A Cell-Intrinsic Role for RANK in Regulatory T Cells of the Human Thymus [0.03%]
人胸腺调节性T细胞中RANK的固有作用
Zoe-Isabella Junginger,Ramona Adameck,Alexandre A S F Raposo et al.
Zoe-Isabella Junginger et al.
We identified RANK (TNFRSF11a) expression in human thymic FOXP3+ Tregs, revealing a previously unknown role for the RANK-RANKL axis in human tTreg development. We show that IL-2 and IL-15 can drive RANK expression in CD4+ tTregs, which in t...
Microbial-Immune Interplay in CNS Autoimmune Diseases: Lessons from Animal Models and Clinical Studies [0.03%]
中枢神经系统自身免疫病中微生物和免疫的相互作用：来自动物模型和临床研究的经验教训
Matteo Ceccon,Francesca Ronchi
Matteo Ceccon
The gut microbiota plays a key role in shaping and educating host immunity, and it may also influence the central nervous system (CNS). Changes in the composition and function of commensal microbes can trigger inflammation and abnormal immu...
Proteomic Analysis of Regulated Dendritic Cell Endosomes Reveals Dynamic Adaptation to Antigen Uptake and Cross-Presentation [0.03%]
调节树突状细胞内体的蛋白质组分析揭示了对抗原摄取和交叉呈递的动态适应性
Alice Senni,Louise Grumbach,Sara Ceccacci et al.
Alice Senni et al.
MHC class I (MHC-I) cross-presentation involves final proteolytic peptide processing by the endosomal insulin-regulated aminopeptidase (IRAP). Reasoning that analysis of the IRAP-proximal proteome may inform about dynamic remodeling of a ke...
Stabilization of Human CD8+ Treg in Inflammatory Environments Through FOXP3 Expression [0.03%]
炎性环境下通过FOXP3表达稳定人CD8+treg细胞
Séverine Bézie,Jenny Greig,Sonia Salle et al.
Séverine Bézie et al.
Cell therapy using regulatory T cells (Tregs) holds therapeutic promise in immune-mediated diseases, but their stability and persistence after transfer into inflammatory environments remain major challenges. CD8+ Tregs, in particular, expre...
Developmental Impact of Maternal Immune Activation on the Fetal Immune System and Lung [0.03%]
母体免疫激活对胎儿免疫系统和肺的影响
Walaa Jradi,Kira Duhm,Clarissa Prazeres da Costa
Walaa Jradi
Maternal immune activation (MIA) refers to an immune response triggered in a pregnant mother by infections, inflammation, or other immune challenges that can impact offspring health. We propose aligning MIA within the framework of the devel...
Environmental Signals That Drive Early Life Innate Lymphoid Cell Development [0.03%]
调控早期生命先天淋巴细胞发育的环境信号
Emily N Kulp,Colleen M Lau
Emily N Kulp
Our expanding knowledge of innate lymphoid cells (ILCs) over the last two decades has demonstrated the pivotal role these cells play in homeostasis and host defense. Recent work suggests that the observed heterogeneity within different ILC ...
IgD-Expressing Mature B Cells Exhibit Enhanced Sensitivity to Glucocorticoid-Induced Cell Death [0.03%]
表达IgD的成熟B细胞对糖皮质激素诱导的细胞死亡更为敏感
Kais Almohammad,Marc Young,Sabine Vettorazzi et al.
Kais Almohammad et al.
Glucocorticoids (GCs) regulate diverse physiological processes, comprising metabolism, immune responses, stress adaptation, and inflammation. Synthetic GCs are widely used for their powerful anti-inflammatory and immunosuppressive effects, ...
Restoring Immunological Tolerance via Dendritic Cells in Rheumatoid Arthritis [0.03%]
树突状细胞在类风湿性关节炎免疫耐受重建中的作用
Hannah Costello,Andrea Woodcock,Mary Canavan
Hannah Costello
Rheumatoid arthritis (RA) represents a major global public health challenge, with approximately 1% of the world's population suffering from this disease. In the absence of a cure, patients require ongoing and very often lifelong treatment. ...
Matteo Villa
Matteo Villa
Autoimmunity causes damage to organs targeted by the effector function of the immune response. The dynamics of autoimmunity in human peripheral tissues are not well understood due to the limited access to tissue samples. As cellular metabol...
Downregulation of CD19 Expression Associates With Mantle Cell Lymphoma Relapse Following CAR-T Cell Therapy [0.03%]
CAR-T细胞治疗后套细胞淋巴瘤复发与CD19表达下调相关
Benedetta Peruzzi,Alessio Mazzoni,Ilaria Cutini et al.
Benedetta Peruzzi et al.
We report the case of a stage 4 mantle cell lymphoma patient, resistant to conventional first- and second-line therapies, treated with CAR-T cells. The therapy was initially efficacious, with an appreciable CAR-T cells expansion in vivo. Ho...