Mastering Immunity: Antibody Feedback as a Driver of Germinal Center Fate and Vaccine Responses [0.03%]
掌握免疫力：抗体反馈作为生发中心命运和疫苗反应的驱动因素
Shuang Liu,Yang Zhang,Kai-Michael Toellner
Shuang Liu
Antibody feedback in germinal center (GC) responses plays a key role in shaping the affinity, specificity, and longevity of humoral immunity. Beyond neutralizing pathogens, antibodies influence B cell selection by modulating antigen availab...
Decoding the Cryptic Proteome Between Antigens and Novel Functional Proteins [0.03%]
解读抗原与新型功能蛋白之间的隐秘蛋白质组
Emma G Bawden,Sebastian Amigorena,Yago A Arribas
Emma G Bawden
The widespread translation of cryptic proteins derived from the non-coding genome expands the complexity of the human proteome. A vast majority of cryptic proteins are expressed at low levels, rapidly degraded and efficiently presented on c...
Hyperinflammation by Human Macrophages Induced by SARS-CoV-2 Anti-Spike IgG Is Dependent on Glucose and Fatty Acid Metabolism [0.03%]
由SARS-CoV-2刺突抗体IgG诱导的人巨噬细胞高炎症依赖葡萄糖和脂肪酸代谢
Chiara E Geyer,Luís Almeida,Lynn Mes et al.
Chiara E Geyer et al.
Severe COVID-19 is an immunological disorder characterized by excessive immune activation following infection with SARS-CoV-2, which typically occurs around the time of seroconversion. Anti-spike IgG of critically ill COVID-19 patients indu...
Diurnally-Regulated Corticosterone and Melatonin Inversely Control Endotoxin-Induced Acute Immune Responses [0.03%]
促肾上腺皮质激素和褪黑素的昼夜调节相反调控内毒素诱导的急性免疫反应
Montaser Haddad,Sebastien Trzebanski,Ramon Bossardi Ramos et al.
Montaser Haddad et al.
The timing of endotoxin administration in mice matters and is associated with diurnal variation in survival; however, underlying mechanisms remain poorly understood. Here, we report that afternoon LPS challenges in mice induce a robust infl...
Functional Antigen-Specific CD8 TSCM Responses Are Associated with Repeated Clearance of Hepatitis C Virus Infection [0.03%]
功能性抗原特异性CD8 TSCM反应与反复清除丙型肝炎病毒有关
Yanran Zhao,Elizabeth Keoshkerian,Hui Li et al.
Yanran Zhao et al.
Natural clearance of hepatitis C virus (HCV) infection occurs in about 25% of primary infections, but offers only partial protective immunity against re-infections. This study hypothesised that long-lived polyfunctional HCV-specific CD8+ me...
Ultrasensitive Test Systems Are Required to Quantify Interferon Alpha Protein in Serum Samples [0.03%]
超灵敏检测系统用于测定血清样本中的干扰素α蛋白含量
Liis Haljasmägi,Sandra Meisalu,Vincent Bondet et al.
Liis Haljasmägi et al.
Selecting a sensitive test system is crucial to measure IFNα in serum samples. Simoa digital ELISA stands out for its high sensitivity and strong correlation with transcript-based IFN-induced gene (ISG) scores. In SLE, the ISG score is exp...
Selection and Characterisation of Minor Histocompatibility Antigen-Specific Regulatory T Cells in Fully HLA-Matched Setting for GVHD Therapy [0.03%]
完全HLA配型背景下供者特异性调节性T细胞的筛选及鉴定在GVHD治疗中的应用研究
Pacini Carolina Paulino,Rita I Azevedo,Luís Ramalhete et al.
Pacini Carolina Paulino et al.
Graft-versus-host disease is mediated by donor-derived T cells reactive against the recipient's broadly expressed minor histocompatibility antigens (mHA). Regulatory T cells (Treg) have been explored as a therapeutic approach for chronic GV...
Mass Cytometry-Based Approach for the Investigation of Stimulator of Interferon Genes Pathway [0.03%]
基于质谱细胞分析的干扰素基因刺激通路研究方法
Anne Reversat,Paul T Kennedy,Anni Georghiou et al.
Anne Reversat et al.
The stimulator of interferon genes (STING) pathway plays a pivotal role in innate immunity, acting as a key sensor of cytosolic DNA to initiate type-I Interferon (IFN) and pro-inflammatory cytokine production. This pathway is essential for ...
Domien Vanneste,Thomas Marichal
Domien Vanneste
Tissue-resident and recruited macrophages are integral to organ development, homeostasis, immunity, and disease pathogenesis. Their remarkable diversity arises from distinct developmental origins, differentiation trajectories, and microenvi...
The Antigen Presenting Capabilities of Group 3 Innate Lymphoid Cells: Insights Into Immunogenic or Tolerogenic Outcomes for T Cells [0.03%]
组3固有淋巴样细胞的抗原提呈能力：T细胞免疫原性或耐受性的新见解
Alessia Calabrò,Sayuri Yamazaki,Guido Ferlazzo et al.
Alessia Calabrò et al.
Group 3 innate lymphoid cells (ILC3s) are tissue-resident lymphocytes distributed across both lymphoid and non-lymphoid tissues, capable of mounting rapid immune responses. They are defined by expression of the transcription factor RORγt a...