱ类分子表达增强与成熟相关
Janna E G Roet,Catarina Gago da Graça,Michael de Kok et al.
Janna E G Roet et al.
Autoimmunity can be initiated by autoreactive T cells that escaped central and peripheral tolerance induction. Peripheral tolerance in lymph nodes (LNs) is maintained by fibroblastic reticular cells (FRCs) via self-antigen presentation in m...
Not Just Passing Through: Bone Marrow as a Home for Diverse Resident T Cells [0.03%]
骨髓作为多样的常驻T细胞的家园
Kyra D Zens,Klaas P J M van Gisbergen
Kyra D Zens
Recent studies add to our understanding of T cell residency in the human bone marrow (BM). In the May 2025 issue of EJI, Schneider Revueltas et al. demonstrate that CD69- CD4+ and CD8+ memory T cells, presumed to be recirculating, have a di...
Differential Regulation of TCR-Induced ZFP36 and ZFP36L1 Expression by Cyclosporin A in CD8+ T Cells [0.03%]
环孢素A通过差异调节CD8+t细胞中TCR诱导的ZFP36和ZFP36L1表达发挥免疫抑制作用
Marian Jones Evans,Twm J Mitchell,Magdalena Zaucha et al.
Marian Jones Evans et al.
CD8+ T cells target infected or malignant cells via the production of pro-inflammatory cytokines and direct target cell killing. Members of the ZFP36-family of RNA-binding proteins, ZFP36 and ZFP36L1, regulate these functions in T cells via...
The Phenotypical and Functional Effect of PGE2 on Human Macrophages [0.03%]
PGE2对人单核细胞/巨噬细胞表型和功能的影响作用研究
Maren Pfirrmann,Johanna Bödder,Rowan Wuestenenk et al.
Maren Pfirrmann et al.
Prostaglandin E2 (PGE2) is one important immunosuppressive factor within the tumor microenvironment (TME). Signaling through E-prostanoid receptor type 2 (EP2) and EP4, PGE2 promotes suppressive immune cell phenotypes and impairs antitumor ...
Correction to "Nitrosonisoldipine is a selective inhibitor of inflammatory caspases and protects against pyroptosis and related septic shock" [0.03%]
关于“硝基异山梨酯是一种炎性caspase的选择性抑制剂可保护细胞免受焦亡及脓毒性休克影响”的更正
Published Erratum
European journal of immunology. 2025 Nov;55(11):e70082. DOI:10.1002/eji.70082 2025
Multifaceted Role of ILCs in Metabolic Adaptations: From Adult to Neonate [0.03%]
ILC在代谢适应中的多面角色：从成人到新生儿
Fabian Guendel,Emelyne Lécuyer
Fabian Guendel
In the almost two decades since their discovery, innate lymphoid cells (ILCs) have received considerable attention for their roles in immune defense and tissue repair. However, a growing body of evidence now highlights a broader functional ...
Epigenetically Controlled ZEB2 Expression Promotes the Cytotoxic Potential of CMV-Specific CD8+ T Cells [0.03%]
表观遗传调控的ZEB2表达促进CMV特异性CD8+T细胞的胞毒性潜力
Varun Sasidharan Nair,Zheng Yu,Hosein Ahmadi et al.
Varun Sasidharan Nair et al.
Zinc finger E-box binding protein 2 (ZEB2) is a key factor in the differentiation of naïve CD8+ T cells into effector and memory T cells. However, the precise regulatory role of ZEB2 in cytotoxic CD8+ T cells remains unknown. Our recent DN...